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Age‐related expression patterns of Bag‐1 and Bcl‐2 in growth plate and articular chondrocytes

Age‐related expression patterns of Bag‐1 and Bcl‐2 in growth plate and articular chondrocytes Aging cartilage displays increased chondrocyte apoptosis and decreased responsiveness of chondrocytes to growth factors. The molecular mechanisms responsible for these changes have not been identified. Bag‐1 is a Bcl‐2‐binding protein that promotes cell survival, interacts with a diverse group of cellular proteins, and may integrate multiple pathways involved in controlling cell survival, growth, and phenotype. Bcl‐2 is important for maintaining chondrocyte phenotype and delaying terminal differentiation and apoptosis of chondrocytes. Comparatively little is known about the role of Bag‐1 in cartilage. Here we show that both growth plate and articular chondrocytes in the mouse express the Bag‐1 protein. In the growth plate, Bag‐1 expression is prominent in the late proliferative and prehypertrophic chondrocytes, displaying a pattern similar to what has been reported for Bcl‐2. Further, the expression of both Bcl‐2 and Bag‐1 declines with age in the articular cartilage. Growth assays demonstrate that knocking down Bag‐1 expression causes a decrease in growth rate. These results suggest that Bag‐1 is involved in the regulation of chondrocyte phenotype and cartilage aging. © 2004 Wiley‐Liss, Inc. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology Wiley

Age‐related expression patterns of Bag‐1 and Bcl‐2 in growth plate and articular chondrocytes

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References (44)

Publisher
Wiley
Copyright
Copyright © 2004 Wiley Subscription Services, Inc., A Wiley Company
ISSN
1932-8486
eISSN
1932-8494
DOI
10.1002/ar.a.20063
Publisher site
See Article on Publisher Site

Abstract

Aging cartilage displays increased chondrocyte apoptosis and decreased responsiveness of chondrocytes to growth factors. The molecular mechanisms responsible for these changes have not been identified. Bag‐1 is a Bcl‐2‐binding protein that promotes cell survival, interacts with a diverse group of cellular proteins, and may integrate multiple pathways involved in controlling cell survival, growth, and phenotype. Bcl‐2 is important for maintaining chondrocyte phenotype and delaying terminal differentiation and apoptosis of chondrocytes. Comparatively little is known about the role of Bag‐1 in cartilage. Here we show that both growth plate and articular chondrocytes in the mouse express the Bag‐1 protein. In the growth plate, Bag‐1 expression is prominent in the late proliferative and prehypertrophic chondrocytes, displaying a pattern similar to what has been reported for Bcl‐2. Further, the expression of both Bcl‐2 and Bag‐1 declines with age in the articular cartilage. Growth assays demonstrate that knocking down Bag‐1 expression causes a decrease in growth rate. These results suggest that Bag‐1 is involved in the regulation of chondrocyte phenotype and cartilage aging. © 2004 Wiley‐Liss, Inc.

Journal

The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology – Wiley

Published: Aug 1, 2004

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