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Life at extremely low pH

Life at extremely low pH SCIENTIFIC CORRESPONDENCE Life at extremely mutY 'directs' mutation? low pH SIR - The ability of cells to undergo were slow-growing suppressors similar to spontaneous mutation while in the resting those observed in the mutY+ strain, show­ state was demonstrated by Ryan et al. ing that they can, as predicted, be caused SIR - Only four organisms, oddly enough with Escherichia coli more than 30 years by 8-oxo-G. If the suppressor mutants that all eukaryotes, have so far been reported ago, but received little attention until the arise in the tyrA14 ochre strain under star­ to grow at pH values around zero: report by Cairns and collaborators that vation conditions are at the anticodon of a the thermoacidophilic coccoid rhodo­ the mutations that arose were 'directed', transfer RNA locus, then the 8-oxo-G can phyte Cyanidium caldarium ; the fun~i that is, they specifically overcame what­ be formed on the transcribed strand. Mis­ Acontium cylatium; Cephalosporium sp. ; ever starvation was imposed to maintain coding during transcription would result in and Trichosporon cerebriae • We have now them in a non-growing state. a transient Tyr+ phenotype, which could identified two related species of archaea Apparently, 'directed' mutation to pro­ allow a http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Nature Springer Journals

Life at extremely low pH

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References (6)

Publisher
Springer Journals
Copyright
Copyright © 1995 by Nature Publishing Group
Subject
Science, Humanities and Social Sciences, multidisciplinary; Science, Humanities and Social Sciences, multidisciplinary; Science, multidisciplinary
ISSN
0028-0836
eISSN
1476-4687
DOI
10.1038/375741b0
Publisher site
See Article on Publisher Site

Abstract

SCIENTIFIC CORRESPONDENCE Life at extremely mutY 'directs' mutation? low pH SIR - The ability of cells to undergo were slow-growing suppressors similar to spontaneous mutation while in the resting those observed in the mutY+ strain, show­ state was demonstrated by Ryan et al. ing that they can, as predicted, be caused SIR - Only four organisms, oddly enough with Escherichia coli more than 30 years by 8-oxo-G. If the suppressor mutants that all eukaryotes, have so far been reported ago, but received little attention until the arise in the tyrA14 ochre strain under star­ to grow at pH values around zero: report by Cairns and collaborators that vation conditions are at the anticodon of a the thermoacidophilic coccoid rhodo­ the mutations that arose were 'directed', transfer RNA locus, then the 8-oxo-G can phyte Cyanidium caldarium ; the fun~i that is, they specifically overcame what­ be formed on the transcribed strand. Mis­ Acontium cylatium; Cephalosporium sp. ; ever starvation was imposed to maintain coding during transcription would result in and Trichosporon cerebriae • We have now them in a non-growing state. a transient Tyr+ phenotype, which could identified two related species of archaea Apparently, 'directed' mutation to pro­ allow a

Journal

Nature – Springer Journals

Published: Jun 29, 1995

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