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- Publisher
- Wiley
- Copyright
- Copyright © 1993 Wiley‐Liss, Inc., A Wiley Company
- ISSN
- 1045-2257
- eISSN
- 1098-2264
- DOI
- 10.1002/gcc.2870080107
- Publisher site
- See Article on Publisher Site
Abstract
Recent evidence suggests that the human interferon‐inducible double‐stranded RNA‐dependent protein kinase may function as a tumor suppressor. Here we describe the mapping of the gene for this kinase to chromosome region 2p21‐22 by fluorescence in situ hybridization. A combined analysis of cytogenetic data from a series of 341 patients with hematologic disorders that exhibited cytogenetic abnormalities and from published reports indicates that abnormalities involving 2p21‐22 occur nonrandomly and are observed among patients with acute myelogenous leukemia, raising the possibility of a role for this protein kinase in leukemogenesis. © 1993 Wiley‐Liss, Inc.
Journal
Genes, Chromosomes and Cancer – Wiley
Published: Sep 1, 1993