Access the full text.
Sign up today, get DeepDyve free for 14 days.
Loading next page...
/lp/springer-journals/common-variants-in-wfs1-confer-risk-of-type-2-diabetes-BPWfo0eQap
References (15)
-
Umut Özcan, E. Yilmaz, Lale Özcan, M. Furuhashi, Éric Vaillancourt, R. Smith, Cem Görgün, G. Hotamışlıgil (2006)
Chemical Chaperones Reduce ER Stress and Restore Glucose Homeostasis in a Mouse Model of Type 2 DiabetesScience, 313
-
(2000)
Association between SNPs located in WFS1 and risk of type 2 diabetes: replication studies and pooled analysis SNP Odds ratio (95% c.i.) P value ADDITION study -
A. Riggs, E. Bernal-Mizrachi, M. Ohsugi, J. Wasson, S. Fátrai, C. Welling, J. Murray, R. Schmidt, P. Herrera, M. Permutt (2005)
Mice conditionally lacking the Wolfram gene in pancreatic islet beta cells exhibit diabetes as a result of enhanced endoplasmic reticulum stress and apoptosisDiabetologia, 48
-
E. Nielsen, L. Hansen, B. Carstensen, S. Echwald, T. Drivsholm, C. Glümer, B. Thorsteinsson, K. Borch-Johnsen, T. Hansen, O. Pedersen (2003)
The E23K variant of Kir6.2 associates with impaired post-OGTT serum insulin response and increased risk of type 2 diabetes.Diabetes, 52 2
-
H. Inoue, Y. Tanizawa, J. Wasson, P. Behn, K. Kalidas, E. Bernal-Mizrachi, M. Mueckler, Helen Marshall, H. Donis-Keller, P. Crock, D. Rogers, M. Mikuni, H. Kumashiro, K. Higashi, G. Sobue, Y. Oka, M. Permutt (1998)
A gene encoding a transmembrane protein is mutated in patients with diabetes mellitus and optic atrophy (Wolfram syndrome)Nature Genetics, 20
-
D. Altshuler, J. Hirschhorn, M. Klannemark, C. Lindgren, M. Vohl, J. Nemesh, C. Lane, S. Schaffner, S. Bolk, C. Brewer, T. Tuomi, D. Gaudet, T. Hudson, M. Daly, L. Groop, E. Lander (2000)
The common PPARγ Pro12Ala polymorphism is associated with decreased risk of type 2 diabetesNature Genetics, 26
-
K. Silander, K. Mohlke, L. Scott, E. Peck, Pablo Hollstein, Andrew Skol, A. Jackson, P. Deloukas, S. Hunt, G. Stavrides, P. Chines, M. Erdos, Narisu Narisu, K. Conneely, Chun Li, T. Fingerlin, S. Dhanjal, T. Valle, R. Bergman, J. Tuomilehto, R. Watanabe, M. Boehnke, F. Collins (2004)
Genetic variation near the hepatocyte nuclear factor-4 alpha gene predicts susceptibility to type 2 diabetes.Diabetes, 53 4
-
T. Strom, K. Hörtnagel, S. Hofmann, F. Gekeler, C. Scharfe, W. Rabl, K. Gerbitz, T. Meitinger (1998)
Diabetes insipidus, diabetes mellitus, optic atrophy and deafness (DIDMOAD) caused by mutations in a novel gene (wolframin) coding for a predicted transmembrane protein.Human molecular genetics, 7 13
-
Takahiro Yamada, H. Ishihara, Akira Tamura, Rui Takahashi, Suguru Yamaguchi, Daisuke Takei, A. Tokita, C. Satake, F. Tashiro, H. Katagiri, H. Aburatani, J. Miyazaki, Y. Oka (2006)
WFS1-deficiency increases endoplasmic reticulum stress, impairs cell cycle progression and triggers the apoptotic pathway specifically in pancreatic beta-cells.Human molecular genetics, 15 10
-
L. Love-Gregory, J. Wasson, Jiyan Ma, Carol Jin, B. Glaser, B. Suarez, M. Permutt, A. Permutt (2004)
A common polymorphism in the upstream promoter region of the hepatocyte nuclear factor-4 alpha gene on chromosome 20q is associated with type 2 diabetes and appears to contribute to the evidence for linkage in an ashkenazi jewish population.Diabetes, 53 4
-
A. Karasik, C. O'Hara, S. Srikanta, M. Swift, S. Soeldner, C. Kahn, R. Herskowitz (1989)
Genetically Programmed Selective Islet β-Cell Loss in Diabetic Subjects With Wolfram's SyndromeDiabetes Care, 12
-
A. Gloyn, M. Weedon, K. Owen, M. Turner, B. Knight, G. Hitman, M. Walker, J. Levy, M. Sampson, S. Halford, M. McCarthy, A. Hattersley, T. Frayling (2003)
Large-scale association studies of variants in genes encoding the pancreatic beta-cell KATP channel subunits Kir6.2 (KCNJ11) and SUR1 (ABCC8) confirm that the KCNJ11 E23K variant is associated with type 2 diabetes.Diabetes, 52 2
-
H. Ishihara, S. Takeda, Akira Tamura, Rui Takahashi, Suguru Yamaguchi, Daisuke Takei, Takahiro Yamada, H. Inoue, H. Soga, H. Katagiri, Y. Tanizawa, Y. Oka (2004)
Disruption of the WFS1 gene in mice causes progressive beta-cell loss and impaired stimulus-secretion coupling in insulin secretion.Human molecular genetics, 13 11
-
S. Grant, G. Thorleifsson, I. Reynisdottir, R. Benediktsson, A. Manolescu, J. Sainz, Agnar Helgason, H. Stefánsson, V. Emilsson, A. Helgadóttir, U. Styrkársdóttir, K. Magnússon, G. Walters, E. Pálsdóttir, T. Jonsdottir, T. Gudmundsdóttir, Arnaldur Gylfason, Jona Saemundsdottir, R. Wilensky, M. Reilly, D. Rader, Y. Bagger, C. Christiansen, V. Gudnason, Gunnar Sigurdsson, U. Thorsteinsdóttir, J. Gulcher, A. Kong, K. Stefánsson (2006)
Variant of transcription factor 7-like 2 (TCF7L2) gene confers risk of type 2 diabetesNature Genetics, 38
-
J. Minton, A. Hattersley, K. Owen, M. McCarthy, M. Walker, F. Latif, T. Barrett, T. Frayling (2002)
Association studies of genetic variation in the WFS1 gene and type 2 diabetes in U.K. populations.Diabetes, 51 4
- Publisher
- Springer Journals
- Copyright
- Copyright © 2007 by Nature Publishing Group
- Subject
- Biomedicine; Biomedicine, general; Human Genetics; Cancer Research; Agriculture; Gene Function; Animal Genetics and Genomics
- ISSN
- 1061-4036
- eISSN
- 1546-1718
- DOI
- 10.1038/ng2067
- Publisher site
- See Article on Publisher Site
Abstract
We studied genes involved in pancreatic β cell function and survival, identifying associations between SNPs in WFS1 and diabetes risk in UK populations that we replicated in an Ashkenazi population and in additional UK studies. In a pooled analysis comprising 9,533 cases and 11,389 controls, SNPs in WFS1 were strongly associated with diabetes risk. Rare mutations in WFS1 cause Wolfram syndrome; using a gene-centric approach, we show that variation in WFS1 also predisposes to common type 2 diabetes.
Journal
Nature Genetics – Springer Journals
Published: Jul 1, 2007