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Incidence, Mortality, and Prognostic Factors of Small Cell Carcinoma of the Cervix

Incidence, Mortality, and Prognostic Factors of Small Cell Carcinoma of the Cervix Incidence, Mortality, and Prognostic Factors of Small Cell Carcinoma of the Cervix Jergin Chen, MD, O. Kenneth Macdonald, MD, and David K. Gaffney, MD, PhD OBJECTIVE: To compare the incidence, mortality, and prognostic for survival in women with small cell carci- presentation of small cell carcinoma of the cervix with noma (P<.05). other histologies. CONCLUSION: Small cell carcinoma is a rare histology of cervical cancer associated with a worse prognosis and METHODS: From 1977 to 2003, 290 women with small a predilection for nodal and distant metastasis. The cell carcinoma of the cervix uteri were identified from the decrease in survival was marked in early-stage and node- Surveillance, Epidemiology, and End Results database. negative patients. Because of the high rates of nodal Also, 27,527 patients with squamous cell carcinoma of the involvement even with early-stage disease, multimodality cervix and 5,231 patients with adenocarcinoma of the treatment with radiotherapy and chemotherapy should cervix were identified for comparison. The annual inci- be considered. dence was calculated and examined for trend. Patient (Obstet Gynecol 2008;111:1394–402) and disease characteristics were compared among histol- ogies. Univariable analyses were conducted using the LEVEL OF EVIDENCE: II log-rank test. Multivariable analysis was performed using Cox regression. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Obstetrics & Gynecology Wolters Kluwer Health

Incidence, Mortality, and Prognostic Factors of Small Cell Carcinoma of the Cervix

Obstetrics & Gynecology , Volume 111 (6) – Jun 1, 2008

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References (38)

ISSN
0029-7844
eISSN
1873-233X
DOI
10.1097/AOG.0b013e318173570b
pmid
18515524
Publisher site
See Article on Publisher Site

Abstract

Incidence, Mortality, and Prognostic Factors of Small Cell Carcinoma of the Cervix Jergin Chen, MD, O. Kenneth Macdonald, MD, and David K. Gaffney, MD, PhD OBJECTIVE: To compare the incidence, mortality, and prognostic for survival in women with small cell carci- presentation of small cell carcinoma of the cervix with noma (P<.05). other histologies. CONCLUSION: Small cell carcinoma is a rare histology of cervical cancer associated with a worse prognosis and METHODS: From 1977 to 2003, 290 women with small a predilection for nodal and distant metastasis. The cell carcinoma of the cervix uteri were identified from the decrease in survival was marked in early-stage and node- Surveillance, Epidemiology, and End Results database. negative patients. Because of the high rates of nodal Also, 27,527 patients with squamous cell carcinoma of the involvement even with early-stage disease, multimodality cervix and 5,231 patients with adenocarcinoma of the treatment with radiotherapy and chemotherapy should cervix were identified for comparison. The annual inci- be considered. dence was calculated and examined for trend. Patient (Obstet Gynecol 2008;111:1394–402) and disease characteristics were compared among histol- ogies. Univariable analyses were conducted using the LEVEL OF EVIDENCE: II log-rank test. Multivariable analysis was performed using Cox regression.

Journal

Obstetrics & GynecologyWolters Kluwer Health

Published: Jun 1, 2008

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