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- Publisher
- Oxford University Press
- Copyright
- © Oxford University Press
- ISSN
- 0268-1161
- eISSN
- 1460-2350
- DOI
- 10.1093/oxfordjournals.humrep.a138327
- Publisher site
- See Article on Publisher Site
Abstract
Abstract To investigate the role(s) of interleukin-1β (IL-1β) in human ovarian function, we measured the concentrations of IL–1β, prostaglandins (PGs) and steroids in follicular fluid of 90 stimulated ovaries, with reference to oocyte maturation. Concentrations of IL-1β were significantly higher in the follicles from which mature oocytes were recovered than in follicles from which oocytes could not be recovered (P < 0.05). IL-1β concentrations also increased in association with oocyte maturation. Positive significant correlations were seen between IL-1β and prostaglandin E2 (PGE2) (r = 0.47, P < 0.001), and between IL-1β and prostaglandin F2α (PGF2α) (r = 0.22, P < 0.05) in pre-ovulatory follicular fluid, but not between IL–1β and oestradiol, or between IL-1β and oestradiol, or between IL-1β and progesterone. 0Follicular fluid IL-1β might contribute to prostaglandin-induced oocyte maturation and ovulation. follicular fluid, IL-1β, oocyte maturation, ovulation, PGE2, PGF2α This content is only available as a PDF. © Oxford University Press
Journal
Human Reproduction – Oxford University Press
Published: Jan 1, 1994