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- Publisher
- Springer Journals
- Copyright
- Copyright © 2009 by Macmillan Publishers Limited. All rights reserved
- Subject
- Science, Humanities and Social Sciences, multidisciplinary; Science, Humanities and Social Sciences, multidisciplinary; Science, multidisciplinary
- ISSN
- 0028-0836
- eISSN
- 1476-4687
- DOI
- 10.1038/nature08191
- Publisher site
- See Article on Publisher Site
Abstract
Recent studies in mice identified multipotent embryonic ISL1+ (Islet 1 expressing) progenitor cells as capable of contributing to all of the major cell types in the heart. Human cardiogenesis is thought to involve more divergent pathways. Now a diverse set of human fetal ISL1+ cardiovascular progenitor populations with multipotent capability has been identified in the right atrium and outflow tract of the developing human heart. Transgenic and gene-targeting techniques applied to human embryonic stem cell lines show that purified populations of these primordial progenitors are capable of self-renewal and expansion prior to differentiation into the three major cell types in the heart — the cardiomyocytes, smooth muscle and endothelia. This has relevance for the production of human models for cardiovascular disease and potentially for human regenerative medicine.
Journal
Nature – Springer Journals
Published: Jul 2, 2009