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Embryonic expression of a haematopoietic growth factor encoded by the SI locus and the ligand for c-kit

Embryonic expression of a haematopoietic growth factor encoded by the SI locus and the ligand for... MICE carrying mutations at the W (Dominant white spotting) and SI (Steel) loci develop abnormalities in three independent systems: neural crest-derived melanocytes, primordial germ cells and haematopoietic stem cells. Consequently, homozygotes of viable mutant alleles have white coats and are sterile and severely anaemic. Tissue recombination studies predict that the W gene is expressed cell autonomously, whereas the product of the SI locus affects the microenvironment in which the stem cells migrate, proliferate and differentiate1–6. The W locus encodes the proto-oncogene c-kit, a member of the tyrosine kinase receptor family7,8.The haematopoietic growth factor SCF (stem cell factor) has been identified as the product of the SI locus and a ligand for c-kit9–11. Here, we report that SCF is expressed during embryogenesis in cells associated with both the migratory pathways and homing sites of melanoblasts, germ cells and haematopoietic stem cells. Both SCF and c-kit are also expressed in a variety of other tissues, including the brain and spinal cord, suggesting that the receptor–ligand system has additional roles in embryogenesis. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Nature Springer Journals

Embryonic expression of a haematopoietic growth factor encoded by the SI locus and the ligand for c-kit

Matsui, Yasuhisa; Zsebo, Kristina M.; Hogan, Brigid L. M.
Nature , Volume 347 (6294) – Oct 18, 1990
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References (17)

Publisher
Springer Journals
Copyright
Copyright © 1990 by Nature Publishing Group
Subject
Science, Humanities and Social Sciences, multidisciplinary; Science, Humanities and Social Sciences, multidisciplinary; Science, multidisciplinary
ISSN
0028-0836
eISSN
1476-4687
DOI
10.1038/347667a0
Publisher site
See Article on Publisher Site

Abstract

MICE carrying mutations at the W (Dominant white spotting) and SI (Steel) loci develop abnormalities in three independent systems: neural crest-derived melanocytes, primordial germ cells and haematopoietic stem cells. Consequently, homozygotes of viable mutant alleles have white coats and are sterile and severely anaemic. Tissue recombination studies predict that the W gene is expressed cell autonomously, whereas the product of the SI locus affects the microenvironment in which the stem cells migrate, proliferate and differentiate1–6. The W locus encodes the proto-oncogene c-kit, a member of the tyrosine kinase receptor family7,8.The haematopoietic growth factor SCF (stem cell factor) has been identified as the product of the SI locus and a ligand for c-kit9–11. Here, we report that SCF is expressed during embryogenesis in cells associated with both the migratory pathways and homing sites of melanoblasts, germ cells and haematopoietic stem cells. Both SCF and c-kit are also expressed in a variety of other tissues, including the brain and spinal cord, suggesting that the receptor–ligand system has additional roles in embryogenesis.

Journal

Nature – Springer Journals

Published: Oct 18, 1990

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