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R. Benetti, Marta García‐Cao, M. Blasco (2007)
Telomere length regulates the epigenetic status of mammalian telomeres and subtelomeresNature Genetics, 39
N. Dimitrova, T. Lange (2006)
MDC1 accelerates nonhomologous end-joining of dysfunctional telomeres.Genes & development, 20 23
H. Takai, A. Smogorzewska, T. Lange (2003)
DNA Damage Foci at Dysfunctional TelomeresCurrent Biology, 13
C. Sherr, R. DePinho (2000)
Cellular Senescence Minireview Mitotic Clock or Culture Shock?Cell, 102
F. Takeuchi, F. Hanaoka, M. Goto, M. Yamada, T. Miyamoto (1982)
Prolongation of S phase and whole cell cycle in Werner's syndrome fibroblastsExperimental Gerontology, 17
R. Verdun, J. Karlseder (2007)
Replication and protection of telomeresNature, 447
Joseph Landry, A. Sutton, S. Tafrov, Ryan Heller, J. Stebbins, L. Pillus, R. Sternglanz (2000)
The silencing protein SIR2 and its homologs are NAD-dependent protein deacetylases.Proceedings of the National Academy of Sciences of the United States of America, 97 11
K. Ariyoshi, Keiji Suzuki, M. Goto, M. Watanabe, S. Kodama (2007)
Increased chromosome instability and accumulation of DNA double-strand breaks in Werner syndrome cells.Journal of radiation research, 48 3
M. Overbeek, T. Lange (2006)
Apollo, an Artemis-Related Nuclease, Interacts with TRF2 and Protects Human Telomeres in S PhaseCurrent Biology, 16
A. Multani, Sandy Chang (2007)
WRN at telomeres: implications for aging and cancerJournal of Cell Science, 120
P. Laud, A. Multani, S. Bailey, Ling-Chia Wu, Jin Ma, C. Kingsley, M. Lebel, S. Pathak, R. DePinho, Sandy Chang (2005)
Elevated telomere-telomere recombination in WRN-deficient, telomere dysfunctional cells promotes escape from senescence and engagement of the ALT pathway.Genes & development, 19 21
W. Cheng, Meltem Muftuoglu, V. Bohr (2007)
Werner syndrome protein: Functions in the response to DNA damage and replication stress in S-phaseExperimental Gerontology, 42
U. Herbig, Wendy Jobling, B. Chen, David Chen, J. Sedivy (2004)
Telomere shortening triggers senescence of human cells through a pathway involving ATM, p53, and p21(CIP1), but not p16(INK4a).Molecular cell, 14 4
M. Poot, H. Hoehn, T. Rünger, G. Martin, G. Martin (1992)
Impaired S-phase transit of Werner syndrome cells expressed in lymphoblastoid cell lines.Experimental cell research, 202 2
Katrin Chua, R. Mostoslavsky, D. Lombard, W. Pang, Shinichi Saito, S. Franco, Dhruv Kaushal, Hwei-Ling Cheng, Miriam Fischer, N. Stokes, Michael Murphy, E. Appella, F. Alt (2005)
Mammalian SIRT1 limits replicative life span in response to chronic genotoxic stress.Cell metabolism, 2 1
B. Steensel, A. Smogorzewska, T. Lange (1998)
TRF2 Protects Human Telomeres from End-to-End FusionsCell, 92
Laure Crabbe, R. Verdun, C. Haggblom, J. Karlseder (2004)
Defective Telomere Lagging Strand Synthesis in Cells Lacking WRN Helicase ActivityScience, 306
Henrik Tommerup, Athanasios Dousmanis, Titia, de, Lange (1994)
Unusual chromatin in human telomeresMolecular and Cellular Biology, 14
S. Imai, Christopher Armstrong, M. Kaeberlein, L. Guarente (2000)
Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylaseNature, 403
Sandy Chang, A. Multani, Noelia Cabrera, M. Naylor, P. Laud, D. Lombard, S. Pathak, L. Guarente, R. DePinho (2004)
Essential role of limiting telomeres in the pathogenesis of Werner syndromeNature Genetics, 36
F. Fagagna, P. Reaper, Lorena Clay-Farrace, H. Fiegler, P. Carr, T. Zglinicki, G. Saretzki, N. Carter, S. Jackson (2003)
A DNA damage checkpoint response in telomere-initiated senescenceNature, 426
P. Opresko, M. Otterlei, J. Graakjaer, P. Bruheim, Lale Dawut, S. Kolvraa, A. May, M. Seidman, Vilhem Bohr (2004)
The Werner syndrome helicase and exonuclease cooperate to resolve telomeric D loops in a manner regulated by TRF1 and TRF2.Molecular cell, 14 6
H. Padilla-Nash, K. Heselmeyer-Haddad, D. Wangsa, Hongen Zhang, B. Ghadimi, M. Macville, M. Augustus, E. Schröck, E. Hilgenfeld, T. Ried (2001)
Jumping translocations are common in solid tumor cell lines and result in recurrent fusions of whole chromosome armsGenes, 30
D. Loayza, T. Lange (2003)
POT1 as a terminal transducer of TRF1 telomere length controlNature, 423
C. Sherr, R. DePinho (2000)
Cellular senescence: mitotic clock or culture shock?Cell, 102 4
Laure Crabbe, A. Jauch, C. Naeger, H. Holtgreve‐Grez, J. Karlseder (2007)
Telomere dysfunction as a cause of genomic instability in Werner syndromeProceedings of the National Academy of Sciences, 104
J. Campisi (2005)
Senescent Cells, Tumor Suppression, and Organismal Aging: Good Citizens, Bad NeighborsCell, 120
M. Blasco (2007)
The epigenetic regulation of mammalian telomeresNature Reviews Genetics, 8
F. Wyllie, C. Jones, J. Skinner, M. Haughton, C. Wallis, D. Wynford‐Thomas, R. Faragher, D. Kipling (2000)
Telomerase prevents the accelerated cell ageing of Werner syndrome fibroblastsNature Genetics, 24
E. Michishita, Jean Park, Jenna Burneskis, J. Barrett, I. Horikawa (2005)
Evolutionarily conserved and nonconserved cellular localizations and functions of human SIRT proteins.Molecular biology of the cell, 16 10
E. Schröck, S. Manoir, T. Veldman, B. Schoell, J. Wienberg, M. Ferguson-Smith, Yihang Ning, D. Ledbetter, I. Bar-Am, D. Soenksen, Y. Garini, T. Ried (1996)
Multicolor Spectral Karyotyping of Human ChromosomesScience, 273
R. Mostoslavsky, Katrin Chua, D. Lombard, Wendy Pang, Miriam Fischer, L. Gellon, Pingfang Liu, G. Mostoslavsky, S. Franco, Michael Murphy, Kevin Mills, Parin Patel, Joyce Hsu, Andrew Hong, E. Ford, Hwei-Ling Cheng, Caitlin Kennedy, Nomeli Nunez, R. Bronson, D. Frendewey, W. Auerbach, D. Valenzuela, M. Karow, M. Hottiger, S. Hursting, J. Barrett, L. Guarente, R. Mulligan, B. Demple, G. Yancopoulos, Frederick Alt (2006)
Genomic Instability and Aging-like Phenotype in the Absence of Mammalian SIRT6Cell, 124
Goberdhan Dimri, X. Lee, G. Basile, M. Acosta, G. Scott, C. Roskelley, E. Medrano, M. Linskens, I. Rubelj, O. Pereira-smith (1995)
A biomarker that identifies senescent human cells in culture and in aging skin in vivo.Proceedings of the National Academy of Sciences of the United States of America, 92 20
The Sir2 family member SIRT6 is an NAD-dependent, histone H3 lysine 9 deacetylase enzyme that modulates telomeric chromatin and is required for stable association of WRN, the factor that is mutated in Werner Syndrome.
Nature – Springer Journals
Published: Mar 12, 2008
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