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Regulation of vertebrate left–right asymmetries by extracellular matrix

Regulation of vertebrate left–right asymmetries by extracellular matrix THE vertebrate body is organized along three geometric axes: anterior–posterior, dorsal–ventral and left–right. Left–right axis formation, displayed in heart and gut development, is the least understood, even though it has been studied for many years1–4. In Xenopus laevis gastrulae, a fibronectin-rich extracellular matrix is deposited on the basal surface of ectoderm cells5,6 over which cardiac and visceral primordia move during development. Here I report experiments in which localized perturbation of a small patch of extracellular matrix by microsurgery was correlated with localized randomization of left–right asymmetries. Global perturbation of the extracellular matrix by microinjection of Arg-Gly-Asp peptides or heparinase into the blastocoel resulted in global randomization of left-right asymmetries. From these observations, I suggest that left–right axial information is contained in the extracellular matrix early in development and is independently transmitted to cardiac and visceral primordia. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Nature Springer Journals

Regulation of vertebrate left–right asymmetries by extracellular matrix

Yost, H. Joseph
Nature , Volume 357 (6374) – May 14, 1992
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References (18)

Publisher
Springer Journals
Copyright
Copyright © 1992 by Nature Publishing Group
Subject
Science, Humanities and Social Sciences, multidisciplinary; Science, Humanities and Social Sciences, multidisciplinary; Science, multidisciplinary
ISSN
0028-0836
eISSN
1476-4687
DOI
10.1038/357158a0
Publisher site
See Article on Publisher Site

Abstract

THE vertebrate body is organized along three geometric axes: anterior–posterior, dorsal–ventral and left–right. Left–right axis formation, displayed in heart and gut development, is the least understood, even though it has been studied for many years1–4. In Xenopus laevis gastrulae, a fibronectin-rich extracellular matrix is deposited on the basal surface of ectoderm cells5,6 over which cardiac and visceral primordia move during development. Here I report experiments in which localized perturbation of a small patch of extracellular matrix by microsurgery was correlated with localized randomization of left–right asymmetries. Global perturbation of the extracellular matrix by microinjection of Arg-Gly-Asp peptides or heparinase into the blastocoel resulted in global randomization of left-right asymmetries. From these observations, I suggest that left–right axial information is contained in the extracellular matrix early in development and is independently transmitted to cardiac and visceral primordia.

Journal

Nature – Springer Journals

Published: May 14, 1992

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