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Infection of human tonsil histocultures: A model for HIV pathogenesis

Infection of human tonsil histocultures: A model for HIV pathogenesis © 1995 Nature Publishing Group http://www.nature.com/naturemedicine NEW TECHNOLOGY Infection of human tonsil histocultures: A model for HIV pathogenesis SVETLANA GLUSHAKOVA, BORIS BAIBAKOV, LEONID B. MARGOLIS & jOSHUA ZIMMERBERG Laboratory of Theoretical and Physical Biology, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA Correspondence should be addressed to L.B.M. The critical events in the progression of tropism and phenotype and allows dis­ well-defined germinal centers formed by AIDS occur in human lymphoid tissue'. semination of virus throughout the B cells with T cells concentrated around It is within tissues that the entire system tissue, viral release into the surrounding them. Numerous macrophages were of cell-cell interactions mediating im­ fluid and depletion of CD4· cells. The concentrated in germinal centres and mune function progressively deteriorates method is therefore suitable for a scattered around. Extended networks of and ultimately collapses'. Primary cul­ wide range of HIV research and clinical follicular dendritic cells were found in­ tures and cocultures of isolated cells applications. side germinal centres by 3-D reconstruc­ cannot mimic the full cellular repertoire tion of confocal optical sections of within lymph tissue, nor their functional Histoculture architecture histocultured blocks immunostained relationship to lymphoid http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Nature Medicine Springer Journals

Infection of human tonsil histocultures: A model for HIV pathogenesis

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References (13)

Publisher
Springer Journals
Copyright
Copyright © 1995 by Nature Publishing Group
Subject
Biomedicine; Biomedicine, general; Cancer Research; Metabolic Diseases; Infectious Diseases; Molecular Medicine; Neurosciences
ISSN
1078-8956
eISSN
1546-170X
DOI
10.1038/nm1295-1320
Publisher site
See Article on Publisher Site

Abstract

© 1995 Nature Publishing Group http://www.nature.com/naturemedicine NEW TECHNOLOGY Infection of human tonsil histocultures: A model for HIV pathogenesis SVETLANA GLUSHAKOVA, BORIS BAIBAKOV, LEONID B. MARGOLIS & jOSHUA ZIMMERBERG Laboratory of Theoretical and Physical Biology, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA Correspondence should be addressed to L.B.M. The critical events in the progression of tropism and phenotype and allows dis­ well-defined germinal centers formed by AIDS occur in human lymphoid tissue'. semination of virus throughout the B cells with T cells concentrated around It is within tissues that the entire system tissue, viral release into the surrounding them. Numerous macrophages were of cell-cell interactions mediating im­ fluid and depletion of CD4· cells. The concentrated in germinal centres and mune function progressively deteriorates method is therefore suitable for a scattered around. Extended networks of and ultimately collapses'. Primary cul­ wide range of HIV research and clinical follicular dendritic cells were found in­ tures and cocultures of isolated cells applications. side germinal centres by 3-D reconstruc­ cannot mimic the full cellular repertoire tion of confocal optical sections of within lymph tissue, nor their functional Histoculture architecture histocultured blocks immunostained relationship to lymphoid

Journal

Nature Medicine – Springer Journals

Published: Dec 1, 1995

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