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Mad2 prevents aneuploidy and premature proteolysis of cyclin B and securin during meiosis I in mouse oocytes

Mad2 prevents aneuploidy and premature proteolysis of cyclin B and securin during meiosis I in... Downloaded from genesdev.cshlp.org on December 10, 2021 - Published by Cold Spring Harbor Laboratory Press RESEARCH COMMUNICATION teolysis of securin and cyclin B, thereby inducing ana- Mad2 prevents aneuploidy and phase and cytokinesis (Peters 2002). As in mitosis, se- curin and cyclin B destruction are required for homolog premature proteolysis of cyclin disjunction and exit from meiosis I in mouse oocytes B and securin during meiosis I (Herbert et al. 2003). In mammalian somatic cells, the Mad2-dependent in mouse oocytes spindle checkpoint is required for mitotic arrest in the 1,2,5 2,4 presence of spindle poisons (Li and Benezra 1996) and to Hayden A. Homer, Alex McDougall, delay anaphase until proper chromosome alignment in 2 1 Mark Levasseur, Katie Yallop, the absence of spindle damage (Gorbsky et al. 1998). Dur- 1,3 1,3,6 Alison P. Murdoch, and Mary Herbert ing meiosis I in budding yeast, Mad2 is also required to arrest cells following spindle disruption and to avert Newcastle Fertility Centre at Life, Centre for Life, Newcastle nondisjunction in unperturbed cells (Shonn et al. 2000, upon Tyne NE1 4EP, United Kingdom; School of Cell and 2003). In mouse oocytes, a dominant-negative variant of Molecular Biosciences and School of Surgical and human http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Genes & Development Unpaywall

Mad2 prevents aneuploidy and premature proteolysis of cyclin B and securin during meiosis I in mouse oocytes

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Unpaywall
ISSN
0890-9369
DOI
10.1101/gad.328105
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Abstract

Downloaded from genesdev.cshlp.org on December 10, 2021 - Published by Cold Spring Harbor Laboratory Press RESEARCH COMMUNICATION teolysis of securin and cyclin B, thereby inducing ana- Mad2 prevents aneuploidy and phase and cytokinesis (Peters 2002). As in mitosis, se- curin and cyclin B destruction are required for homolog premature proteolysis of cyclin disjunction and exit from meiosis I in mouse oocytes B and securin during meiosis I (Herbert et al. 2003). In mammalian somatic cells, the Mad2-dependent in mouse oocytes spindle checkpoint is required for mitotic arrest in the 1,2,5 2,4 presence of spindle poisons (Li and Benezra 1996) and to Hayden A. Homer, Alex McDougall, delay anaphase until proper chromosome alignment in 2 1 Mark Levasseur, Katie Yallop, the absence of spindle damage (Gorbsky et al. 1998). Dur- 1,3 1,3,6 Alison P. Murdoch, and Mary Herbert ing meiosis I in budding yeast, Mad2 is also required to arrest cells following spindle disruption and to avert Newcastle Fertility Centre at Life, Centre for Life, Newcastle nondisjunction in unperturbed cells (Shonn et al. 2000, upon Tyne NE1 4EP, United Kingdom; School of Cell and 2003). In mouse oocytes, a dominant-negative variant of Molecular Biosciences and School of Surgical and human

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Genes & Development – Unpaywall

Published: Jan 15, 2005

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