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- Publisher
- SAGE
- Copyright
- © International & American Associations for Dental Research 2020
- ISSN
- 0022-0345
- eISSN
- 1544-0591
- DOI
- 10.1177/0022034520932834
- Publisher site
- See Article on Publisher Site
Abstract
Stem cells play a critical role in bone regeneration. Multiple populations of skeletal stem cells have been identified in long bone, while their identity and functions in alveolar bone remain unclear. Here, we identified a quiescent leptin receptor–expressing (LepR+) cell population that contributed to intramembranous bone formation. Interestingly, these LepR+ cells became activated in response to tooth extraction and generated the majority of the newly formed bone in extraction sockets. In addition, genetic ablation of LepR+ cells attenuated extraction socket healing. The parabiosis experiments revealed that the LepR+ cells in the healing sockets were derived from resident tissue rather than peripheral blood circulation. Further studies on the mechanism suggested that these LepR+ cells were responsive to parathyroid hormone/parathyroid hormone 1 receptor (PTH/PTH1R) signaling. Collectively, we demonstrate that LepR+ cells, a postnatal skeletal stem cell population, are essential for alveolar bone regeneration of extraction sockets.
Journal
Journal of Dental Research: Featuring Critical Reviews in Oral Biology & Medicine – SAGE
Published: Oct 1, 2020