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Echinococcus multilocularis metacestode extract triggers human basophils to release interleukin‐4

Echinococcus multilocularis metacestode extract triggers human basophils to release interleukin‐4 SUMMARY Infections with parasitic helminths are associated with a T helper 2 (Th2) immune response and IgE production. The underlying mechanism, however, is only partially understood. Recently we have isolated a protein from extracts of Schistosoma mansoni eggs that triggers human basophils from non‐sensitized donors to release interleukin‐4 (IL‐4), the key cytokine of a Th2 response. We called this protein IPSE (for IL‐4‐inducing principle from Schistosoma mansoni eggs). Supposing that IPSE‐like IL‐4‐inducing activities might be a general principle shared among different helminth species, we investigated extracts from the cestode E. multilocularis for its effect on human basophils. Our results showed that extracts from metacestodes of E. multilocularis cause basophil degranulation, as well as the secretion of histamine, IL‐4 and IL‐13, in a dose‐dependent manner. IgE stripping and resensitization of basophils indicated that the mechanism of IL‐4 induction requires the presence of IgE on the cells. Since analogous properties have been demonstrated earlier for IPSE, we think that S. mansoni and E. multilocularis may induce a Th2 response in their hosts via a related mechanism, namely, by the induction of IL‐4 release from basophils. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Parasite Immunology Wiley

Echinococcus multilocularis metacestode extract triggers human basophils to release interleukin‐4

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References (41)

Publisher
Wiley
Copyright
Copyright © 2004 Wiley Subscription Services, Inc., A Wiley Company
ISSN
0141-9838
eISSN
1365-3024
DOI
10.1111/j.0141-9838.2004.00724.x
pmid
15752116
Publisher site
See Article on Publisher Site

Abstract

SUMMARY Infections with parasitic helminths are associated with a T helper 2 (Th2) immune response and IgE production. The underlying mechanism, however, is only partially understood. Recently we have isolated a protein from extracts of Schistosoma mansoni eggs that triggers human basophils from non‐sensitized donors to release interleukin‐4 (IL‐4), the key cytokine of a Th2 response. We called this protein IPSE (for IL‐4‐inducing principle from Schistosoma mansoni eggs). Supposing that IPSE‐like IL‐4‐inducing activities might be a general principle shared among different helminth species, we investigated extracts from the cestode E. multilocularis for its effect on human basophils. Our results showed that extracts from metacestodes of E. multilocularis cause basophil degranulation, as well as the secretion of histamine, IL‐4 and IL‐13, in a dose‐dependent manner. IgE stripping and resensitization of basophils indicated that the mechanism of IL‐4 induction requires the presence of IgE on the cells. Since analogous properties have been demonstrated earlier for IPSE, we think that S. mansoni and E. multilocularis may induce a Th2 response in their hosts via a related mechanism, namely, by the induction of IL‐4 release from basophils.

Journal

Parasite Immunology – Wiley

Published: Oct 1, 2004

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