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Topical Activities of Betamethasone Esters in Man

Topical Activities of Betamethasone Esters in Man Abstract Betamethasone and 23 of its esters and ortho-esters, assayed topically on healthy human subjects, had vasoconstrictor activities ranging from 0.1% to 400% of that of a standard steroid, fluocinolone acetonide. Compared with the standard in ointments, betamethasone 17,21 - methyl - ortho - valerate and betamethasone 17-valerate showed promising activity in the occlusion treatment of psoriasis. It is concluded that, despite its low precision, the vasoconstriction assay is of value for screening potential topically active anti-inflammatory steroids. Vasoconstriction assays should be designed to allow for differences in sensitivity between subjects and between sites of steroid application. References 1. An account of a full clinical trial of betamethasone 17-valerate is being submitted for publication elsewhere. 2. Wells, G. C.: Effect of Hydrocortisone on Standardized Skin Surface Trauma , Brit J Derm 69:11-18, 1957.Crossref 3. Witkowski, J. A., and Kligman, A. M.: Screening Test for Anti-Inflammatory Activity Using Human Skin , J Invest Derm 32:481-483, 1959.Crossref 4. Schlagel, C. A., and Northam, J. I.: Comparative Anti-Inflammatory Efficacy of Topically Applied Steroids on Human Skin , Proc Soc Exp Biol Med 101:629-632, 1959.Crossref 5. Brunner, M. J., and Finkelstein, P.: Laboratory Method for Evaluation of Topical Anti-Inflammatory Agents , AMA Arch Derm 81:453-457, 1960.Crossref 6. McKenzie, A. W., and Stoughton, R. B.: Method for Comparing Percutaneous Absorption of Steroids , Arch Derm 86:608-610, 1962.Crossref 7. McKenzie, A. W.: Percutaneous Absorption of Steroids , Arch Derm 86:611-614, 1962.Crossref 8. Litchfield, J. T., and Wilcoxon, F.: Simplified Method for Evaluating Dose-Effect Experiments , J Pharmacol Exp Ther 96:99-113, 1949. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Dermatology American Medical Association

Topical Activities of Betamethasone Esters in Man

McKENZIE, A. W.; ATKINSON, R. M.
Archives of Dermatology , Volume 89 (5) – May 1, 1964
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References (8)

Publisher
American Medical Association
Copyright
Copyright © 1964 American Medical Association. All Rights Reserved.
ISSN
0003-987X
eISSN
1538-3652
DOI
10.1001/archderm.1964.01590290107016
Publisher site
See Article on Publisher Site

Abstract

Abstract Betamethasone and 23 of its esters and ortho-esters, assayed topically on healthy human subjects, had vasoconstrictor activities ranging from 0.1% to 400% of that of a standard steroid, fluocinolone acetonide. Compared with the standard in ointments, betamethasone 17,21 - methyl - ortho - valerate and betamethasone 17-valerate showed promising activity in the occlusion treatment of psoriasis. It is concluded that, despite its low precision, the vasoconstriction assay is of value for screening potential topically active anti-inflammatory steroids. Vasoconstriction assays should be designed to allow for differences in sensitivity between subjects and between sites of steroid application. References 1. An account of a full clinical trial of betamethasone 17-valerate is being submitted for publication elsewhere. 2. Wells, G. C.: Effect of Hydrocortisone on Standardized Skin Surface Trauma , Brit J Derm 69:11-18, 1957.Crossref 3. Witkowski, J. A., and Kligman, A. M.: Screening Test for Anti-Inflammatory Activity Using Human Skin , J Invest Derm 32:481-483, 1959.Crossref 4. Schlagel, C. A., and Northam, J. I.: Comparative Anti-Inflammatory Efficacy of Topically Applied Steroids on Human Skin , Proc Soc Exp Biol Med 101:629-632, 1959.Crossref 5. Brunner, M. J., and Finkelstein, P.: Laboratory Method for Evaluation of Topical Anti-Inflammatory Agents , AMA Arch Derm 81:453-457, 1960.Crossref 6. McKenzie, A. W., and Stoughton, R. B.: Method for Comparing Percutaneous Absorption of Steroids , Arch Derm 86:608-610, 1962.Crossref 7. McKenzie, A. W.: Percutaneous Absorption of Steroids , Arch Derm 86:611-614, 1962.Crossref 8. Litchfield, J. T., and Wilcoxon, F.: Simplified Method for Evaluating Dose-Effect Experiments , J Pharmacol Exp Ther 96:99-113, 1949.

Journal

Archives of Dermatology – American Medical Association

Published: May 1, 1964

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