Access the full text.
Sign up today, get DeepDyve free for 14 days.
Loading next page...
/lp/oxford-university-press/potentiation-of-methicillin-activity-against-methicillin-resistant-EUti90ZASi
References (16)
-
Hiroyuki Haraguchi1, Shingo Oike1, Hisashi Muroi1, Isao Kubo2 (1996)
Mode of Antibacterial Action of Totarol, a Diterpene from Podocarpus nagiPlanta Medica, 62
-
I. Powell, D. Tulloch, A. Hillier, B. Davidson (1992)
Phage DNA synthesis and host DNA degradation in the life cycle of Lactococcus lactis bacteriophage c6A.Journal of general microbiology, 138 5
-
H. Towbin, T. Staehelin, J. Gordon (1979)
Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications.Proceedings of the National Academy of Sciences of the United States of America, 76 9
-
J. Bendall, R. Cambie (1995)
Totarol: a Non-Conventional DiterpenoidAustralian Journal of Chemistry, 48
-
A. Panlilio, D. Culver, R. Gaynes, Shailen Banerjee, T. Henderson, James Tolson, W. Martone (1992)
Methicillin-resistant Staphylococcus aureus in U.S. hospitals, 1975-1991.Infection control and hospital epidemiology, 13 10
-
Koji Kobayashi, C. Nishino, M. Fukushima, Y. Shiobara, M. Kodama (1988)
Antibacterial Activity of Pisiferic Acid and Its Derivatives against Gram-negative and-positive BacteriaAgricultural and biological chemistry, 52
-
G. Archer, D. Niemeyer (1994)
Origin and evolution of DNA associated with resistance to methicillin in staphylococci.Trends in microbiology, 2 10
-
H. Muroi, I. Kubo (1996)
Antibacterial activity of anacardic acid and totarol, alone and in combination with methicillin, against methicillin-resistant Staphylococcus aureus.The Journal of applied bacteriology, 80 4
-
P. Murray, E. Baron, J. Jorgensen, M. Landry, M. Pfaller (1975)
Manual of clinical microbiologyMycologia, 67
-
M. Lessler (1969)
Oxygen electrode measurements in biochemical analysis.Methods of biochemical analysis, 17
-
Isao Kubo, H. Muroi, M. Himejima (1992)
Antibacterial activity of totarol and its potentiation.Journal of natural products, 55 10
-
U. Laemmli (1970)
Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4Nature, 227
-
A. Tomasz (1994)
Benefit and risk in the beta-lactam antibiotic-resistance strategies of Streptococcus pneumoniae and Staphylococcus aureus.Trends in microbiology, 2 10
-
Kobayashi Koji, Kuroda Kazufuni, Shinomiya Tomoyuki, Nishino Chikao, Ohya Junichi, Sato Shigeru (1989)
Effect of pisiferic acid and its derivatives on cytotoxicity macromolecular synthesis and dna polymerase α of hela cellsInternational Journal of Biochemistry, 21
-
H. Muroi, I. Kubo (1994)
Bactericidal Effects of Anacardic Acid and Totarol on Methicillin-resistant Staphylococcus aureus (MRSA)Bioscience, Biotechnology, and Biochemistry, 58
-
(1989)
233^239 239 D ow naded rom http/academ ic.p.com fem sle/article-at/179/2/233/447691 by gest on
- Publisher
- Oxford University Press
- Copyright
- © 1999 Federation of European Microbiological Societies.
- ISSN
- 0378-1097
- eISSN
- 1574-6968
- DOI
- 10.1111/j.1574-6968.1999.tb08733.x
- pmid
- 10518721
- Publisher site
- See Article on Publisher Site
Abstract
AbstractTotarol is a diterpene compound extracted from the totara tree. Totarol and eight other diterpenes were found to potentiate methicillin, one reducing the minimum inhibitory concentration of methicillin against resistant Staphylococcus aureus 256-fold. Totarol did not inhibit the synthesis of DNA or peptidoglycan in S. aureus, but reduced the respiration rate by 70%. Under potentiation conditions, diterpenes had only a slight effect on the respiration rate, but had a significant effect on expression of PBP 2a. We conclude that the primary staphylococcal target for totarol is the respiratory chain, but that potentiation of methicillin by diterpenes is by interference with PBP 2a expression.
Journal
FEMS Microbiology Letters – Oxford University Press
Published: Oct 17, 1999