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Assessment of Neutrophil/Lymphocyte Ratio in Patients with Age-related Macular Degeneration

Assessment of Neutrophil/Lymphocyte Ratio in Patients with Age-related Macular Degeneration AbstractPurpose: To investigate the neutrophil/lymphocyte ratio (NLR) as an indicator of inflammation in patients with age-related macular degeneration (AMD).Methods: Patients were evaluated by a review of records. The study included 81 patients with dry AMD (group 1), 84 patients with wet AMD (group 2), and 80 healthy age- and sex-matched controls (group 3). The NLR of the patients was obtained from the hospital laboratory archive and was measured by dividing the neutrophil count by the lymphocyte count.Results: A significant difference was found in NLR values between groups 1 and 2 (p = 0.017), groups 2 and 3 (p < 0.001), and groups 1 and 3 (p < 0.001). In correlation analyses, NLR was correlated positively with age (r = 0.22, p <0.001) and disease severity (r = 0.40, p < 0.001).Conclusions: Patients with AMD have higher NLR compared with controls, and NLR correlates with disease severity. NLR may be used as a biomarker of inflammation in AMD. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Ocular Immunology & Inflammation Taylor & Francis

Assessment of Neutrophil/Lymphocyte Ratio in Patients with Age-related Macular Degeneration

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References (44)

Publisher
Taylor & Francis
Copyright
© 2015 Taylor & Francis Group, LLC
ISSN
1744-5078
eISSN
0927-3948
DOI
10.3109/09273948.2014.921715
Publisher site
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Abstract

AbstractPurpose: To investigate the neutrophil/lymphocyte ratio (NLR) as an indicator of inflammation in patients with age-related macular degeneration (AMD).Methods: Patients were evaluated by a review of records. The study included 81 patients with dry AMD (group 1), 84 patients with wet AMD (group 2), and 80 healthy age- and sex-matched controls (group 3). The NLR of the patients was obtained from the hospital laboratory archive and was measured by dividing the neutrophil count by the lymphocyte count.Results: A significant difference was found in NLR values between groups 1 and 2 (p = 0.017), groups 2 and 3 (p < 0.001), and groups 1 and 3 (p < 0.001). In correlation analyses, NLR was correlated positively with age (r = 0.22, p <0.001) and disease severity (r = 0.40, p < 0.001).Conclusions: Patients with AMD have higher NLR compared with controls, and NLR correlates with disease severity. NLR may be used as a biomarker of inflammation in AMD.

Journal

Ocular Immunology & Inflammation – Taylor & Francis

Published: Jul 4, 2015

Keywords: Age-related macular degeneration; blindness; inflammation; neutrophil/lymphocyte ratio; retinal drusen

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