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- Publisher
- Springer Journals
- Copyright
- Copyright © 2014 by Nature Publishing Group, a division of Macmillan Publishers Limited. All Rights Reserved.
- Subject
- Medicine & Public Health; Medicine/Public Health, general; Rheumatology
- ISSN
- 1759-4790
- eISSN
- 1759-4804
- DOI
- 10.1038/nrrheum.2014.33
- Publisher site
- See Article on Publisher Site
Abstract
TNF ligand superfamily member 13B (also known as B cell-activating factor of the TNF family [BAFF]) and TNF ligand superfamily member 13 (also known as a proliferation-inducing ligand [APRIL]) are important modulators of autoimmunity Data indicate that alteration of the BAFF/APRIL system affects the capacity of the innate immune system to regulate B-cell activation BAFF and type I interferons function together in systemic lupus erythematosus (SLE) pathogenesis in both a Toll-like receptor-dependent and independent manner Defining the clinical manifestations of disease related to alterations of the BAFF/APRIL system might help to stratify patients with SLE into subgroups that are more likely to benefit from anti-BAFF treatment Differences in the molecular forms of BAFF might affect the efficacy of BAFF-specific therapies
Journal
Nature Reviews Rheumatology – Springer Journals
Published: Mar 11, 2014