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Incidence, Mortality, and Prognostic Factors of Small Cell Carcinoma of the Cervix Jergin Chen, MD, O. Kenneth Macdonald, MD, and David K. Gaffney, MD, PhD OBJECTIVE: To compare the incidence, mortality, and prognostic for survival in women with small cell carci- presentation of small cell carcinoma of the cervix with noma (P<.05). other histologies. CONCLUSION: Small cell carcinoma is a rare histology of cervical cancer associated with a worse prognosis and METHODS: From 1977 to 2003, 290 women with small a predilection for nodal and distant metastasis. The cell carcinoma of the cervix uteri were identified from the decrease in survival was marked in early-stage and node- Surveillance, Epidemiology, and End Results database. negative patients. Because of the high rates of nodal Also, 27,527 patients with squamous cell carcinoma of the involvement even with early-stage disease, multimodality cervix and 5,231 patients with adenocarcinoma of the treatment with radiotherapy and chemotherapy should cervix were identified for comparison. The annual inci- be considered. dence was calculated and examined for trend. Patient (Obstet Gynecol 2008;111:1394–402) and disease characteristics were compared among histol- ogies. Univariable analyses were conducted using the LEVEL OF EVIDENCE: II log-rank test. Multivariable analysis was performed using Cox regression.
Obstetrics & Gynecology – Wolters Kluwer Health
Published: Jun 1, 2008
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