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- Publisher
- Wiley
- Copyright
- Copyright © 2006 Wiley Subscription Services
- ISSN
- 0023-852X
- eISSN
- 1531-4995
- DOI
- 10.1097/01.mlg.0000224527.41288.c4
- pmid
- 16826039
- Publisher site
- See Article on Publisher Site
Abstract
Objectives/Hypothesis: Chronic otitis media is a significant clinical problem. Understanding the mechanisms of chronic otitis media is critical for its control. However, little is known of these processes as a result of lack of animal models of spontaneous otitis media. The C3H/HeJ mouse has a single amino acid substitution in its toll‐like receptor 4 (TLR4), making it insensitive to endotoxin. As a result, these mice cannot clear Gram‐negative bacteria. The chronically inflamed middle ear in this animal provides us the opportunity to study spontaneous chronic otitis media.
Journal
The Laryngoscope – Wiley
Published: Jan 1, 2006
Keywords: ; ; ; ;