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References (102)
-
V Buchanan-Wollaston (1997)
The molecular biology of leaf senescenceJ Exp Bot., 48
-
S Li, Y Park, S Duraisingham, FH Strobel, N Khan, QA Soltow, DP Jones, B Pulendran (2013)
Predicting network activity from high throughput metabolomicsPLoS Comput Biol., 9
-
N Jiang, YS Lee, E Mukundi, F Gomez-Cano, L Rivero, E Grotewold (2020)
Diversity of genetic lesions characterizes new Arabidopsis flavonoid pigment mutant alleles from T-DNA collectionsPlant Sci., 291
-
T Kichey, B Hirel, E Heumez, F Dubois, J Le Gouis (2007)
In winter wheat (Triticum aestivum L.), post-anthesis nitrogen uptake and remobilisation to the grain correlates with agronomic traits and nitrogen physiological markersField Crops Res., 102
-
H Thomas, CJ Howarth (2000)
Five ways to stay greenJ Exp Bot., 51
-
S Shimada, BR Hoffmann, C Yang, T Kurth, AS Greene, M Liang, RK Dash, AW Cowley (2023)
Metabolic responses of normal rat kidneys to a high salt intakeFunction, 4
-
RS Sekhon, K Childs, N Santoro, C Foster, CR Buell, N de Leon, SM Kaeppler (2012)
Transcriptional and metabolic analysis of senescence induced by preventing pollination in maizePlant Physiol., 159
-
J Chicote, VJ Yuste, J Boix, J Ribas (2020)
Cell death triggered by the autophagy inhibitory drug 3-methyladenine in growing conditions proceeds with DNA damageFront Pharmacol., 11
-
DR Jordan, CH Hunt, AW Cruickshank, AK Borrell, RG Henzell (2012)
The relationship between the stay-green trait and grain yield in elite sorghum hybrids grown in a range of environmentsCrop Sci., 52
-
L Emebiri (2013)
QTL dissection of the loss of green colour during post-anthesis grain maturation in two-rowed barleyTheor Appl Genet., 126
-
V Joshi, KM Laubengayer, N Schauer, AR Fernie, G Jander (2007)
Two Arabidopsis threonine aldolases are nonredundant and compete with threonine deaminase for a common substrate poolPlant Cell, 18
-
P Langfelder, S Horvath (2008)
WGCNA: an R package for weighted correlation network analysisBMC Bioinformatics, 9
-
D Urano, A Colaneri, AM Jones (2014)
Gα modulates salt-induced cellular senescence and cell division in rice and maizeJ Exp Bot., 65
-
D Liebsch, M Juvany, Z Li, HL Wang, A Ziolkowska, D Chrobok, C Boussardon, X Wen, SR Law, H Janečková (2022)
Metabolic control of arginine and ornithine levels paces the progression of leaf senescencePlant Physiol., 189
-
Y Guo, G Ren, K Zhang, Z Li, Y Miao, H Guo (2021)
Leaf senescence: progression, regulation, and applicationMol Hortic., 1
-
MG Neuffer, EH Coe, SR Wessler (1997)
Mutants of maize
-
J Todd, S Screen, J Crowley, J Peng, S Andersen, T Brown, Q Qi, B Fabbri, SMG Duff (2008)
Identification and characterization of four distinct asparagine synthetase (AsnS) genes in maize (Zea mays L.)Plant Sci., 175
-
(2024)
Inventory of U.S. Greenhouse gas emissions and sinks: 1990–2022
-
S Smeekens, J Ma, J Hanson, F Rolland (2010)
Sugar signals and molecular networks controlling plant growthCurr Opin Plant Biol., 13
-
M Giera, A Aisporna, W Uritboonthai, L Hoang, RJE Derks, KM Joseph, ES Baker, G Siuzdak (2024)
XCMS-METLIN: data-driven metabolite, lipid, and chemical analysisMol Syst Biol., 20
-
E Grotewold, BJ Drummond, B Bowen, T Peterson (1994)
The myb-homologous P gene controls phlobaphene pigmentation in maize floral organs by directly activating a flavonoid biosynthetic gene subsetCell, 76
-
ML Falcone Ferreyra, SP Rius, P Casati (2012)
Flavonoids: biosynthesis, biological functions, and biotechnological applicationsFront Plant Sci., 3
-
N Chibane, M Caicedo, S Martinez, P Marcet, P Revilla, B Ordás (2021)
Relationship between delayed leaf senescence (stay-green) and agronomic and physiological characters in maize (Zea mays LAgronomy, 11
-
J Schröder (1997)
A family of plant-specific polyketide synthases: facts and predictionsTrends Plant Sci., 2
-
M Watanabe, S Balazadeh, T Tohge, A Erban, P Giavalisco, J Kopka, B Mueller-Roeber, AR Fernie, R Hoefgen (2013)
Comprehensive dissection of spatiotemporal metabolic shifts in primary, secondary, and lipid metabolism during developmental senescence in ArabidopsisPlant Physiol., 162
-
H Thomas (2013)
Senescence, ageing and death of the whole plantNew Phytol., 197
-
F Yang, W Li, N Jiang, H Yu, K Morohashi, WZ Ouma, DE Morales-Mantilla, FA Gomez-Cano, E Mukundi, LD Prada-Salcedo (2017)
A maize gene regulatory network for phenolic metabolismMol Plant, 10
-
M Sharma, M Cortes-Cruz, KR Ahern, M McMullen, TP Brutnell, S Chopra (2011)
Identification of the pr1 gene product completes the anthocyanin biosynthesis pathway of maizeGenetics, 188
-
Y Yu, Y Qi, J Xu, X Dai, J Chen, C-H Dong, F Xiang (2021)
Arabidopsis WRKY71 regulates ethylene-mediated leaf senescence by directly activating EIN2, ORE1 and ACS2 genesPlant J., 107
-
X Fan, Z Fan, Z Yang, T Huang, Y Tong, D Yang, X Mao, M Yang (2022)
Flavonoids-natural gifts to promote health and longevityInt J Mol Sci., 23
-
DR Holding, RB Meeley, J Hazebroek, D Selinger, F Gruis, R Jung, BA Larkins (2010)
Identification and characterization of the maize arogenate dehydrogenase gene familyJ Exp Bot., 61
-
R Kumar, E Bishop, WC Bridges, N Tharayil, RS Sekhon (2019)
Sugar partitioning and source–sink interaction are key determinants of leaf senescence in maizePlant Cell Environ., 42
-
BW Shirley, WL Kubasek, G Storz, E Bruggemann, M Koornneef, FM Ausubel, HM Goodman (1995)
Analysis of Arabidopsis mutants deficient in flavonoid biosynthesisPlant J., 8
-
Z Pang, J Chong, G Zhou, DA de Lima Morais, L Chang, M Barrette, C Gauthier, P-É Jacques, S Li, J Xia (2021)
MetaboAnalyst 5.0: narrowing the gap between raw spectra and functional insightsNucleic Acids Res., 49
-
PO Lim, HJ Kim, HG Nam (2007)
Leaf senescenceAnnu Rev Plant Biol., 58
-
EA Lee, M Tollenaar (2007)
Physiological basis of successful breeding strategies for maize grain yieldCrop Sci., 47
-
JB Hollick, VL Chandler (2001)
Genetic factors required to maintain repression of a paramutagenic maize pl1 alleleGenetics, 157
-
A Aharoni, R Goodacre, AR Fernie (2023)
Plant and microbial sciences as key drivers in the development of metabolomics researchProc Natl Acad Sci U S A., 120
-
P Gregersen, A Culetic, L Boschian, K Krupinska (2013)
Plant senescence and crop productivityPlant Mol Biol., 82
-
A Wingler, T Roitsch (2008)
Metabolic regulation of leaf senescence: interactions of sugar signalling with biotic and abiotic stress responsesPlant Biol., 10
-
L Zhang, D Becker (2015)
Connecting proline metabolism and signaling pathways in plant senescenceFront Plant Sci., 6
-
M Sindelar, GJ Patti (2020)
Chemical discovery in the era of metabolomicsJ Am Chem Soc., 142
-
M Popelka (2012)
Genetic architecture of stay-green in maize
-
J Xue, D Lu, S Wang, Z Lu, W Liu, X Wang, Z Fang, X He (2021)
Integrated transcriptomic and metabolomic analysis provides insight into the regulation of leaf senescence in riceSci Rep., 11
-
H Ougham, I Armstead, C Howarth, I Galyuon, I Donnison, H Thomas (2007)
Annual plant reviews
-
F Li, T Chung, JG Pennington, ML Federico, HF Kaeppler, SM Kaeppler, MS Otegui, RD Vierstra (2015)
Autophagic recycling plays a central role in maize nitrogen remobilizationPlant Cell, 27
-
A Martin, J Lee, T Kichey, D Gerentes, M Zivy, C Tatout, F Dubois, T Balliau, B Valot, M Davanture (2006)
Two cytosolic glutamine synthetase isoforms of maize are specifically involved in the control of grain productionPlant Cell, 18
-
P Casati, V Walbot (2005)
Differential accumulation of maysin and rhamnosylisoorientin in leaves of high-altitude landraces of maize after UV-B exposurePlant Cell Environ., 28
-
K Thomazeau, G Curien, R Dumas, V Biou (2001)
Crystal structure of threonine synthase from Arabidopsis thalianaProtein Sci., 10
-
K Saito, K Yonekura-Sakakibara, R Nakabayashi, Y Higashi, M Yamazaki, T Tohge, AR Fernie (2013)
The flavonoid biosynthetic pathway in Arabidopsis: structural and genetic diversityPlant Physiol Biochem., 72
-
NG Mahieu, GJ Patti (2017)
Systems-level annotation of a metabolomics data set reduces 25 000 features to fewer than 1000 unique metabolitesAnal Chem., 89
-
K Dührkop, L-F Nothias, M Fleischauer, R Reher, M Ludwig, MA Hoffmann, D Petras, WH Gerwick, J Rousu, PC Dorrestein (2021)
Systematic classification of unknown metabolites using high-resolution fragmentation mass spectraNat Biotechnol., 39
-
R Kumar, MS Brar, B Kunduru, AJ Ackerman, Y Yang, F Luo, CA Saski, WC Bridges, N de Leon, C McMahan (2023)
Genetic architecture of source-sink-regulated senescence in maizePlant Physiol., 193
-
TL Slewinski, R Meeley, DM Braun (2009)
Sucrose transporter1 functions in phloem loading in maize leavesJ Exp Bot., 60
-
X Liu, L Wu, Y Si, Y Zhai, M Niu, M Han, T Su (2024)
Regulating effect of exogenous α-ketoglutarate on ammonium assimilation in poplarMolecules, 29
-
A Sgarbossa, D Giacomazza, M Di Carlo (2015)
Ferulic acid: a hope for Alzheimer's disease therapy from plantsNutrients, 7
-
C Masclaux-Daubresse, M Reisdorf-Cren, M Orsel (2008)
Leaf nitrogen remobilisation for plant development and grain fillingPlant Biol., 10
-
PK Sandhu, E Leonard, V Nandula, N Tharayil (2023)
Global metabolome of palmer amaranth (Amaranthus palmeri) populations highlights the specificity and inducibility of phytochemical responses to abiotic stressJ Agric Food Chem., 71
-
EA Vidal, RA Gutiérrez (2008)
A systems view of nitrogen nutrient and metabolite responses in ArabidopsisCurr Opin Plant Biol., 11
-
Y Liu, J Qu, L Zhang, X Xu, G Wei, Z Zhao, M Ren, M Cao (2019)
Identification and characterization of the TCA cycle genes in maizeBMC Plant Biol., 19
-
F Zhu, S Alseekh, K Koper, H Tong, Z Nikoloski, T Naake, H Liu, J Yan, Y Brotman, W Wen (2022)
Genome-wide association of the metabolic shifts underpinning dark-induced senescence in ArabidopsisPlant Cell, 34
-
H Fahnenstich, M Saigo, M Niessen, M Zanor, CS Andreo, AR Fernie, M Drincovich, U-I Flügge, V Maurino (2007)
Alteration of organic acid metabolism in Arabidopsis overexpressing the maize C4 NADP-malic enzyme causes accelerated senescence during extended darknessPlant Physiol., 145
-
ML Falcone-Ferreyra, MI Casas, J Questa, L Herrera, S Deblasio, J Wang, D Jackson, E Grotewold, P Casati (2012)
Evolution and expression of tandem duplicated maize flavonol synthase genesFront Plant Sci., 3
-
E Schulz, T Tohge, E Zuther, AR Fernie, DK Hincha (2016)
Flavonoids are determinants of freezing tolerance and cold acclimation in Arabidopsis thalianaSci Rep., 6
-
MK Monaco, TZ Sen, PD Dharmawardhana, L Ren, M Schaeffer, S Naithani, V Amarasinghe, J Thomason, L Harper, J Gardiner (2013)
Maize metabolic network construction and transcriptome analysisPlant Genome, 6
-
J Bresson, S Bieker, L Riester, J Doll, U Zentgraf (2018)
A guideline for leaf senescence analyses: from quantification to physiological and molecular investigationsJ Exp Bot., 69
-
L Xuan, C Zhang, T Yan, D Wu, N Hussain, Z Li, M Chen, J Pan, L Jiang (2018)
TRANSPARENT TESTA 4-mediated flavonoids negatively affect embryonic fatty acid biosynthesis in ArabidopsisPlant Cell Environ., 41
-
ML Mayta, MR Hajirezaei, N Carrillo, AF Lodeyro (2019)
Leaf senescence: the chloroplast connection comes of agePlants (Basel), 8
-
RR da Silva, PC Dorrestein, RA Quinn (2015)
Illuminating the dark matter in metabolomicsProc Natl Acad Sci U S A., 112
-
DN Duvick, JSC Smith, M Cooper (2010)
Plant breeding reviews
-
JD Williamson, DB Jennings, W-W Guo, DM Pharr, M Ehrenshaft (2002)
Sugar alcohols, salt stress, and fungal resistance: polyols—multifunctional plant protection?J Am Soc Hortic Sci., 127
-
W Luo, MH Li, J Sardans, XT Lü, C Wang, J Peñuelas, Z Wang, XG Han, Y Jiang (2017)
Carbon and nitrogen allocation shifts in plants and soils along aridity and fertility gradients in grasslands of ChinaEcol Evol., 7
-
Q Wang, M Liu, S Quan, Q Shi, T Tian, H Zhang, H Wang, G Li (2023)
FAR-RED ELONGATED HYPOCOTYL3 increases leaf longevity by delaying senescence in ArabidopsisPlant Cell Environ., 46
-
MA Aljaziri, D Hajjar, A-H Emwas, AA Makki, M Jaremko (2022)
Phytochemical influence of Salvia officinalis L. From Saudi Arabia and Palestine on oxidation and HIV viral loadJ Pharmacogn Nat Prod., 8
-
LD Noodén, LD Noodén, SC Leopold (1988)
Senescence and aging in plants
-
K Vijayalakshmi, A Fritz, G Paulsen, G Bai, S Pandravada, B Gill (2010)
Modeling and mapping QTL for senescence-related traits in winter wheat under high temperatureMol Breed., 26
-
K Ichimura, S Yoshioka, T Yamada (2016)
Exogenous mannitol treatment stimulates bud development and extends vase life of cut snapdragon flowersPostharvest Biol Technol., 113
-
M Bertolini, N Di Fonzo, E Gentinetta, M Motto, A Verdebio, F Salamini, C Fogher, C Lorenzoni, T Maggiore, A Bianchi (1983)
Lo876o2. Linea pura di mais “high lysine” sviluppata in ItaliaSementi Elette, 19
-
H Yokoi, M Furukawa, J Wang, Y Aoki, R Raju, Y Ikuyo, M Yamada, Y Shikama, K Matsushita (2023)
Erythritol can inhibit the expression of senescence molecules in mouse gingival tissues and human gingival fibroblastsNutrients, 15
-
S Lei, B Huang (2022)
Metabolic regulation of α-ketoglutarate associated with heat tolerance in perennial ryegrassPlant Physiol Biochem., 190
-
T Yu, X Lu, Y Bai, X Mei, Z Guo, C Liu, Y Cai (2019)
Overexpression of the maize transcription factor ZmVQ52 accelerates leaf senescence in ArabidopsisPLoS One, 14
-
EL Schymanski, J Jeon, R Gulde, K Fenner, M Ruff, HP Singer, J Hollender (2014)
Identifying small molecules via high resolution mass spectrometry: communicating confidenceEnviron Sci Technol., 48
-
O Fiehn (2016)
Metabolomics by gas chromatography–mass spectrometry: combined targeted and untargeted profilingCurr Protoc Mol Biol., 114
-
M Kante, P Revilla, M De La Fuente, M Caicedo, B Ordás (2016)
Stay-green QTLs in temperate elite maizeEuphytica, 207
-
MR White, MA Mikel, N de Leon, SM Kaeppler (2020)
Diversity and heterotic patterns in North American proprietary dent maize germplasmCrop Sci., 60
-
JH Schippers, R Schmidt, C Wagstaff, HC Jing (2015)
Living to die and dying to live: the survival strategy behind leaf senescencePlant Physiol., 169
-
HK Dooner, TP Robbins, RA Jorgensen (1991)
Genetic and developmental control of anthocyanin biosynthesisAnnu Rev Genet., 25
-
S Alseekh, A Aharoni, Y Brotman, K Contrepois, J D'Auria, JCE Ewald J, PD Fraser, P Giavalisco, RD Hall, M Heinemann (2021)
Mass spectrometry-based metabolomics: a guide for annotation, quantification and best reporting practicesNat Methods., 18
-
L Perez-Fons, TM Ovalle, M Drapal, MA Ospina, A Gkanogiannis, A Bohorquez-Chaux, LA Becerra Lopez-Lavalle, PD Fraser (2023)
Integrated genetic and metabolic characterization of Latin American cassava (Manihot esculenta) germplasmPlant Physiol., 192
-
DK Großkinsky, SJ Syaifullah, T Roitsch (2017)
Integration of multi-omics techniques and physiological phenotyping within a holistic phenomics approach to study senescence in model and crop plantsJ Exp Bot., 69
-
P Shannon, A Markiel, O Ozier, NS Baliga, JT Wang, D Ramage, N Amin, B Schwikowski, T Ideker (2003)
Cytoscape: a software environment for integrated models of biomolecular interaction networksGenome Res., 13
-
W Li, H Zhang, X Li, F Zhang, C Liu, Y Du, X Gao, Z Zhang, X Zhang, Z Hou (2017)
Intergrative metabolomic and transcriptomic analyses unveil nutrient remobilization events in leaf senescence of tobaccoSci Rep., 7
-
SC Lo, RL Nicholson (1998)
Reduction of light-induced anthocyanin accumulation in inoculated sorghum mesocotyls. Implications for a compensatory role in the defense responsePlant Physiol., 116
-
M Havé, A Marmagne, F Chardon, C Masclaux-Daubresse (2016)
Nitrogen remobilization during leaf senescence: lessons from Arabidopsis to cropsJ Exp Bot., 68
-
Y Zhang, Z Wu, M Feng, J Chen, M Qin, W Wang, Y Bao, Q Xu, Y Ye, C Ma (2021)
The circadian-controlled PIF8-BBX28 module regulates petal senescence in rose flowers by governing mitochondrial ROS homeostasis at nightPlant Cell, 33
-
R Diebold, J Schuster, K Däschner, S Binder (2002)
The branched-chain amino acid transaminase gene family in Arabidopsis encodes plastid and mitochondrial proteinsPlant Physiol., 129
-
H Thomas, H Ougham (2014)
The stay-green traitJ Exp Bot., 65
-
J Zhang, KA Fengler, JL Van Hemert, R Gupta, N Mongar, J Sun, WB Allen, Y Wang, B Weers, H Mo (2019)
Identification and characterization of a novel stay-green QTL that increases yield in maizePlant Biotechnol J., 17
-
W Pooma, C Gersos, E Grotewold (2002)
Transposon insertions in the promoter of the Zea mays a1 gene differentially affect transcription by the Myb factors P and C1Genetics, 161
-
V Buchanan-Wollaston, T Page, E Harrison, E Breeze, PO Lim, HG Nam, J-F Lin, S-H Wu, J Swidzinski, K Ishizaki (2005)
Comparative transcriptome analysis reveals significant differences in gene expression and signalling pathways between developmental and dark/starvation-induced senescence in ArabidopsisPlant J., 42
-
R Huang, C Li, M Guo, H Xu, S Zhang, M Wang, Y Ge (2022)
Caffeic acid regulated respiration, ethylene and reactive oxygen species metabolism to suppress senescence of Malus domesticaPostharvest Biol Technol., 194
-
RS Sekhon, C Saski, R Kumar, B Flinn, F Luo, TM Beissinger, AJ Ackerman, MW Breitzman, WC Bridges, N de Leon (2019)
Integrated genome-scale analysis identifies novel genes and networks underlying senescence in maizePlant Cell, 31
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- Oxford University Press
- Copyright
- © The Author(s) 2025. Published by Oxford University Press on behalf of American Society of Plant Biologists. All rights reserved. For commercial re-use, please contact [email protected] for reprints and translation rights for reprints. All other permissions can be obtained through our RightsLink service via the Permissions link on the article page on our site—for further information please contact [email protected].
- ISSN
- 1040-4651
- eISSN
- 1532-298X
- DOI
- 10.1093/plcell/koaf176
- Publisher site
- See Article on Publisher Site
Abstract
Delayed leaf senescence (staygreen) is an important agronomic trait associated with enhanced resilience to abiotic and biotic stresses and improved productivity. While senescence induces large-scale metabolomic changes, the characterization of metabolic shifts and the identification of key metabolites and pathways determining the staygreen trait remain limited. Here, we generated a temporal map of the physiological and metabolic variation in genetically diverse maize (Zea mays) inbred lines spanning the staygreen spectrum. Integrated analysis of the captured phenotypic variation revealed substantial metabolic perturbations and identified 42 primary and 141 specialized leaf metabolites. Non-staygreen inbred lines were enriched in primary metabolites represented by sugar alcohols (notably mannitol and erythritol), and amino acids including phenylalanine and arginine. In contrast, the staygreen inbred lines accumulated higher levels of specialized metabolites, primarily phenylpropanoids. Metabolome-to-genome mapping identified 56 candidate genes expressed in adult maize leaves responsible for the metabolic changes that occur during senescence. Reverse genetics validated the role of naringenin chalcone and eriodictyol in maize and Arabidopsis thaliana leaf senescence, demonstrating a conserved function of these flavonoids across monocots and dicots. Together, our results reveal the coordinated physiological and metabolic programs that govern senescence and provide a curated set of metabolites and genes underlying this complex process.
Journal
The Plant Cell – Oxford University Press
Published: Jul 22, 2025