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- Publisher
- Wiley
- Copyright
- Copyright © 2013 AABB
- ISSN
- 0041-1132
- eISSN
- 1537-2995
- DOI
- 10.1111/j.1537-2995.2012.03725.x
- pmid
- 22670706
- Publisher site
- See Article on Publisher Site
Abstract
BACKGROUND: Several mechanisms have been proposed to explain the therapeutic effects of intravenous immunoglobulin (IVIG) in immune thrombocytopenia (ITP). Noteworthy, a major role has been attributed to immunoglobulin (Ig)G dimers present in IVIG. It has also been suggested that immune complexes formed between IVIG and the patient's proteins after infusion could contribute to the therapeutic effect of IVIG in several autoimmune disorders. We recently observed that in‐house preparations of polyclonal human IgG derived from small pools of plasma and devoid of IgG dimers were as efficient as IVIG in a mouse model of thrombocytopenia. In this work, we revisited the role of IgG dimers in the therapeutic effects of IVIG in ITP.
Journal
Transfusion – Wiley
Published: Jan 1, 2013