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Tissue-specific regulation of SIRT1 by calorie restriction

Tissue-specific regulation of SIRT1 by calorie restriction Downloaded from genesdev.cshlp.org on December 11, 2021 - Published by Cold Spring Harbor Laboratory Press RESEARCH COMMUNICATION Nisoli et al. 2005; Civitarese et al. 2007), and this in- Tissue-specific regulation crease is proposed to cause favorable changes in metabo- lism and stress tolerance triggered by this diet. The poly- of SIRT1 by calorie restriction phenol resveratrol has also been proposed to partially 1 1 2 mimic CR by activating SIRT1 to induce beneficial ef- Danica Chen, Joanne Bruno, Erin Easlon, 2 3 3 fects on health (Baur et al. 2006; Lagouge et al. 2006). Su-Ju Lin, Hwei-Ling Cheng, Frederick W. Alt, 1,4 and Leonard Guarente Results and Discussion Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA; Section To address the relationship between SIRT1 activity and of Microbiology, University of California at Davis, Davis, the diet, we first analyzed SIRT1 protein levels in the California 95616, USA; Howard Hughes Medical Institute, liver, white adipose tissue (WAT), and skeletal muscle in The Children’s Hospital, Immune Disease Institute, and mice fed ad libitum (AL) or CR. While SIRT1 was in- Department of Genetics, Harvard Medical School, Boston, duced in the WAT and muscle, as previously reported Massachusetts 02115, USA http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Genes & Development Unpaywall

Tissue-specific regulation of SIRT1 by calorie restriction

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Unpaywall
ISSN
0890-9369
DOI
10.1101/gad.1650608
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Abstract

Downloaded from genesdev.cshlp.org on December 11, 2021 - Published by Cold Spring Harbor Laboratory Press RESEARCH COMMUNICATION Nisoli et al. 2005; Civitarese et al. 2007), and this in- Tissue-specific regulation crease is proposed to cause favorable changes in metabo- lism and stress tolerance triggered by this diet. The poly- of SIRT1 by calorie restriction phenol resveratrol has also been proposed to partially 1 1 2 mimic CR by activating SIRT1 to induce beneficial ef- Danica Chen, Joanne Bruno, Erin Easlon, 2 3 3 fects on health (Baur et al. 2006; Lagouge et al. 2006). Su-Ju Lin, Hwei-Ling Cheng, Frederick W. Alt, 1,4 and Leonard Guarente Results and Discussion Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA; Section To address the relationship between SIRT1 activity and of Microbiology, University of California at Davis, Davis, the diet, we first analyzed SIRT1 protein levels in the California 95616, USA; Howard Hughes Medical Institute, liver, white adipose tissue (WAT), and skeletal muscle in The Children’s Hospital, Immune Disease Institute, and mice fed ad libitum (AL) or CR. While SIRT1 was in- Department of Genetics, Harvard Medical School, Boston, duced in the WAT and muscle, as previously reported Massachusetts 02115, USA

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Genes & Development – Unpaywall

Published: Jun 11, 2008

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