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Comparison of the pharmacokinetics of three concentrations of insulin aspart during continuous subcutaneous insulin infusion (CSII) in a pig model

Comparison of the pharmacokinetics of three concentrations of insulin aspart during continuous... ObjectivesThe aim of the study was to investigate the pharmacokinetic properties of insulin aspart (IAsp) in three different concentrations given as a continuous subcutaneous insulin infusion (CSII).MethodsA randomized cross-over study was performed in pigs, where IAsp U200, U100 or U20 was given for 8 h with the same total dose. Six pigs were included and blood was sampled during the CSII and 3 h after.Key findingsThe half-life (t1/2) was 24.3 (range 17.3–41.3), 28.8 (range 19.6–54.3) and 23.6 (range 17.4–36.8) min for U200, U100 and U20, respectively. The area under the curve per dose (AUC/D) was determined to be 51.2 ± 19.5, 52.3 ± 12.5 and 51.6 ± 6.7 pm × min/kg for U200, U100 and U20, respectively. The steady state plasma concentration (Css) was 57.5 ± 27.1, 54.3 ± 10.3 and 55.1 ± 8.0 pm (mean ± SD) for U200, U100 and U20, respectively. Time to steady state (Tss) was 110 ± 36, 98 ± 48 and 90 ± 27 min for U200, U100 and U20, respectively.ConclusionsIn conclusion, no significant difference was found in t1/2, AUC/D, Css or Tss between the three IAsp concentrations when given at a basal rate in CSII. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Pharmacy and Pharmacology Oxford University Press

Comparison of the pharmacokinetics of three concentrations of insulin aspart during continuous subcutaneous insulin infusion (CSII) in a pig model

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References (24)

Publisher
Oxford University Press
Copyright
© 2012 The Authors. JPP © 2012. Royal Pharmaceutical Society
ISSN
0022-3573
eISSN
2042-7158
DOI
10.1111/j.2042-7158.2012.01596.x
Publisher site
See Article on Publisher Site

Abstract

ObjectivesThe aim of the study was to investigate the pharmacokinetic properties of insulin aspart (IAsp) in three different concentrations given as a continuous subcutaneous insulin infusion (CSII).MethodsA randomized cross-over study was performed in pigs, where IAsp U200, U100 or U20 was given for 8 h with the same total dose. Six pigs were included and blood was sampled during the CSII and 3 h after.Key findingsThe half-life (t1/2) was 24.3 (range 17.3–41.3), 28.8 (range 19.6–54.3) and 23.6 (range 17.4–36.8) min for U200, U100 and U20, respectively. The area under the curve per dose (AUC/D) was determined to be 51.2 ± 19.5, 52.3 ± 12.5 and 51.6 ± 6.7 pm × min/kg for U200, U100 and U20, respectively. The steady state plasma concentration (Css) was 57.5 ± 27.1, 54.3 ± 10.3 and 55.1 ± 8.0 pm (mean ± SD) for U200, U100 and U20, respectively. Time to steady state (Tss) was 110 ± 36, 98 ± 48 and 90 ± 27 min for U200, U100 and U20, respectively.ConclusionsIn conclusion, no significant difference was found in t1/2, AUC/D, Css or Tss between the three IAsp concentrations when given at a basal rate in CSII.

Journal

Journal of Pharmacy and Pharmacology – Oxford University Press

Published: Feb 1, 2013

Keywords: basal rate; CSII; insulin aspart; pharmacokinetics

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