Li Li, Ji Li, J. Rao, Minglin Li, B. Bass, Jian-Ying Wang (1999)
Inhibition of polyamine synthesis induces p53 gene expression but not apoptosis.American journal of physiology. Cell physiology, 276 4
C. Xia, J. Yang, S. Ren, E. Lien (1998)
QSAR analysis of polyamine transport inhibitors in L1210 cells.Journal of drug targeting, 6 1
P. McCann, A. Pegg, A. Sjoerdsma (1987)
Inhibition of polyamine metabolism : biological significance and basis for new therapies
E. Gabrielson, A. Pegg, R. Casero (1999)
The induction of spermidine/spermine N1-acetyltransferase (SSAT) is a common event in the response of human primary non-small cell lung carcinomas to exposure to the new antitumor polyamine analogue N1,N11-bis(ethyl)norspermine.Clinical cancer research : an official journal of the American Association for Cancer Research, 5 7
R. Casero, S. Ervin, P. Celano, S. Baylin, R. Bergeron (1989)
Differential response to treatment with the bis(ethyl)polyamine analogues between human small cell lung carcinoma and undifferentiated large cell lung carcinoma in culture.Cancer research, 49 3
J. Mandel, W. Flintoff (1978)
Isolation of mutant mammalian cells altered in polyamine transportJournal of Cellular Physiology, 97
P. Casara, P. Marchal, J. Wagner, C. Danzin (1989)
5'-{[(Z)-4-amino-2-butenyl]methylamino}-5'-deoxyadenosine: a potent enzyme-activated irreversible inhibitor of S-adenosyl-L-methionine decarboxylase from Escherichia coliJournal of the American Chemical Society, 111
B. Antonsson, F. Conti, AnnaMaria Ciavatta, S. Montessuit, Shareta Lewis, I. Martinou, L. Bernasconi, Alain Bernard, J. Mermod, G. Mazzei, K. Maundrell, F. Gambale, R. Sadoul, J. Martinou (1997)
Inhibition of Bax channel-forming activity by Bcl-2.Science, 277 5324
P. Woster, A. Black, K. Duff, J. Coward, A. Pegg (1989)
Synthesis and biological evaluation of S-adenosyl-1,12-diamino-3-thio-9-azadodecane, a multisubstrate adduct inhibitor of spermine synthase.Journal of medicinal chemistry, 32 6
C. Tabor, H. Tabor (1987)
The speEspeD operon of Escherichia coli. Formation and processing of a proenzyme form of S-adenosylmethionine decarboxylase.The Journal of biological chemistry, 262 33
S. Quesne, A. Fairlamb (1996)
Regulation of a high-affinity diamine transport system in Trypanosoma cruzi epimastigotes.The Biochemical journal, 316 ( Pt 2)
J. Lakanen, J. Coward, A. Pegg (1992)
alpha-Methyl polyamines: metabolically stable spermidine and spermine mimics capable of supporting growth in cells depleted of polyamines.Journal of medicinal chemistry, 35 4
N. Davidson, H. Hahm, D. McCloskey, P. Woster, R. Casero (1999)
Clinical aspects of cell death in breast cancer: the polyamine pathway as a new target for treatment.Endocrine-related cancer, 6 1
C. Bacchi, H. Nathan, S. Hutner, P. McCann, A. Sjoerdsma (1980)
Polyamine metabolism: a potential therapeutic target in trypanosomes.Science, 210 4467
P. McCann, P. McCann, A. Pegg (1992)
Ornithine decarboxylase as an enzyme target for therapy.Pharmacology & therapeutics, 54 2
V. Milović, W. Caspary, J. Stein (1998)
Polyamine Uptake Across the Basolateral Membrane of the Enterocyte Is Mediated by a High-Affinity CarrierDigestion, 59
L. Xiao, P. Celano, A. Mank, A. Pegg, R. Casero (1991)
Characterization of a full-length cDNA which codes for the human spermidine/spermine N1-acetyltransferase.Biochemical and biophysical research communications, 179 1
M. Edwards, D. Stemerick, A. Bitonti, J. Dumont, P. McCann, P. Bey, A. Sjoerdsma (1991)
Antimalarial polyamine analogues.Journal of medicinal chemistry, 34 2
F. Antognoni, S. Duca, A. Kuraishi, Eri Kawabe, T. Fukuchi-Shimogori, K. Kashiwagi, K. Igarashi (1999)
Transcriptional Inhibition of the Operon for the Spermidine Uptake System by the Substrate-binding Protein PotD*The Journal of Biological Chemistry, 274
J. Eiseman, F. Rogers, Yanping Guo, Jaqueline Kauffman, D. Sentz, Matthew Klinger, P. Callery, N. Kyprianou (1998)
Tumor-targeted apoptosis by a novel spermine analogue, 1,12-diaziridinyl-4,9-diazadodecane, results in therapeutic efficacy and enhanced radiosensitivity of human prostate cancer.Cancer research, 58 21
N. Shah, T. Thomas, A. Shirahata, L. Sigal, T. Thomas (1999)
Activation of nuclear factor kappaB by polyamines in breast cancer cells.Biochemistry, 38 45
D. Kramer, S. Vujcic, P. Diegelman, J. Alderfer, J. Miller, J. Black, R. Bergeron, C. Porter (1999)
Polyamine analogue induction of the p53-p21WAF1/CIP1-Rb pathway and G1 arrest in human melanoma cells.Cancer research, 59 6
R. Casero, A. Pegg (1993)
Spermidine/spermine N1‐acetyltransferase — the turning point in polyamine metabolismThe FASEB Journal, 7
S. Baillet, E. Buisine, D. Horvath, L. Maes, B. Bonnet, C. Sergheraert (1996)
2-Amino diphenylsulfides as inhibitors of trypanothione reductase: modification of the side chain.Bioorganic & medicinal chemistry, 4 6
Thierry Rossé, R. Olivier, L. Monney, Monika Rager, S. Conus, I. Fellay, Burkhard Jansen, C. Borner (1998)
Bcl-2 prolongs cell survival after Bax-induced release of cytochrome cNature, 391
R. Casero, P. Celano, S. Ervin, N. Applegren, L. Wiest, A. Pegg (1991)
Isolation and characterization of a cDNA clone that codes for human spermidine/spermine N1-acetyltransferase.The Journal of biological chemistry, 266 2
A. Pegg (1986)
Recent advances in the biochemistry of polyamines in eukaryotes.The Biochemical journal, 234 2
S. Nagarajan, B. Ganem, A. Pegg (1988)
Studies of non-metabolizable polyamines that support growth of SV-3T3 cells depleted of natural polyamines by exposure to alpha-difluoromethylornithine.The Biochemical journal, 254 2
J. Ekstrom, I. Mathews, B. Stanley, A. Pegg, S. Ealick (1999)
The crystal structure of human S-adenosylmethionine decarboxylase at 2.25 A resolution reveals a novel fold.Structure, 7 5
H. Tomitori, K. Kashiwagi, K. Sakata, Y. Kakinuma, K. Igarashi (1999)
Identification of a Gene for a Polyamine Transport Protein in Yeast*The Journal of Biological Chemistry, 274
K. Pastorian, C. Byus (1997)
Tolerance to putrescine toxicity in Chinese hamster ovary cells is associated with altered uptake and export.Experimental cell research, 231 2
D. Hockenbery, Z. Oltvai, Xiao-Ming Yin, C. Milliman, S. Korsmeyer (1993)
Bcl-2 functions in an antioxidant pathway to prevent apoptosisCell, 75
R. Casero, A. Mank, L. Xiao, J. Smith, R. Bergeron, P. Celano (1992)
Steady-state messenger RNA and activity correlates with sensitivity to N1,N12-bis(ethyl)spermine in human cell lines representing the major forms of lung cancer.Cancer research, 52 19
F. Schuber, K. Hong, N. Düzgüneş, D. Papahadjopoulos (1983)
Polyamines as modulators of membrane fusion: aggregation and fusion of liposomes.Biochemistry, 22 26
C. Danzin, P. Marchal, P. Casara (1990)
Irreversible inhibition of rat S-adenosylmethionine decarboxylase by 5'-([(Z)-4-amino-2-butenyl]methylamino)-5'-deoxyadenosine.Biochemical pharmacology, 40 7
R. Bergeron, A. Neims, J. Mcmanis, T. Hawthorne, J. Vinson, R. Bortell, M. Ingeno (1988)
Synthetic polyamine analogues as antineoplastics.Journal of medicinal chemistry, 31 6
U. Regenass, H. Mett, J. Staněk, M. Mueller, D. Kramer, C. Porter (1994)
CGP 48664, a new S-adenosylmethionine decarboxylase inhibitor with broad spectrum antiproliferative and antitumor activity.Cancer research, 54 12
P. Sunkara, S. Baylin, G. Luk (1987)
6 – Inhibitors of Polyamine Biosynthesis: Cellular and in Vivo Effects on Tumor Proliferation
A. Lewin, Guobin Sun, Louise Fudala, H. Navarro, Li-Ming Zhou, P. Popik, and Faynsteyn, P. Skolnick (1998)
Molecular features associated with polyamine modulation of NMDA receptors.Journal of medicinal chemistry, 41 6
G. Fukumoto, C. Byus (1997)
Putrescine export in Xenopus laevis oocytes occurs against a concentration gradient: evidence for a non-diffusional export process.Biochimica et biophysica acta, 1324 2
R. Wickner, C. Tabor, H. Tabor (1970)
Purification of adenosylmethionine decarboxylase from Escherichia coli W: evidence for covalently bound pyruvate.The Journal of biological chemistry, 245 8
S. Aziz, M. Gillespie, P. Crooks, S. Tofiq, C. Tsuboi, J. Olson, M. Gosland (1996)
The potential of a novel polyamine transport inhibitor in cancer chemotherapy.The Journal of pharmacology and experimental therapeutics, 278 1
M. Kobayashi, H. Fujisaki, M. Sugawara, K. Iseki, K. Miyazaki (1999)
The Presence of an Na+/Spermine Antiporter in the Rat Renal Brush‐border MembraneJournal of Pharmacy and Pharmacology, 51
K. Sakata, T. Fukuchi-Shimogori, K. Kashiwagi, K. Igarashi (1997)
Identification of regulatory region of antizyme necessary for the negative regulation of polyamine transport.Biochemical and biophysical research communications, 238 2
R. Bergeron, J. Mcmanis, C. Liu, Y. Feng, W. Weimar, G. Luchetta, Q. Wu, J. Ortiz-Ocasio, J. Vinson, D. Kramer (1994)
Antiproliferative properties of polyamine analogues: a structure-activity study.Journal of medicinal chemistry, 37 21
A. Khomutov, A. Kritsky, E. Artamonova, R. Khomutov (1987)
Polyfunctional O-Substituted Hydroxylamines: Modification of Nucleic Acids, Inhibition of Sam-DecarboxylaseNucleosides, Nucleotides & Nucleic Acids, 6
R. Bergeron, T. Hawthorne, J. Vinson, D. Beck, M. Ingeno (1989)
Role of the methylene backbone in the antiproliferative activity of polyamine analogues on L1210 cells.Cancer research, 49 11
C. Porter, Barbara Ganis, P. Libby, R. Bergeron (1991)
Correlations between polyamine analogue-induced increases in spermidine/spermine N1-acetyltransferase activity, polyamine pool depletion, and growth inhibition in human melanoma cell lines.Cancer research, 51 14
Y. Wu, P. Woster (1993)
Preparation of the pure diastereomeric forms of S-(5'-deoxy-5'-adenosyl)-1-ammonio-4-methylsulfonio-2-cyclopentene and their evaluation as irreversible inhibitors of S-adenosylmethionine decarboxylase from Escherichia coli.Bioorganic & medicinal chemistry, 1 5
R. Casero, P. Celano, S. Ervin, C. Porter, R. Bergeron, P. Libby (1989)
Differential induction of spermidine/spermine N1-acetyltransferase in human lung cancer cells by the bis(ethyl)polyamine analogues.Cancer research, 49 14
D. Anton, R. Kutny (1987)
Escherichia coli S-adenosylmethionine decarboxylase. Subunit structure, reductive amination, and NH2-terminal sequences.The Journal of biological chemistry, 262 6
F. Bellevue, Michelle Boahbedason, R. Wu, P. Woster, R. Casero, D. Rattendi, S. Lane, C. Bacchi (1996)
Structural comparison of alkylpolyamine analogues with potent in vitro antitumor or antiparasitic activityBioorganic & Medicinal Chemistry Letters, 6
R. Baumann, P. McCann, A. Bitonti (1991)
Suppression of Leishmania donovani by oral administration of a bis(benzyl)polyamine analogAntimicrobial Agents and Chemotherapy, 35
D. McCloskey, J. Yang, P. Woster, N. Davidson, R. Casero (1996)
Polyamine analogue induction of programmed cell death in human lung tumor cells.Clinical cancer research : an official journal of the American Association for Cancer Research, 2 3
A. Bitonti, J. Dumont, T. Bush, M. Edwards, D. Stemerick, P. McCann, A. Sjoerdsma (1989)
Bis(benzyl)polyamine analogs inhibit the growth of chloroquine-resistant human malaria parasites (Plasmodium falciparum) in vitro and in combination with alpha-difluoromethylornithine cure murine malaria.Proceedings of the National Academy of Sciences of the United States of America, 86 2
D. Felschow, Z. Mi, J. Staněk, J. Frei, C. Porter (1997)
Selective labelling of cell-surface polyamine-binding proteins on leukaemic and solid-tumour cell types using a new polyamine photoprobe.The Biochemical journal, 328 ( Pt 3)
R. Bergeron, J. Garlich, N. Stolowich (1984)
Reagents for the stepwise functionalization of spermidine, homospermidine, and bis(3-aminopropyl)amineJournal of Organic Chemistry, 49
R. Roemmele, H. Rapoport (1988)
Removal of N-arylsulfonyl groups from hydroxy .alpha.-amino acidsJournal of Organic Chemistry, 53
Lisa Jeffers, D. Church, H. Basu, L. Marton, G. Wilding (1997)
Effects of the polyamine analogues BE-4-4-4-4, BE-3-7-3, and BE-3-3-3 on the proliferation of three prostate cancer cell linesCancer Chemotherapy and Pharmacology, 40
L. Marton, A. Pegg (1995)
Polyamines as targets for therapeutic intervention.Annual review of pharmacology and toxicology, 35
K. Kashiwagi, H. Endo, H. Kobayashi, K. Takio, K. Igarashi (1995)
Spermidine-preferential Uptake System in Escherichia coliThe Journal of Biological Chemistry, 270
H. Yajima, N. Fujii, Y. Hirota, Y. Nasada, Y. Hirai, T. Nakajima (2009)
Studies on peptides. XCVIII. Synthesis of a wasp venom, Polistes mastoparan.International journal of peptide and protein research, 16 5
R. Iyer, Z. Wu, P. Woster, A. Delcour (2000)
Molecular basis for the polyamine-ompF porin interactions: inhibitor and mutant studies.Journal of molecular biology, 297 4
M. Tansy, J. Martin, W. Landin, F. Kendall, S. Melamed (1982)
Spermine and spermidine as inhibitors of gastrointestinal motor activity.Surgery, gynecology & obstetrics, 154 1
HU Rei-Huang, A. Pegg (1997)
Rapid induction of apoptosis by deregulated uptake of polyamine analogues.The Biochemical journal, 328 ( Pt 1)
D. Kramer, S. Vujcic, P. Diegelman, C. White, J. Black, C. Porter (1998)
Polyamine analogue-mediated cell cycle responses in human melanoma cells involves the p53, p21, Rb regulatory pathway.Biochemical Society transactions, 26 4
C. Porter, J. Sufrin (1986)
Interference with polyamine biosynthesis and/or function by analogs of polyamines or methionine as a potential anticancer chemotherapeutic strategy.Anticancer research, 6 4
R. Bergeron, J. Wiegand, C. Sninsky, M. Katovich (1995)
The impact of polyamine analogues on the blood pressure of normotensive and hypertensive rats.Clinical and experimental hypertension, 17 8
D. Campbell (1992)
The synthesis of phosphonate esters; an extension of the Mitsunobu reactionJournal of Organic Chemistry, 57
G. Markham, C. Tabor, H. Tabor (1982)
S-adenosylmethionine decarboxylase of Escherichia coli. Studies on the covalently linked pyruvate required for activity.The Journal of biological chemistry, 257 20
R. Poulin, C. Zhao, S. Verma, R. Charest-Gaudreault, M. Audette (1998)
Dependence of mammalian putrescine and spermidine transport on plasma-membrane potential: identification of an amiloride binding site on the putrescine carrier.The Biochemical journal, 330 ( Pt 3)
A. Pegg (1988)
Polyamine metabolism and its importance in neoplastic growth and a target for chemotherapy.Cancer research, 48 4
H. Yajima, M. Takeyama, J. Kanaki, O. Nishimura, M. Fujino (1978)
Studies on Peptides. LXXX. NG-Mesitylene-2-sulfonylarginineChemical & Pharmaceutical Bulletin, 26
M. Kandpal, B. Tekwani (1997)
Polyamine transport systems of Leishmania donovani promastigotes.Life sciences, 60 20
Hyo Ha, Nilantha Sirisoma, P. Kuppusamy, Jay Zweier, P. Woster, R. Casero (1998)
The natural polyamine spermine functions directly as a free radical scavenger.Proceedings of the National Academy of Sciences of the United States of America, 95 19
H. Ha, J. Yager, P. Woster, R. Casero (1998)
Structural specificity of polyamines and polyamine analogues in the protection of DNA from strand breaks induced by reactive oxygen species.Biochemical and biophysical research communications, 244 1
Anthony Pegg, Richard Poulin, J. Coward (1995)
Use of aminopropyltransferase inhibitors and of non-metabolizable analogs to study polyamine regulation and function.The international journal of biochemistry & cell biology, 27 5
Y. Wu, T. Lawrence, Junkai Guo, P. Woster (1993)
α-cyano-substituted analogoues of decarboxylated S-adenosylmethionine as enzyme activated, irreversible inhibitors of S-adenosylmethionine decarboxylaseBioorganic & Medicinal Chemistry Letters, 3
J. Satriano, Shunji Ishizuka, D. Archer, R. Blantz, Carolyn Kelly (1999)
Regulation of intracellular polyamine biosynthesis and transport by NO and cytokines TNF-alpha and IFN-gamma.The American journal of physiology, 276 4
Y. Li, Alexander MacKerell, M. Egorin, M. Ballesteros, D. Rosen, Y. Wu, D. Blamble, P. Callery (1997)
Comparative molecular field analysis-based predictive model of structure-function relationships of polyamine transport inhibitors in L1210 cells.Cancer research, 57 2
M. Edwards, N. Prakash, D. Stemerick, S. Sunkara, A. Bitonti, G. Davis, J. Dumont, P. Bey (1990)
Polyamine analogues with antitumor activity.Journal of medicinal chemistry, 33 5
B. Bonnet, D. Soullez, E. Davioud‐Charvet, V. Landry, D. Horvath, C. Sergheraert (1997)
New spermine and spermidine derivatives as potent inhibitors of Trypanosoma cruzi trypanothione reductase.Bioorganic & medicinal chemistry, 5 7
N. Saab, E. West, N. Bieszk, C. Preuss, A. Mank, R. Casero, P. Woster (1993)
Synthesis and evaluation of unsymmetrically substituted polyamine analogues as modulators of human spermidine/spermine-N1-acetyltransferase (SSAT) and as potential antitumor agents.Journal of medicinal chemistry, 36 20
A. Pegg, D. Jones, J. Secrist (1988)
Effect of inhibitors of S-adenosylmethionine decarboxylase on polyamine content and growth of L1210 cells.Biochemistry, 27 5
V. Jasys, P. Kelbaugh, D. Nason, D. Phillips, K. Rosnack, A. SaccomanoNicholas, J. Stroh, A. VolkmannRobert, James Forman (1992)
Novel quaternary ammonium salt-containing polyamines from the Agelenopsis aperta funnel-web spiderJournal of Organic Chemistry, 57
R. Bergeron, N. Stolowich, C. Porter (1982)
Reagents for the Selective Secondary N-Acylation of Linear TriaminesSynthesis, 1982
E. Løvaas (1995)
Hypothesis: spermine may be an important epidermal antioxidant.Medical hypotheses, 45 1
P. Cullis, R. Green, L. Merson-Davies, N. Travis (1998)
Chemical highlights of polyamine transport.Biochemical Society transactions, 26 4
R. Ray, B. Zimmerman, S. Mccormack, T. Patel, Leonard Johnson (1999)
Polyamine depletion arrests cell cycle and induces inhibitors p21(Waf1/Cip1), p27(Kip1), and p53 in IEC-6 cells.The American journal of physiology, 276 3
N. Shappell, J. Miller, R. Bergeron, C. Porter (1992)
Differential effects of the spermine analog, N1, N12-bis(ethyl)-spermine, on polyamine metabolism and cell growth in human melanoma cell lines and melanocytes.Anticancer research, 12 4
B. Metcalf, P. Bey, C. Danzin, M. Jung, P. Casara, J. Vevert (1978)
Catalytic irreversible inhibition of mammalian ornithine decarboxylase (E.C.4.1.1.17) by substrate and product analogsJournal of the American Chemical Society, 100
L. Barr, S. Campbell, P. Tamez, R. Casero (1998)
The growth inhibitory effect of N1,N12-bis(ethyl)spermine in small cell lung cancer cells is maintained in cells expressing the c-myc and Ha-ras oncogenes.Clinical cancer research : an official journal of the American Association for Cancer Research, 4 6
N. Seiler, J. Delcros, M. Vaultier*, N. Roch, R. Havouis, F. Douaud, J. Moulinoux (1996)
Bis(7-amino-4-azaheptyl)dimethlysilane and bis(7-ethylamino-4-azaheptyl)dimethylsilane: inhibition of tumor cell growth in vitro and in vivo.Cancer research, 56 24
T. Byers, A. Pegg (1990)
Regulation of polyamine transport in Chinese hamster ovary cellsJournal of Cellular Physiology, 143
R. Baumann, W. Hanson, P. McCann, A. Sjoerdsma, A. Bitonti (1990)
Suppression of both antimony-susceptible and antimony-resistant Leishmania donovani by a bis(benzyl)polyamine analogAntimicrobial Agents and Chemotherapy, 34
B. Erwin, L. Persson, A. Pegg (1984)
Differential inhibition of histone and polyamine acetylases by multisubstrate analogues.Biochemistry, 23 18
A. Pegg, P. McCann (1992)
S-adenosylmethionine decarboxylase as an enzyme target for therapy.Pharmacology & therapeutics, 56 3
Jie Yang, X. Liu, K. Bhalla, C. Kim, A. Ibrado, Jiyang Cai, T. Peng, Dean Jones, Xiaodong Wang (1997)
Prevention of Apoptosis by Bcl-2: Release of Cytochrome c from Mitochondria BlockedScience, 275
Lei Xiao, Celano Paul, A. Mank, C. Griffin, E. Jabs, A. Hawkins, R. Casero (1992)
Structure of the human spermidine/spermine N1-acetyltransferase gene (exon/intron gene organization and localization to Xp22.1).Biochemical and biophysical research communications, 187 3
I. Matsui, L. Wiegand, A. Pegg (1981)
Properties of spermidine N-acetyltransferase from livers of rats treated with carbon tetrachloride and its role in the conversion of spermidine into putrescine.The Journal of biological chemistry, 256 5
R. Bergeron, W. Weimar, G. Luchetta, R. Streiff, J. Wiegand, J. Perrin, K. Schreier, C. Porter, G. Yao, H. Dimova (1995)
Metabolism and pharmacokinetics of N1,N11-diethylnorspermine.Drug metabolism and disposition: the biological fate of chemicals, 23 10
Xiaozhen Xie, R. Gillies, E. Gerner (1997)
Characterization of a Diamine Exporter in Chinese Hamster Ovary Cells and Identification of Specific Polyamine Substrates*The Journal of Biological Chemistry, 272
D. Felschow, J. Macdiarmid, T. Bardos, Ronghui Wu, P. Woster, C. Porter (1995)
Photoaffinity Labeling of a Cell Surface Polyamine Binding Protein (*)The Journal of Biological Chemistry, 270
M. Dolan, M. Fleig, B. Feuerstein, H. Basu, G. Luk, R. Casero, L. Marton (1994)
Effect of 1,19-bis(ethylamino)-5,10,15-triazanonadecane on human tumor xenografts.Cancer research, 54 17
Y. Murakami, S. Matsufuji, T. Kameji, S. Hayashi, K. Igarashi, T. Tamura, Keiji Tanaka, A. Ichihara (1992)
Ornithine decarboxylase is degraded by the 26S proteasome without ubiquitinationNature, 360
P. Marchant, Sasi Dredar, V. Manneh, Othman Alshabanah, H. Matthews, D. Fries, J. Blankenship (1989)
A selective inhibitor of N8-acetylspermidine deacetylation in mice and HeLa cells without effects on histone deacetylation.Archives of biochemistry and biophysics, 273 1
Y. He, T. Suzuki, K. Kashiwagi, K. Igarashi (1994)
Antizyme delays the restoration by spermine of growth of polyamine-deficient cells through its negative regulation of polyamine transport.Biochemical and biophysical research communications, 203 1
S. Aziz, D. Worthen, M. Yatin, K. Ain, P. Crooks (1998)
A unique interaction between polyamine and multidrug resistance (P-glycoprotein) transporters in cultured Chinese hamster ovary cells transfected with mouse mdr-1 gene.Biochemical pharmacology, 56 2
A. Pajunen, A. Crozat, O. Jänne, R. Ihalainen, P. Laitinen, B. Stanley, R. Madhubala, A. Pegg (1988)
Structure and regulation of mammalian S-adenosylmethionine decarboxylase.The Journal of biological chemistry, 263 32
X. Xie, M. Tome, E. Gerner (1997)
Loss of intracellular putrescine pool-size regulation induces apoptosis.Experimental cell research, 230 2
H. Ha, P. Woster, J. Yager, R. Casero (1997)
The role of polyamine catabolism in polyamine analogue-induced programmed cell death.Proceedings of the National Academy of Sciences of the United States of America, 94 21
D. Vassylyev, H. Tomitori, K. Kashiwagi, K. Morikawa, K. Igarashi (1998)
Crystal structure and mutational analysis of the Escherichia coli putrescine receptor. Structural basis for substrate specificity.The Journal of biological chemistry, 273 28
N. Sirisoma, P. Woster (1998)
Synthesis of protected allylic amines via palladium(0)-catalyzed amination of allylic acetatesTetrahedron Letters, 39
D. Kramer, M. Fogel‐Petrovic, P. Diegelman, Jeanine Cooley, R. Bernacki, J. Mcmanis, R. Bergeron, C. Porter, A. Bern (1997)
Effects of novel spermine analogues on cell cycle progression and apoptosis in MALME-3M human melanoma cells.Cancer research, 57 24
L. Covassin, M. Desjardins, R. Charest-Gaudreault, M. Audette, M. Bonneau, R. Poulin (1999)
Synthesis of spermidine and norspermidine dimers as high affinity polyamine transport inhibitors.Bioorganic & medicinal chemistry letters, 9 12
R. Bergeron, G. Yao, H. Yao, W. Weimar, C. Sninsky, B. Raisler, Y. Feng, Q. Wu, F. Gao (1996)
Metabolically programmed polyamine analogue antidiarrheals.Journal of medicinal chemistry, 39 13
K. Igarashi, K. Kashiwagi (2000)
Polyamines: mysterious modulators of cellular functions.Biochemical and biophysical research communications, 271 3
D. Shao, Lei Xiao, H. Ha, R. Casero (1996)
Isolation of a polyamine transport deficient cell line from the human non‐small cell lung carcinoma line NCI H157Journal of Cellular Physiology, 166
D. McCloskey, R. Casero, P. Woster, N. Davidson (1995)
Induction of programmed cell death in human breast cancer cells by an unsymmetrically alkylated polyamine analogue.Cancer research, 55 15
K. Tang, Roy Mariuzza, J. Coward (1981)
Synthesis and evaluation of some stable multisubstrate adducts as specific inhibitors of spermidine synthase.Journal of medicinal chemistry, 24 11
R. Elliott, N. Marks, M. Berg, P. Portoghese (1985)
Synthesis and biological evaluation of phosphonamidate peptide inhibitors of enkephalinase and angiotensin-converting enzyme.Journal of medicinal chemistry, 28 9
A. Zheliaskova, S. Naydenova, A. Petrov (2000)
Interaction of phospholipid bilayers with polyamines of different lengthEuropean Biophysics Journal, 29
Donglin Guo, Zhe Lu (2000)
Mechanism of Cgmp-Gated Channel Block by Intracellular PolyaminesThe Journal of General Physiology, 115
A. Pegg, R. Wechter, R. Poulin, P. Woster, J. Coward (1989)
Effect of S-adenosyl-1,12-diamino-3-thio-9-azadodecane, a multisubstrate adduct inhibitor of spermine synthase, on polyamine metabolism in mammalian cells.Biochemistry, 28 21
H. Basu, M. Pellarin, B. Feuerstein, D. Deen, L. Marton (1991)
Effect of N1,N14‐bis‐(ethyl)‐homospermine (BE‐4–4‐4) on the growth of U‐251 MG and SF‐188 human brain tumor cellsInternational Journal of Cancer, 48
Y. Wu, P. Woster (1995)
Irreversible inhibition of human S-adenosylmethionine decarboxylase by the pure diastereomeric forms of S-(5'-deoxy-5'-adenosyl)-1-ammonio-4- methylsulfonio-2-cyclopentene (AdoMac).Biochemical pharmacology, 49 8
P. Brachet, J. Long, E. Siedel (1998)
Selective sites for polyamine binding to rabbit intestinal brush-border membranes.Biochemical pharmacology, 56 4
Junqing Guo, Yong Wu, D. Rattendi, Cyrus Bacchi, P. Woster (1995)
S-(5'-deoxy-5'-adenosyl)-1-aminoxy-4-(methylsulfonio)-2-cyclopentene (AdoMao): an irreversible inhibitor of S-adenosylmethionine decarboxylase with potent in vitro antitrypanosomal activity.Journal of medicinal chemistry, 38 10
G. Marverti, G. Piccinini, Stefania Ghiaroni, D. Barbieri, D. Quaglino, M. Moruzzi (1998)
N1,N12‐bis(ethyl)spermine effect on growth of cis‐diamminedichloroplatinum(II)‐sensitive and ‐resistant human ovarian‐carcinoma cell linesInternational Journal of Cancer, 78
H. Ha, P. Woster, R. Casero (1998)
Unsymmetrically substituted polyamine analogue induces caspase-independent programmed cell death in Bcl-2-overexpressing cells.Cancer research, 58 13
R. Casero, S. Baylin (1989)
13 – CONCEPTS FOR DERIVING SPECIFIC INHIBITORS OF POLYAMINE BIOSYNTHESIS–HUMAN LUNG CANCER CELLS AS A MODEL SYSTEM
C. Porter, R. Bernacki, J. Miller, R. Bergeron (1993)
Antitumor activity of N1,N11-bis(ethyl)norspermine against human melanoma xenografts and possible biochemical correlates of drug action.Cancer research, 53 3
A. Bitonti, T. Bush, P. McCann (1989)
Regulation of polyamine biosynthesis in rat hepatoma (HTC) cells by a bisbenzyl polyamine analogue.The Biochemical journal, 257 3
P. Cullis, R. Wolfenden, L. Cousens, B. Alberts (1982)
Inhibition of histone acetylation by N-[2-(S-coenzyme A)acetyl] spermidine amide, a multisubstrate analog.The Journal of biological chemistry, 257 20
Y. Blais, Chenqi Zhao, M. Huber, M. Audette, F. Labrie, R. Poulin (1996)
Growth‐independent induction of spermidine transport by IL‐4 and IL‐13 in ZR‐75‐1 human breast cancer cellsInternational Journal of Cancer, 67
Keith Williams (1997)
Modulation and block of ion channels: a new biology of polyamines.Cellular signalling, 9 1
B. Chang, Y. Liang, D. Miller, R. Bergeron, C. Porter, G. Wang (1993)
Effects of diethyl spermine analogues in human bladder cancer cell lines in culture.The Journal of urology, 150 4
C. Stefanelli, F. Bonavita, I. Stanic’, C. Pignatti, F. Flamigni, C. Guarnieri, C. Caldarera (1999)
Spermine triggers the activation of caspase‐3 in a cell‐free model of apoptosisFEBS Letters, 451
M. Huber, Joële Pelletier, K. Torossian, P. Dionne, Isabelle Gamache, R. Charest-Gaudreault, M. Audette, R. Poulin (1996)
2,2′-Dithiobis(N-ethyl-spermine-5-carboxamide) Is a High Affinity, Membrane-impermeant Antagonist of the Mammalian Polyamine Transport System*The Journal of Biological Chemistry, 271
V. Reddy, A. Valasinas, A. Sarkar, H. Basu, L. Marton, B. Frydman (1998)
Conformationally restricted analogues of 1N,12N-bisethylspermine: synthesis and growth inhibitory effects on human tumor cell lines.Journal of medicinal chemistry, 41 24
Z. Mi, D. Kramer, J. Miller, R. Bergeron, R. Bernacki, C. Porter (1998)
Human prostatic carcinoma cell lines display altered regulation of polyamine transport in response to polyamine analogs and inhibitorsThe Prostate, 34
L. Xiao, R. Casero (1996)
Differential transcription of the human spermidine/spermine N1-acetyltransferase (SSAT) gene in human lung carcinoma cells.The Biochemical journal, 313 ( Pt 2)
C. Berchtold, P. Tamez, T. Kensler, R. Casero (1998)
Inhibition of cell growth in CaCO2 cells by the polyamine analogue N1,N12‐bis(ethyl)spermine is preceded by a reduction in MYC oncoprotein levelsJournal of Cellular Physiology, 174
R. Bernacki, R. Bergeron, C. Porter (1992)
Antitumor activity of N,N'-bis(ethyl)spermine homologues against human MALME-3 melanoma xenografts.Cancer research, 52 9
F. Ragione, A. Pegg (1983)
Studies of the specificity and kinetics of rat liver spermidine/spermine N1-acetyltransferase.The Biochemical journal, 213 3
Donglin Guo, Zhe Lu (2000)
Mechanism of Irk1 Channel Block by Intracellular PolyaminesThe Journal of General Physiology, 115
K. Kashiwagi, Sanae Shibuya, H. Tomitori, A. Kuraishi, K. Igarashi (1997)
Excretion and Uptake of Putrescine by the PotE Protein in Escherichia coli*The Journal of Biological Chemistry, 272
S. Sugiyama, Y. Matsuo, D. Vassylyev, M. Matsushima, K. Morikawa, K. Maenaka, K. Kashiwagi, K. Igarashi (1996)
The 1.8‐Å X‐ray structure of the Escherichia coli PotD protein complexed with spermidine and the mechanism of polyamine bindingProtein Science, 5
H. Basu, M. Pellarin, B. Feuerstein, A. Shirahata, K. Samejima, D. Deen, L. Marton (1993)
Interaction of a polyamine analogue, 1,19-bis-(ethylamino)-5,10,15- triazanonadecane (BE-4-4-4-4), with DNA and effect on growth, survival, and polyamine levels in seven human brain tumor cell lines.Cancer research, 53 17
C. Porter, F. Berger, A. Pegg, B. Ganis, R. Bergeron (1987)
Regulation of ornithine decarboxylase activity by spermidine and the spermidine analogue N1N8-bis(ethyl)spermidine.The Biochemical journal, 242 2
H. Basu, M. Pellarin, B. Feuerstein, D. Deen, L. Marton (1993)
Effects of the polyamine analogs BE-3-7-3, 3-8-3, and BE-3-8-3 on human brain tumor cell growth and survival.Anticancer research, 13 5A
D. Kramer, R. Khomutov, Y. Bukin, A. Khomutov, C. Porter (1989)
Cellular characterization of a new irreversible inhibitor of S-adenosylmethionine decarboxylase and its use in determining the relative abilities of individual polyamines to sustain growth and viability of L1210 cells.The Biochemical journal, 259 2
J. Lin, J. Cashman (1997)
Detoxication of tyramine by the flavin-containing monooxygenase: stereoselective formation of the trans oxime.Chemical research in toxicology, 10 8
PW Durbin, B. Kullgren, N. Jeung, J. Xu, SJ Rodgers, KN Raymond (1996)
Octadentate catecholamide ligands for Pu(IV) based on linear or preorganized molecular backbonesHuman & Experimental Toxicology, 15
B. Bonnet, D. Soullez, S. Girault, L. Maes, V. Landry, E. Davioud‐Charvet, C. Sergheraert (2000)
Trypanothione reductase inhibition/trypanocidal activity relationships in a 1,4-bis(3-aminopropyl)piperazine series.Bioorganic & medicinal chemistry, 8 1
R. Casero, B. Go, H. Theiss, J. Smith, S. Baylin, G. Luk (1987)
Cytotoxic response of the relatively difluoromethylornithine-resistant human lung tumor cell line NCI H157 to the polyamine analogue N1,N8-bis(ethyl)spermidine.Cancer research, 47 15
J. Staněk, G. Caravatti, H. Capraro, P. Furet, H. Mett, P. Schneider, U. Regenass (1993)
S-adenosylmethionine decarboxylase inhibitors: new aryl and heteroaryl analogues of methylglyoxal bis(guanylhydrazone).Journal of medicinal chemistry, 36 1
P. Bartlett, J. Hanson, P. Giannousis (1990)
Potent inhibition of pepsin and penicillopepsin by phosphorus-containing peptide analoguesJournal of Organic Chemistry, 55
P. Ferchmin, D. Pérez, Michelle Biello (2000)
Spermine is neuroprotective against anoxia and N-methyl-d-aspartate in hippocampal slicesBrain Research, 859
J. Lin, C. Berkman, J. Cashman (1996)
N-oxygenation of primary amines and hydroxylamines and retroreduction of hydroxylamines by adult human liver microsomes and adult human flavin-containing monooxygenase 3.Chemical research in toxicology, 9 7
P. Karahalios, P. Mamos, D. Vynios, D. Papaioannou, D. Kalpaxis (1998)
The effect of acylated polyamine derivatives on polyamine uptake mechanism, cell growth, and polyamine pools in Escherichia coli, and the pursuit of structure/activity relationships.European journal of biochemistry, 251 3
N. Seiler, J. Delcros, J. Moulinoux (1996)
Polyamine transport in mammalian cells. An update.The international journal of biochemistry & cell biology, 28 8
J. Coward (1982)
Chapter 25. Polyamine Metabolism - Recent Developments and Implications for the Design of New Chemotherapeutic AgentsAnnual Reports in Medicinal Chemistry, 17
K. Torossian, M. Audette, R. Poulin (1996)
Substrate protection against inactivation of the mammalian polyamine-transport system by 1-ethyl-3-(3-dimethylaminopropyl)carbodi-imide.The Biochemical journal, 319 ( Pt 1)
G. Fukumoto, C. Byus (1996)
A kinetic characterization of putrescine and spermidine uptake and export in human erythrocytes.Biochimica et biophysica acta, 1282 1
M. Edwards, R. Snyder, D. Stemerick (1991)
Synthesis and DNA-binding properties of polyamine analogues.Journal of medicinal chemistry, 34 8
Journal of Medicinal Chemistry – Pubmed
Published: Feb 8, 2001
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