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A comprehensive synthetic genetic interaction network governing yeast histone acetylation and deacetylation

A comprehensive synthetic genetic interaction network governing yeast histone acetylation and... Downloaded from genesdev.cshlp.org on November 26, 2021 - Published by Cold Spring Harbor Laboratory Press A comprehensive synthetic genetic interaction network governing yeast histone acetylation and deacetylation 1,2 1,3 1,4 1,2,6 1,2 5 Yu-yi Lin, Yan Qi, Jin-ying Lu, Xuewen Pan, Daniel S. Yuan, Yingming Zhao, 1,3 1,2,7 Joel S. Bader, and Jef D. Boeke High-Throughput Biology Center, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA; Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, 3 4 USA; Department of Biomedical Engineering, Johns Hopkins University, Baltimore, Maryland 21218, USA; Department of Pharmacology and Molecular Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA; Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA Histone acetylation and deacetylation are among the principal mechanisms by which chromatin is regulated during transcription, DNA silencing, and DNA repair. We analyzed patterns of genetic interactions uncovered during comprehensive genome-wide analyses in yeast to probe how histone acetyltransferase (HAT) and histone deacetylase (HDAC) protein complexes interact. The genetic interaction data unveil an underappreciated role of HDACs in maintaining cellular viability, and led us to show that deacetylation of the histone variant Htz1p http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Genes & Development Unpaywall

A comprehensive synthetic genetic interaction network governing yeast histone acetylation and deacetylation

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Unpaywall
ISSN
0890-9369
DOI
10.1101/gad.1679508
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Abstract

Downloaded from genesdev.cshlp.org on November 26, 2021 - Published by Cold Spring Harbor Laboratory Press A comprehensive synthetic genetic interaction network governing yeast histone acetylation and deacetylation 1,2 1,3 1,4 1,2,6 1,2 5 Yu-yi Lin, Yan Qi, Jin-ying Lu, Xuewen Pan, Daniel S. Yuan, Yingming Zhao, 1,3 1,2,7 Joel S. Bader, and Jef D. Boeke High-Throughput Biology Center, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA; Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, 3 4 USA; Department of Biomedical Engineering, Johns Hopkins University, Baltimore, Maryland 21218, USA; Department of Pharmacology and Molecular Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA; Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA Histone acetylation and deacetylation are among the principal mechanisms by which chromatin is regulated during transcription, DNA silencing, and DNA repair. We analyzed patterns of genetic interactions uncovered during comprehensive genome-wide analyses in yeast to probe how histone acetyltransferase (HAT) and histone deacetylase (HDAC) protein complexes interact. The genetic interaction data unveil an underappreciated role of HDACs in maintaining cellular viability, and led us to show that deacetylation of the histone variant Htz1p

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Genes & Development – Unpaywall

Published: Aug 1, 2008

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