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References (23)
-
D. Cressman, L. Greenbaum, B. Haber, R. Taub (1994)
Rapid activation of post-hepatectomy factor/nuclear factor kappa B in hepatocytes, a primary response in the regenerating liver.The Journal of biological chemistry, 269 48
-
H. Liou, William Sha, M. Scott, David Baltimore (1994)
Sequential induction of NF-kappa B/Rel family proteins during B-cell terminal differentiation.Molecular and cellular biology, 14 8
-
Robert Montgomery, M. Dallman (1991)
Analysis of cytokine gene expression during fetal thymic ontogeny using the polymerase chain reaction.Journal of immunology, 147 2
-
A. Wyllie, R. Morris, Ashlyn Smith, D. Dunlop (1984)
Chromatin cleavage in apoptosis: Association with condensed chromatin morphology and dependence on macromolecular synthesisThe Journal of Pathology, 142
-
B. Stein, A. Baldwin, D. Ballard, W. Greene, P. Angel, P. Herrlich (1993)
Cross‐coupling of the NF‐kappa B p65 and Fos/Jun transcription factors produces potentiated biological function.The EMBO Journal, 12
-
and Baeuerle, T. Henkel (1994)
Function and activation of NF-kappa B in the immune system.Annual review of immunology, 12
-
L. Burkly, C. Hession, L. Ogata, C. Reilly, Lori Marconl, D. Olson, R. Tizard, Richard Gate, D. Lo (1995)
Expression of relB is required for the development of thymic medulla and dendritic cellsNature, 373
-
V. Tybulewicz, Camila Crawford, Peter Jackson, R. Bronson, R. Mulligan (1991)
Neonatal lethality and lymphopenia in mice with a homozygous disruption of the c-abl proto-oncogeneCell, 65
-
F. Weih, D. Carrasco, S. Durham, D. Barton, C. Rizzo, R. Ryseck, S. Lira, R. Bravo (1995)
Multiorgan inflammation and hematopoietic abnormalities in mice with a targeted disruption of RelB, a member of the NF-κB/Rel familyCell, 80
-
S. Haskill, A. Beg, S. Tompkins, John Morris, A. Yurochko, A. Sampson‐Johannes, K. Mondal, P. Ralph, A. Baldwin (1991)
Characterization of an immediate-early gene induced in adherent monocytes that encodes IκB-like activityCell, 65
-
D. Thanos, T. Maniatis (1995)
NF-κB: A lesson in family valuesCell, 80
-
Corinne Abbadie, Corinne Abbadie, N. Kabrun, F. Bouali, J. Šmardová, D. Stéhelin, B. Vandenbunder, P. Enrietto (1993)
High levels of c-rel expression are associated with programmed cell death in the developing avian embryo and in bone marrow cells in vitroCell, 75
-
Nancy Rice, M. MacKichan, Alain Israël (1992)
The precursor of NF-κB p50 has IκB-like functionsCell, 71
-
A. Plump, Jonathan Smith, T. Hayek, K. Aalto-setälä, A. Walsh, J. Verstuyft, E. Rubin, J. Breslow (1992)
Severe hypercholesterolemia and atherosclerosis in apolipoprotein E-deficient mice created by homologous recombination in ES cellsCell, 71
-
A. Beg, A. Baldwin (1993)
The I kappa B proteins: multifunctional regulators of Rel/NF-kappa B transcription factors.Genes & development, 7 11
-
W. Sha, H. Liou, E. Tuomanen, D. Baltimore (1995)
Targeted disruption of the p50 subunit of NF-κB leads to multifocal defects in immune responsesCell, 80
-
A. Beg, T. Finco, P. Nantermet, A. Baldwin (1993)
Tumor necrosis factor and interleukin-1 lead to phosphorylation and loss of I kappa B alpha: a mechanism for NF-kappa B activationMolecular and Cellular Biology, 13
-
F. Hilberg, A. Aguzzi, N. Howells, E. Wagner (1993)
c-Jun is essential for normal mouse development and hepatogenesisNature, 365
-
James Thompson, R. Phillips, H. Erdjument-Bromage, P. Tempst, S. Ghosh (1995)
IκB-β regulates the persistent response in a biphasic activation of NF-κBCell, 80
-
G. Nolan, S. Ghosh, H. Liou, P. Tempst, D. Baltimore (1991)
DNA binding and IκB inhibition of the cloned p65 subunit of NF-κB, a rel-related polypeptideCell, 64
-
M. Grilli, J. Chiu, M. Lenardo (1993)
NF-kappa B and Rel: participants in a multiform transcriptional regulatory system.International review of cytology, 143
-
Yael Gavrieli, Y. Sherman, S. Ben‐Sasson (1992)
Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentationThe Journal of Cell Biology, 119
-
M. Scott, T. Fujita, H. Liou, G. Nolan, D. Baltimore (1993)
The p65 subunit of NF-kappa B regulates I kappa B by two distinct mechanisms.Genes & development, 7 7A
- Publisher
- Springer Journals
- Copyright
- Copyright © 1995 by Nature Publishing Group
- Subject
- Science, Humanities and Social Sciences, multidisciplinary; Science, Humanities and Social Sciences, multidisciplinary; Science, multidisciplinary
- ISSN
- 0028-0836
- eISSN
- 1476-4687
- DOI
- 10.1038/376167a0
- Publisher site
- See Article on Publisher Site
Abstract
NF-κB, which consists of two polypeptides, p50 (Mr 50K) and p65/RelA (Mr 65K), is thought to be a key regulator of genes involved in responses to infection, inflammation and stress1. Indeed, although developmentally normal, mice deficient in p50 display functional defects in immune responses2. Here we describe the generation of mice deficient in the RelA subunit of NF-κB. Disruption of the relA locus leads to embryonic lethality at 15–16 days of gestation, concomitant with a massive degeneration of the liver by programmed cell death or apoptosis. Embryonic fibroblasts from RelA-deficient mice are defective in the tumour necrosis factor (TNF)-mediated induction of messenger RNAs for IκBα and granulocyte/macrophage colony stimulating factor (GM-CSF), although basal levels of these transcripts are unaltered. These results indicate that RelA controls inducible, but not basal, transcription in NF-κB-regulated pathways.
Journal
Nature – Springer Journals
Published: Jul 13, 1995