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Alzheimer amyloid protein precursor complexes with brain GTP-binding protein Go

Alzheimer amyloid protein precursor complexes with brain GTP-binding protein Go THE most characteristic change in progressive dementia of Alzheimer's type is a tissue deposit of amyloid β/A4 protein1, which is derived from its precursor protein APP (ref. 2). Structural alterations of APP are implicated in the pathogenesis of Alzheimer's disease, but it is not known how they cause the disease. Although APP has a receptor-like architecture2–5, is located on the neuronal surface6, and has a conserved cytoplasmic domain7, no receptor function has been demonstrated for APP. Here we report that APP forms a complex with Go, a major GTP-binding protein in brain. The cytoplasmic APP sequence His 657–Lys 676 shows a specific Go-activating function and is necessary for complex formation. Go protein treated with GTP-γS lost the ability to associate with APP. This suggests that APP is a receptor coupled to Go and that abnormal APP–Go signalling is involved in the Alzheimer's disease process. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Nature Springer Journals

Alzheimer amyloid protein precursor complexes with brain GTP-binding protein Go

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References (25)

Publisher
Springer Journals
Copyright
Copyright © 1993 by Nature Publishing Group
Subject
Science, Humanities and Social Sciences, multidisciplinary; Science, Humanities and Social Sciences, multidisciplinary; Science, multidisciplinary
ISSN
0028-0836
eISSN
1476-4687
DOI
10.1038/362075a0
Publisher site
See Article on Publisher Site

Abstract

THE most characteristic change in progressive dementia of Alzheimer's type is a tissue deposit of amyloid β/A4 protein1, which is derived from its precursor protein APP (ref. 2). Structural alterations of APP are implicated in the pathogenesis of Alzheimer's disease, but it is not known how they cause the disease. Although APP has a receptor-like architecture2–5, is located on the neuronal surface6, and has a conserved cytoplasmic domain7, no receptor function has been demonstrated for APP. Here we report that APP forms a complex with Go, a major GTP-binding protein in brain. The cytoplasmic APP sequence His 657–Lys 676 shows a specific Go-activating function and is necessary for complex formation. Go protein treated with GTP-γS lost the ability to associate with APP. This suggests that APP is a receptor coupled to Go and that abnormal APP–Go signalling is involved in the Alzheimer's disease process.

Journal

Nature – Springer Journals

Published: Mar 4, 1993

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