Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 7-Day Trial for You or Your Team.

Learn More →

Modulation by glycyrrhetinic acid derivatives of TPA‐induced mouse ear oedema

Modulation by glycyrrhetinic acid derivatives of TPA‐induced mouse ear oedema 1 The anti‐inflammatory effects of glycyrrhetinic acid and its derivatives on TPA (12‐0‐tetradecanoylphorbol‐13‐acetate)‐induced mouse ear oedema were studied. The mechanisms of TPA‐induced ear oedema were first investigated with respect to the chemical mediators. 2 The formation of ear oedema reached a maximum 5 h after TPA application (2 μg per ear) and the prostaglandin E2 (PGE2) production of mouse ear increased with the oedema formation. 3 TPA‐induced ear oedema was prevented by actinomycin D and cycloheximide (0.1 mg per ear, respectively) when applied during 60 min after TPA treatment. 4 Of glycyrrhetinic acid derivatives examined, dihemiphthalate derivatives (IIe, IIe′, IIIa, IIIa′, IVa, IVa′) most strongly inhibited ear oedema on both topical (ID50, 1.6 mg per ear for IIe, 2.0 mg per ear for IIIa and 1.6 mg per ear for IVa) and oral (ID50, 88 mg kg−1 for IIe′, 130 mg kg−1 for IIIa′ and 92 mg kg−1 for IVa′) administration. 5 Glycyrrhetinic acid (Ia) and its derivatives applied 30 min before TPA treatment were much more effective in inhibiting oedema than when applied 30 min after TPA. A dihemiphthalate of triterpenoid compound IVa completely inhibited oedema, even when applied 3 h before TPA treatment. 6 Glycyrrhetinic acid (Ia) and deoxoglycyrrhetol (IIa), the parent compounds, produced little inhibition by oral administration at less than 200 mg kg−1 7 These results suggest that the dihemiphthalate derivatives of triterpenes derived from glycyrrhetinic acid by chemical modification are useful for the treatment of skin inflammation by both topical and oral application. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png British Journal of Pharmacology Wiley

Modulation by glycyrrhetinic acid derivatives of TPA‐induced mouse ear oedema

Download PDF
7 pages

Loading next page...
 
/lp/wiley/modulation-by-glycyrrhetinic-acid-derivatives-of-tpa-induced-mouse-ear-EPb0hH8DzU

References (36)

Publisher
Wiley
Copyright
1989 British Pharmacological Society
ISSN
0007-1188
eISSN
1476-5381
DOI
10.1111/j.1476-5381.1989.tb11801.x
Publisher site
See Article on Publisher Site

Abstract

1 The anti‐inflammatory effects of glycyrrhetinic acid and its derivatives on TPA (12‐0‐tetradecanoylphorbol‐13‐acetate)‐induced mouse ear oedema were studied. The mechanisms of TPA‐induced ear oedema were first investigated with respect to the chemical mediators. 2 The formation of ear oedema reached a maximum 5 h after TPA application (2 μg per ear) and the prostaglandin E2 (PGE2) production of mouse ear increased with the oedema formation. 3 TPA‐induced ear oedema was prevented by actinomycin D and cycloheximide (0.1 mg per ear, respectively) when applied during 60 min after TPA treatment. 4 Of glycyrrhetinic acid derivatives examined, dihemiphthalate derivatives (IIe, IIe′, IIIa, IIIa′, IVa, IVa′) most strongly inhibited ear oedema on both topical (ID50, 1.6 mg per ear for IIe, 2.0 mg per ear for IIIa and 1.6 mg per ear for IVa) and oral (ID50, 88 mg kg−1 for IIe′, 130 mg kg−1 for IIIa′ and 92 mg kg−1 for IVa′) administration. 5 Glycyrrhetinic acid (Ia) and its derivatives applied 30 min before TPA treatment were much more effective in inhibiting oedema than when applied 30 min after TPA. A dihemiphthalate of triterpenoid compound IVa completely inhibited oedema, even when applied 3 h before TPA treatment. 6 Glycyrrhetinic acid (Ia) and deoxoglycyrrhetol (IIa), the parent compounds, produced little inhibition by oral administration at less than 200 mg kg−1 7 These results suggest that the dihemiphthalate derivatives of triterpenes derived from glycyrrhetinic acid by chemical modification are useful for the treatment of skin inflammation by both topical and oral application.

Journal

British Journal of Pharmacology – Wiley

Published: Jan 1, 1989

There are no references for this article.