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META-ANALYSIS Preoperative Ultrasound-Guided Needle Biopsy of Axillary Nodes in Invasive Breast Cancer Meta-Analysis of Its Accuracy and Utility in Staging the Axilla ∗ ∗ Nehmat Houssami, MBBS, PhD, Stefano Ciatto, MD,† Robin M. Turner, PhD, Hiram S. Cody, III, MD,‡ and Petra Macaskill, PhD on the use of systemic therapy. Sentinel node biopsy (SNB) is the stan- Objective: Systematic evidence synthesis of ultrasound-guided needle biopsy dard initial surgical approach for staging the axilla in most women; (UNB) of axillary nodes in breast cancer. those found to have sentinel node metastases will generally undergo Summary Background Data: Women affected by invasive breast cancer further surgery, a completion axillary node dissection (AND). The undergo initial staging with sentinel node biopsy, generally progressing to ax- past decade has seen the introduction of ultrasound-guided needle illary node dissection (AND) if metastases are found. Preoperative UNB biopsy (UNB) in preoperative evaluation of axillary nodes to po- can potentially identify and triage women with node metastases directly tentially identify and triage women with node metastases on UNB to AND. 1–7 directly to AND. Although studies have examined, and in some Methods: Review and meta-analysis of studies reporting UNB accuracy: we 1–6 instances advocated, the adoption
Annals of Surgery – Wolters Kluwer Health
Published: Aug 1, 2011
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