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Acute Irritation and Sensitization Potential of JP-8 Jet Fuel

Acute Irritation and Sensitization Potential of JP-8 Jet Fuel Acuto Irritation and Sensitization Potential of JP-8 Jet Fuel Title: Year Study Completed: 1984 E.R. Kinkead, S.A. Salins, and R.E. Wolfo Author (s): ManTech Environmental Technology, Inc. AffiliationlAddress: P.O. Box 31009, Dayton, OH 45431-0009 Petroleum-derived JP-8 Jet Fuel Compound Tested: (Market Place Sample) Military Specification (MIL-T-83133A) Dose Preparation: Neat Test and Results: pve Irrit atiog Protocol: New Zealand White Rabbits, 9 female, 2 to 3 kg; a topical anesthetic instilled in all rabbit eyes approximately 2 min prior to treatment; 0.1 mL into conjunctival sac, contralateral eye as untreated control; washed eyes flushed with lukewarm water for 1 min, 20 to 30 sec after treatment; Draize scoring technique'. Draize Scores: Unwashed (6 rabbit mean) 1 d 0.0, 2 d 0.0, 3 d 0.0, 4 d 0.0, 7 d 0.0; Washed (3 rabbit mean) 1 d 0.0, 2 d 0.0, 3 d 0.0, 4 d 0.0, 7 d 0,Q Results: Nonirritating skin Irri tation Protocol: New Zealand white Rabbits, 6 female, 2 to 3 kg; apply 0.5 mL to intact and abraded skin; cover with gauze pad, dental dam, and elastic tape; patches removed at 24 h; wipe clean and evaluate at 1 h, 1, 2, 3, and 7 days using Draize technique'. - Primary dermal irritation index = 1.29, slightly irritating. ennal Sensitizatio Protocol: Ten Hartley, male, albino guinea pigs, 6 to 8 Eeeks of age, N=10;'0.1 mL topically applied four times over a 10-day period. Following a two-week induction period, the animals were challenged with 0.1 mL of the test material on the clipped flank. Site scored for edema and erythema at 24 and 40 h; Draize technique. Results: 101 of tho animals showed a sensitization response; weak sensitizing potential. 'DRAIZE, J.H. (1959) Dermal Toxicitv. ADD raisal of the Safetv of Chemicals in Food, Druas, and Cosmetics. Assoc. of Food and Drug Officials of the U.S., Austin, TX, 49-51. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of the American College of Toxicology SAGE

Acute Irritation and Sensitization Potential of JP-8 Jet Fuel

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Publisher
SAGE
Copyright
Copyright © by SAGE Publications
ISSN
0730-0913
eISSN
1092-874X
DOI
10.3109/10915819209142093
Publisher site
See Article on Publisher Site

Abstract

Acuto Irritation and Sensitization Potential of JP-8 Jet Fuel Title: Year Study Completed: 1984 E.R. Kinkead, S.A. Salins, and R.E. Wolfo Author (s): ManTech Environmental Technology, Inc. AffiliationlAddress: P.O. Box 31009, Dayton, OH 45431-0009 Petroleum-derived JP-8 Jet Fuel Compound Tested: (Market Place Sample) Military Specification (MIL-T-83133A) Dose Preparation: Neat Test and Results: pve Irrit atiog Protocol: New Zealand White Rabbits, 9 female, 2 to 3 kg; a topical anesthetic instilled in all rabbit eyes approximately 2 min prior to treatment; 0.1 mL into conjunctival sac, contralateral eye as untreated control; washed eyes flushed with lukewarm water for 1 min, 20 to 30 sec after treatment; Draize scoring technique'. Draize Scores: Unwashed (6 rabbit mean) 1 d 0.0, 2 d 0.0, 3 d 0.0, 4 d 0.0, 7 d 0.0; Washed (3 rabbit mean) 1 d 0.0, 2 d 0.0, 3 d 0.0, 4 d 0.0, 7 d 0,Q Results: Nonirritating skin Irri tation Protocol: New Zealand white Rabbits, 6 female, 2 to 3 kg; apply 0.5 mL to intact and abraded skin; cover with gauze pad, dental dam, and elastic tape; patches removed at 24 h; wipe clean and evaluate at 1 h, 1, 2, 3, and 7 days using Draize technique'. - Primary dermal irritation index = 1.29, slightly irritating. ennal Sensitizatio Protocol: Ten Hartley, male, albino guinea pigs, 6 to 8 Eeeks of age, N=10;'0.1 mL topically applied four times over a 10-day period. Following a two-week induction period, the animals were challenged with 0.1 mL of the test material on the clipped flank. Site scored for edema and erythema at 24 and 40 h; Draize technique. Results: 101 of tho animals showed a sensitization response; weak sensitizing potential. 'DRAIZE, J.H. (1959) Dermal Toxicitv. ADD raisal of the Safetv of Chemicals in Food, Druas, and Cosmetics. Assoc. of Food and Drug Officials of the U.S., Austin, TX, 49-51.

Journal

Journal of the American College of Toxicology – SAGE

Published: Nov 1, 1992

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