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Potential drug interactions with cyclosporine

Potential drug interactions with cyclosporine From the Minnesota Ciinicai Study Center, Fridley, Minnesota Correspondence H. Irving Katz, MD, Minnesota Clinical Study Center, 7205 University Avenue N.E., Fridiey, MN 55432-3134 The potential for drug interactiotis exists wlietiever tnore than one drug or one drug and another therapeutic agent are giveti coticurretitly to patietits;^""* however, the potential consequences of such drug interactions tnay be minitnized or averted if prescribers and patients recognize the underlying phartnacologic priticiples involved.'"'' Cyclosporitie is ati itnportant imtnutiosuppressive drug that is used to prevent orgati transplantation rejectioti.*'^ More recetitly, cyclosporine has been used to treat diseases that may have imtnune dysfunction as a part of their underlying tnechanistn, including various fortns of psoriasis.'""" This article briefly describes the pharmacologic principles involved iti selected exatnples of potentially clinically sigtiificant drug interactions that may occur with cyclosporine. Pharmacologic basis of drug interactions Drug ititeractiotis occur when two or more medicatiotis alter the tnanner in which otie or tnore of these agetits are tiortnally dealt with or perform in a patietit. Drug interactions may be divided into two types, natnely, pharmacokinetic and pharmacodynamic (Table i).^'''"^' Therefore, the type, scope, and potential effects of drug interactions with cyclosporine are intimately linked to an understanding of http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png International Journal of Dermatology Wiley

Potential drug interactions with cyclosporine

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References (78)

Publisher
Wiley
Copyright
Copyright © 1997 Wiley Subscription Services, Inc., A Wiley Company
ISSN
0011-9059
eISSN
1365-4632
DOI
10.1046/j.1365-4362.36.s1.5.x
Publisher site
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Abstract

From the Minnesota Ciinicai Study Center, Fridley, Minnesota Correspondence H. Irving Katz, MD, Minnesota Clinical Study Center, 7205 University Avenue N.E., Fridiey, MN 55432-3134 The potential for drug interactiotis exists wlietiever tnore than one drug or one drug and another therapeutic agent are giveti coticurretitly to patietits;^""* however, the potential consequences of such drug interactions tnay be minitnized or averted if prescribers and patients recognize the underlying phartnacologic priticiples involved.'"'' Cyclosporitie is ati itnportant imtnutiosuppressive drug that is used to prevent orgati transplantation rejectioti.*'^ More recetitly, cyclosporine has been used to treat diseases that may have imtnune dysfunction as a part of their underlying tnechanistn, including various fortns of psoriasis.'""" This article briefly describes the pharmacologic principles involved iti selected exatnples of potentially clinically sigtiificant drug interactions that may occur with cyclosporine. Pharmacologic basis of drug interactions Drug ititeractiotis occur when two or more medicatiotis alter the tnanner in which otie or tnore of these agetits are tiortnally dealt with or perform in a patietit. Drug interactions may be divided into two types, natnely, pharmacokinetic and pharmacodynamic (Table i).^'''"^' Therefore, the type, scope, and potential effects of drug interactions with cyclosporine are intimately linked to an understanding of

Journal

International Journal of Dermatology – Wiley

Published: Dec 1, 1997

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