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25-Hydroxyvitamin D Deficiency Is Associated With Inflammation-Linked Vascular Endothelial Dysfunction in Middle-Aged and Older Adults

25-Hydroxyvitamin D Deficiency Is Associated With Inflammation-Linked Vascular Endothelial... 25-Hydroxyvitamin D Deficiency Is Associated With Inflammation-Linked Vascular Endothelial Dysfunction in Middle-Aged and Older Adults Kristen L. Jablonski, Michel Chonchol, Gary L. Pierce, Ashley E. Walker, Douglas R. Seals Abstract—We tested the hypothesis that vascular endothelial function, assessed by endothelium-dependent dilation, is related to serum vitamin D status among middle-aged and older adults without clinical disease, and that this is linked to inflammation. Brachial artery flow-mediated dilation, a measure of endothelium-dependent dilation, was lower (P0.01) in vitamin D–insufficient (3.70.2%; serum 25-hydroxyvitamin D [25(OH)D]: 20 to 29 ng/mL; 621 years of age; n31; mean SE) and vitamin D–deficient (3.20.3%; 25(OH)D: 20 ng/mL; 632 years of age; n22) versus vitamin D–sufficient (4.60.4%; 25(OH)D: 29 ng/mL; 611 years of age; n22) subjects, whereas endothelium-independent dilation (brachial dilation to sublingual nitroglycerine) did not differ (P0.45). Among all subjects, brachial flow-mediated dilation was positively related to serum 25(OH)D (%: r0.35; P0.01) but not 1,25-dihydroxyvitamin D (r0.06; P0.61), the active form of vitamin D. Vascular endothelial cell expression of the proinflammatory transcription factor nuclear factor B was greater in deficient versus sufficient subjects (0.590.07 versus 0.440.05; P0.05), and inhibition of nuclear factor B (4 days oral salsalate) improved flow-mediated dilation to a greater extent in http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Hypertension Wolters Kluwer Health

25-Hydroxyvitamin D Deficiency Is Associated With Inflammation-Linked Vascular Endothelial Dysfunction in Middle-Aged and Older Adults

Seals, Douglas R.
Hypertension , Volume 57 (1) – Jan 1, 2011
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ISSN
0194-911X
eISSN
1524-4563
DOI
10.1161/HYPERTENSIONAHA.110.160929
pmid
21115878
Publisher site
See Article on Publisher Site

Abstract

25-Hydroxyvitamin D Deficiency Is Associated With Inflammation-Linked Vascular Endothelial Dysfunction in Middle-Aged and Older Adults Kristen L. Jablonski, Michel Chonchol, Gary L. Pierce, Ashley E. Walker, Douglas R. Seals Abstract—We tested the hypothesis that vascular endothelial function, assessed by endothelium-dependent dilation, is related to serum vitamin D status among middle-aged and older adults without clinical disease, and that this is linked to inflammation. Brachial artery flow-mediated dilation, a measure of endothelium-dependent dilation, was lower (P0.01) in vitamin D–insufficient (3.70.2%; serum 25-hydroxyvitamin D [25(OH)D]: 20 to 29 ng/mL; 621 years of age; n31; mean SE) and vitamin D–deficient (3.20.3%; 25(OH)D: 20 ng/mL; 632 years of age; n22) versus vitamin D–sufficient (4.60.4%; 25(OH)D: 29 ng/mL; 611 years of age; n22) subjects, whereas endothelium-independent dilation (brachial dilation to sublingual nitroglycerine) did not differ (P0.45). Among all subjects, brachial flow-mediated dilation was positively related to serum 25(OH)D (%: r0.35; P0.01) but not 1,25-dihydroxyvitamin D (r0.06; P0.61), the active form of vitamin D. Vascular endothelial cell expression of the proinflammatory transcription factor nuclear factor B was greater in deficient versus sufficient subjects (0.590.07 versus 0.440.05; P0.05), and inhibition of nuclear factor B (4 days oral salsalate) improved flow-mediated dilation to a greater extent in

Journal

Hypertension – Wolters Kluwer Health

Published: Jan 1, 2011

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