Access the full text.
Sign up today, get DeepDyve free for 14 days.
Matthew Kennedy, J. Nemec, D. Clapham (1996)
Localization and Interaction of Epitope-tagged GIRK1 and CIR Inward Rectifier K+ Channel SubunitsNeuropharmacology, 35
K. Wickman, J. Iñiguez-Lluhí, P. Davenport, R. Taussig, G. Krapivinsky, M. Linder, A. Gilman, D. Clapham (1994)
Recombinant G-protein βγ-subunits activate the muscarinic-gated atrial potassium channelNature, 368
T. Licht, Lilia Tsirulnikov, H. Reuveni, T. Yarnitzky, S. Ben‐Sasson (2003)
Induction of pro-angiogenic signaling by a synthetic peptide derived from the second intracellular loop of S1P3 (EDG3).Blood, 102 6
V. Brinkmann, Michael Davis, C. Heise, R. Albert, S. Cottens, R. Hof, C. Bruns, E. Prieschl, T. Baumruker, P. Hiestand, C. Foster, M. Zollinger, K. Lynch (2002)
The Immune Modulator FTY720 Targets Sphingosine 1-Phosphate Receptors*The Journal of Biological Chemistry, 277
H. Chuang, Mei Yu, Y. Jan, L. Jan (1998)
Evidence that the nucleotide exchange and hydrolysis cycle of G proteins causes acute desensitization of G-protein gated inward rectifier K+ channels.Proceedings of the National Academy of Sciences of the United States of America, 95 20
K. Budde, Robert Schmouder, B. Nashan, R. Brunkhorst, Peter Lücker, Thomas Mayer, L. Brookman, J. Nedelman, A. Skerjanec, T. Böhler, H. Neumayer (2003)
Pharmacodynamics of Single Doses of the Novel Immunosuppressant FTY720 in Stable Renal Transplant PatientsAmerican Journal of Transplantation, 3
V. Brinkmann, K. Lynch (2002)
FTY720: targeting G-protein-coupled receptors for sphingosine 1-phosphate in transplantation and autoimmunity.Current opinion in immunology, 14 5
K. Budde, R. Schmouder, R. Brunkhorst, B. Nashan, P. Lücker, Thomas Mayer, S. Choudhury, A. Skerjanec, G. Kraus, H. Neumayer (2002)
First human trial of FTY720, a novel immunomodulator, in stable renal transplant patients.Journal of the American Society of Nephrology : JASN, 13 4
K. Chiba, Y. Yanagawa, Y. Masubuchi, H. Kataoka, T. Kawaguchi, M. Ohtsuki, Y. Hoshino (1998)
FTY720, a novel immunosuppressant, induces sequestration of circulating mature lymphocytes by acceleration of lymphocyte homing in rats. I. FTY720 selectively decreases the number of circulating mature lymphocytes by acceleration of lymphocyte homing.Journal of immunology, 160 10
Y. Yanagawa, Y. Masubuchi, K. Chiba (1998)
FTY720, a novel immunosuppressant, induces sequestration of circulating mature lymphocytes by acceleration of lymphocyte homing in rats, III. Increase in frequency of CD62L‐positive T cells in Peyer’s patches by FTY720‐induced lymphocyte homingImmunology, 95
Matthew Kennedy, J. Nemec, S. Corey, K. Wickman, D. Clapham (1999)
GIRK4 Confers Appropriate Processing and Cell Surface Localization to G-protein-gated Potassium Channels*The Journal of Biological Chemistry, 274
Dario DiFrancesco (1995)
The onset and autonomic regulation of cardiac pacemaker activity: relevance of the f current.Cardiovascular research, 29 4
M. Yamada (2002)
The role of muscarinic K(+) channels in the negative chronotropic effect of a muscarinic agonist.The Journal of pharmacology and experimental therapeutics, 300 2
C. Koppen, D. Heringdorf, K. Laser, Chunyi Zhang, K. Jakobs, M. Bünemann, L. Pott (1996)
Activation of a High Affinity G Protein-coupled Plasma Membrane Receptor by Sphingosine-1-phosphate (*)The Journal of Biological Chemistry, 271
A. Yatani, L. Birnbaumer, A. Brown (1990)
Direct coupling of the somatostatin receptor to potassium channels by a G protein.Metabolism: clinical and experimental, 39 9 Suppl 2
T. Sanchez, T. Hla (2004)
Structural and functional characteristics of S1P receptorsJournal of Cellular Biochemistry, 92
K. Wickman, D. Clapham (1995)
Ion channel regulation by G proteins.Physiological reviews, 75 4
Guo (1999)
Effects of sphingosine 1-phosphate on pacemaker activity in rabbit sino-atrial node cells.Pflugers Arch, 438
H. Himmel, D. Heringdorf, E. Graf, D. Dobrev, A. Kortner, Stephan Schüler, K. Jakobs, U. Ravens (2000)
Evidence for Edg-3 receptor-mediated activation of I(K.ACh) by sphingosine-1-phosphate in human atrial cardiomyocytes.Molecular pharmacology, 58 2
D. DiFrancesco (1995)
Cardiac pacemaker: 15 years of "new" interpretation.Acta cardiologica, 50 6
H. Tedesco-Silva, G. Mourad, B. Kahan, J. Boira, W. Weimar, S. Mulgaonkar, B. Nashan, S. Madsen, B. Charpentier, P. Pellet, Y. Vanrenterghem (2005)
FTY720, A Novel Immunomodulator: Efficacy and Safety Results from the First Phase 2A Study in de novo Renal TransplantationTransplantation, 79
I. Bettahi, Cheryl Marker, M. Román, K. Wickman (2002)
Contribution of the Kir3.1 Subunit to the Muscarinic-gated Atrial Potassium Channel IKACh *The Journal of Biological Chemistry, 277
P. Kovoor, Kevin Wickman, C. Maguire, William Pu, J. Gehrmann, Charles Berul, David Clapham (2001)
Evaluation of the role of I(KACh) in atrial fibrillation using a mouse knockout model.Journal of the American College of Cardiology, 37 8
S. Corey, G. Krapivinsky, L. Krapivinsky, D. Clapham (1998)
Number and Stoichiometry of Subunits in the Native Atrial G-protein-gated K+ Channel, IKACh *The Journal of Biological Chemistry, 273
K. Wickman, J. Nemec, S. Gendler, D. Clapham (1998)
Abnormal Heart Rate Regulation in GIRK4 Knockout MiceNeuron, 20
M. Forrest, S-Y Sun, R. Hajdu, J. Bergstrom, Deborah Card, G. Doherty, J. Hale, C. Keohane, C. Meyers, J. Milligan, S. Mills, N. Nomura, H. Rosen, M. Rosenbach, G. Shei, I. Singer, M. Tian, S. West, V. White, J.-E. Xie, R. Proia, S. Mandala (2004)
Immune Cell Regulation and Cardiovascular Effects of Sphingosine 1-Phosphate Receptor Agonists in Rodents Are Mediated via Distinct Receptor SubtypesJournal of Pharmacology and Experimental Therapeutics, 309
S. Mandala, R. Hajdu, J. Bergstrom, E. Quackenbush, Jenny Xie, J. Milligan, R. Thornton, G. Shei, D. Card, C. Keohane, M. Rosenbach, J. Hale, C. Lynch, K. Rupprecht, W. Parsons, H. Rosen (2002)
Alteration of Lymphocyte Trafficking by Sphingosine-1-Phosphate Receptor AgonistsScience, 296
V. Brinkmann, J. Cyster, T. Hla (2004)
FTY720: Sphingosine 1‐Phosphate Receptor‐1 in the Control of Lymphocyte Egress and Endothelial Barrier FunctionAmerican Journal of Transplantation, 4
M. Sanna, Jiayu Liao, E. Jo, C. Alfonso, M. Ahn, M. Peterson, B. Webb, S. Lefebvre, J. Chun, N. Gray, H. Rosen (2004)
Sphingosine 1-Phosphate (S1P) Receptor Subtypes S1P1 and S1P3, Respectively, Regulate Lymphocyte Recirculation and Heart Rate*Journal of Biological Chemistry, 279
U. Kunzendorf, E. Ziegler, D. Kabelitz (2004)
FTY720--the first compound of a new promising class of immunosuppressive drugs.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 19 7
J. Guo, K. Macdonell, W. Giles (1999)
Effects of sphingosine 1-phosphate on pacemaker activity in rabbit sino-atrial node cellsPflügers Archiv, 438
G. Krapivinsky, E. Gordon, K. Wickman, B. Velimirovic, L. Krapivinsky, D. Clapham (1995)
The G-protein-gated atrial K+ channel IKAch is a heteromultimer of two inwardly rectifying K+-channel proteinsNature, 374
D. Logothetis, Y. Kurachi, J. Galper, E. Neer, D. Clapham (1987)
The beta gamma subunits of GTP-binding proteins activate the muscarinic K+ channel in heart.Nature, 325 6102
K. Wickman, J. Iñiguez-Lluhl, P. Davenport, R. Taussig, G. Krapivinsky, M. Linder, A. Gilman, D. Clapham (1994)
Recombinant G-protein beta gamma-subunits activate the muscarinic-gated atrial potassium channel.Nature, 368 6468
Y. Yanagawa, K. Sugahara, H. Kataoka, T. Kawaguchi, Y. Masubuchi, K. Chiba (1998)
FTY720, a novel immunosuppressant, induces sequestration of circulating mature lymphocytes by acceleration of lymphocyte homing in rats. II. FTY720 prolongs skin allograft survival by decreasing T cell infiltration into grafts but not cytokine production in vivo.Journal of immunology, 160 11
K. Liliom, G. Sun, M. Bünemann, T. Virág, N. Nusser, D. Baker, D. Wang, M. Fabian, B. Brandts, K. Bender, A. Eickel, K. Malik, D. Miller, D. Desiderio, G. Tigyi, L. Pott (2001)
Sphingosylphosphocholine is a naturally occurring lipid mediator in blood plasma: a possible role in regulating cardiac function via sphingolipid receptors.The Biochemical journal, 355 Pt 1
Moritz Biinemann, B. Brandts, Dagmar Heringdorft, C. Koppen, K. Jakobs, L. Pott (1995)
Activation of muscarinic K+ current in guinea‐pig atrial myocytes by sphingosine‐1‐phosphate.The Journal of Physiology, 489
S. Pyne, N. Pyne (2000)
Sphingosine 1-phosphate signalling via the endothelial differentiation gene family of G-protein-coupled receptors.Pharmacology & therapeutics, 88 2
D. Logothetis, D. Kim, J. Northup, E. Neer, D. Clapham (1988)
Specificity of action of guanine nucleotide-binding regulatory protein subunits on the cardiac muscarinic K+ channel.Proceedings of the National Academy of Sciences of the United States of America, 85 16
M. Gräler, E. Goetzl (2004)
The immunosuppressant FTY720 down‐regulates sphingosine 1‐phosphate G protein‐coupled receptorsThe FASEB Journal, 18
Y. Kurachi, T. Nakajima, T. Sugimoto (1986)
On the mechanism of activation of muscarinic K+ channels by adenosine in isolated atrial cells: involvement of GTP-binding proteinsPflügers Archiv, 407
D. Logothetis, Y. Kurachi, J. Galper, E. Neer, D. Clapham (1987)
The βγ subunits of GTP-binding proteins activate the muscarinic K+ channel in heartNature, 325
American Journal of Transplantation – Unpaywall
Published: Mar 1, 2005
Read and print from thousands of top scholarly journals.
Already have an account? Log in
Bookmark this article. You can see your Bookmarks on your DeepDyve Library.
To save an article, log in first, or sign up for a DeepDyve account if you don’t already have one.
Copy and paste the desired citation format or use the link below to download a file formatted for EndNote
Access the full text.
Sign up today, get DeepDyve free for 14 days.
All DeepDyve websites use cookies to improve your online experience. They were placed on your computer when you launched this website. You can change your cookie settings through your browser.