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- Publisher
- Wiley
- Copyright
- Copyright © 1980 American College of Rheumatology
- ISSN
- 0004-3591
- eISSN
- 1529-0131
- DOI
- 10.1002/art.1780231107
- Publisher site
- See Article on Publisher Site
Abstract
A search for anti‐Ro or anti‐nRNP antibodies by precipitin analysis among a population of 64 patients with systemic lupus erythematosus (SLE) or mixed connective tissue disease was undertaken. The 25% of SLE patients with anti‐Ro did not have any distinct clinical features, compared to patients without anti‐Ro or to anti‐nRNP patients with SLE or mixed connective tissue disease. However, these patients did have a significantly greater frequency of rheumatoid factor (80%). Most importantly however, patients with anti‐Ro had a significantly increased frequency of HLA‐B8 (81%) and HLA‐DRw3 (100%) compared to patients with anti‐nRNP (B8—29%; DRw3—33%) or SLE patients without such antibodies (B8—41%; DRw3—25%). These data suggest the existence of a specific immune response gene for Ro close to the D region of the major histocompatibility complex.
Journal
Arthritis & Rheumatism – Wiley
Published: Nov 1, 1980