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Alfred P. Sloan prize. Viruses, genes, and cancer. I. The discovery of cellular oncogenes and their role in neoplasia

Alfred P. Sloan prize. Viruses, genes, and cancer. I. The discovery of cellular oncogenes and... HAROLD E. VARMUS what is now known about the molecular basis of cancer, 1 have been struck by Einstein’s remark: “the eternal mystery of the world is its comprehensibility.”’ Cancer is an extraordinarily diverse disease; it arises in response to a multitude of environmental insults and inherited biases, and it is a disorder of that most complex attribute of living things-cell growth. Nevertheless, today we are able to talk, sometimes sensibly, about the molecular events that produce a cancer, because good fortune and novel technologies have delivered into our hands those relatively few genes-now called oncogenes-that provide a vocabulary for contemporary discourse about the origins of cancer. The oncogene story began inauspiciously 75 years ago when a New York State poultry farmer noted a tumor in a barred Plymourh Rock hen and brought the sick bird to Peyton Rous at the Rockefeller Institute. After multiple transplantations of the tumor, Rous found that he could induce the same kind of tumor. a sarcoma, by means of a cell-free filtrate.Ia In this way, Rous sarcoma virus (RSV), the most instructive of retroviruses, was discovered prematurely, when the tenets and techniques of experimental virology were insufficiently developed to exploit its potential. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Cancer Wiley

Alfred P. Sloan prize. Viruses, genes, and cancer. I. The discovery of cellular oncogenes and their role in neoplasia

Varmus, Harold E.
Cancer , Volume 55 (10) – Mar 15, 1986
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References (62)

Publisher
Wiley
Copyright
"Copyright © 1985 Wiley Subscription Services, Inc., A Wiley Company"
ISSN
0008-543X
eISSN
1097-0142
DOI
10.1002/1097-0142(19850515)55:10<2324::AID-CNCR2820551004>3.0.CO;2-A
Publisher site
See Article on Publisher Site

Abstract

HAROLD E. VARMUS what is now known about the molecular basis of cancer, 1 have been struck by Einstein’s remark: “the eternal mystery of the world is its comprehensibility.”’ Cancer is an extraordinarily diverse disease; it arises in response to a multitude of environmental insults and inherited biases, and it is a disorder of that most complex attribute of living things-cell growth. Nevertheless, today we are able to talk, sometimes sensibly, about the molecular events that produce a cancer, because good fortune and novel technologies have delivered into our hands those relatively few genes-now called oncogenes-that provide a vocabulary for contemporary discourse about the origins of cancer. The oncogene story began inauspiciously 75 years ago when a New York State poultry farmer noted a tumor in a barred Plymourh Rock hen and brought the sick bird to Peyton Rous at the Rockefeller Institute. After multiple transplantations of the tumor, Rous found that he could induce the same kind of tumor. a sarcoma, by means of a cell-free filtrate.Ia In this way, Rous sarcoma virus (RSV), the most instructive of retroviruses, was discovered prematurely, when the tenets and techniques of experimental virology were insufficiently developed to exploit its potential.

Journal

Cancer – Wiley

Published: Mar 15, 1986

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