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Relationship Between Short-Term Blood Pressure Variability and Large-Artery Stiffness in Human Hypertension Findings From 2 Large Databases

Relationship Between Short-Term Blood Pressure Variability and Large-Artery Stiffness in Human... Relationship Between Short-Term Blood Pressure Variability and Large-Artery Stiffness in Human Hypertension Findings From 2 Large Databases Giuseppe Schillaci, Grzegorz Bilo, Giacomo Pucci, Stéphane Laurent, Isabelle Macquin-Mavier, Pierre Boutouyrie, Francesca Battista, Laura Settimi, Gaëlle Desamericq, Guillaume Dolbeau, Andrea Faini, Paolo Salvi, Elmo Mannarino, Gianfranco Parati Abstract—Short-term blood pressure (BP) variability predicts cardiovascular complications in hypertension, but its association with large-artery stiffness is poorly understood and confounded by methodologic issues related to the assessment of BP variations over 24 hours. Carotid-femoral pulse wave velocity (cfPWV) and 24-hour ambulatory BP were measured in 911 untreated, nondiabetic patients with uncomplicated hypertension (learning population) and in 2089 mostly treated hyperten- sive patients (83% treated, 25% diabetics; test population). Short-term systolic BP (SBP) variability was calculated as the following: (1) SD of 24-hour, daytime, or nighttime SBP; (2) weighted SD of 24-hour SBP; and (3) average real variability (ARV), that is, the average of the absolute differences between consecutive SBP measurements over 24 hours. In the learning population, all of the measures of SBP variability showed a direct correlation with cfPWV (SD of 24-hour, daytime, and nighttime SBP, r0.17/0.19/0.13; weighted SD of 24-hour SBP, r0.21; ARV, r0.26; all P0.001). The relationship between cfPWV and http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Hypertension Wolters Kluwer Health

Relationship Between Short-Term Blood Pressure Variability and Large-Artery Stiffness in Human Hypertension Findings From 2 Large Databases

Parati, Gianfranco
Hypertension , Volume 60 (2) – Aug 1, 2012
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References (55)

Copyright
© 2012 American Heart Association, Inc.
ISSN
0194-911X
eISSN
1524-4563
DOI
10.1161/HYPERTENSIONAHA.112.197491
pmid
22753222
Publisher site
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Abstract

Relationship Between Short-Term Blood Pressure Variability and Large-Artery Stiffness in Human Hypertension Findings From 2 Large Databases Giuseppe Schillaci, Grzegorz Bilo, Giacomo Pucci, Stéphane Laurent, Isabelle Macquin-Mavier, Pierre Boutouyrie, Francesca Battista, Laura Settimi, Gaëlle Desamericq, Guillaume Dolbeau, Andrea Faini, Paolo Salvi, Elmo Mannarino, Gianfranco Parati Abstract—Short-term blood pressure (BP) variability predicts cardiovascular complications in hypertension, but its association with large-artery stiffness is poorly understood and confounded by methodologic issues related to the assessment of BP variations over 24 hours. Carotid-femoral pulse wave velocity (cfPWV) and 24-hour ambulatory BP were measured in 911 untreated, nondiabetic patients with uncomplicated hypertension (learning population) and in 2089 mostly treated hyperten- sive patients (83% treated, 25% diabetics; test population). Short-term systolic BP (SBP) variability was calculated as the following: (1) SD of 24-hour, daytime, or nighttime SBP; (2) weighted SD of 24-hour SBP; and (3) average real variability (ARV), that is, the average of the absolute differences between consecutive SBP measurements over 24 hours. In the learning population, all of the measures of SBP variability showed a direct correlation with cfPWV (SD of 24-hour, daytime, and nighttime SBP, r0.17/0.19/0.13; weighted SD of 24-hour SBP, r0.21; ARV, r0.26; all P0.001). The relationship between cfPWV and

Journal

Hypertension – Wolters Kluwer Health

Published: Aug 1, 2012

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