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- Publisher
- Springer Journals
- Copyright
- Copyright © 2010 by Nature Publishing Group, a division of Macmillan Publishers Limited. All Rights Reserved.
- Subject
- Science, Humanities and Social Sciences, multidisciplinary; Science, Humanities and Social Sciences, multidisciplinary; Science, multidisciplinary
- ISSN
- 0028-0836
- eISSN
- 1476-4687
- DOI
- 10.1038/nature09421
- Publisher site
- See Article on Publisher Site
Abstract
Inflammation is known to cause oxidative stress and the growth of new blood vessels, and now a molecular mechanism linking these processes has been found. Oxidized products of lipid oxidation — (carboxy alkyl)pyrrole protein adducts — are generated during inflammation and wound healing. These products are shown to act as endogenous agonists for Toll-like receptor 2 (TLR2), which stimulates blood vessel growth through a mechanism that is independent of vascular endothelial growth factor. This work establishes a new function for TLR2 as a sensor of oxidation-associated molecular patterns, providing a link connecting inflammation, oxidative stress, innate immunity and angiogenesis.
Journal
Nature – Springer Journals
Published: Oct 3, 2010