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M.A. Abdul-Ghani, C. Jenkinson, D. Richardson, R.A. DeFronzo (2006)
Insulin secretion and insulin action in subjects with impaired fasting glucose and impaired glucose tolerance: results from the Veterans Administration Genetic Epidemiology Study (VAGES)Diabetes, 55
A. Calí, S. Caprio (2008)
Prediabetes and type 2 diabetes in youth: an emerging epidemic disease?Current Opinion in Endocrinology, Diabetes and Obesity, 15
Q. Qiao, P. Jousilahti, J. Eriksson, J. Tuomilehto (2003)
Predictive properties of impaired glucose tolerance for cardiovascular risk are not explained by the development of overt diabetes during follow-up.Diabetes care, 26 10
K. Choi, J. Lee, D. Kim, S. Kim, D. Shin, N. Kim, I. Park, D. Choi, S. Baik (2002)
Comparison of ADA and WHO criteria for the diagnosis of diabetes in elderly KoreansDiabetic Medicine, 19
M. Coutinho, H. Gerstein, Y. Wang, S. Yusuf (1999)
The relationship between glucose and incident cardiovascular events. A metaregression analysis of published data from 20 studies of 95,783 individuals followed for 12.4 years.Diabetes care, 22 2
K. Osei, T. Gaillard, D. Schuster (1997)
Pathogenetic Mechanisms of Impaired Glucose Tolerance and Type II Diabetes in African-Americans: The significance of insulin secretion, insulin sensitivity, and glucose effectivenessDiabetes Care, 20
R. DeFronzo (1997)
Insulin resistance: a multifaceted syndrome responsible for NIDDM, obesity, hypertension, dyslipidaemia and atherosclerosis.The Netherlands journal of medicine, 50 5
M. Abdul-Ghani, M. Matsuda, R. Jani, C. Jenkinson, D. Coletta, K. Kaku, R. DeFronzo (2008)
The relationship between fasting hyperglycemia and insulin secretion in subjects with normal or impaired glucose tolerance.American journal of physiology. Endocrinology and metabolism, 295 2
F. Vegt, J. Dekker, C. Stehouwer, G. Nijpels, L. Bouter, R. Heine (1998)
The 1997 American Diabetes Association Criteria Versus the 1985 World Health Organization Criteria for the Diagnosis of Abnormal Glucose Tolerance: Poor agreement in the Hoorn StudyDiabetes Care, 21
G.M. Reaven (1988)
Banting lecture 1988. Role of insulin resistance in human diseaseDiabetes, 37
N. Gungor, T. Hannon, I. Libman, F. Bacha, S. Arslanian (2005)
Type 2 diabetes mellitus in youth: the complete picture to date.Pediatric clinics of North America, 52 6
W. Pimenta, M. Santos, N. Cruz, F. Aragon, C. Padovani, J. Gerich (2002)
Brazilian individuals with impaired glucose tolerance are characterized by impaired insulin secretion.Diabetes & metabolism, 28 6 Pt 1
D. Nathan, M. Davidson, R. DeFronzo, R. Heine, R. Henry, R. Pratley, B. Zinman (2007)
Impaired Fasting Glucose and Impaired Glucose ToleranceDiabetes Care, 30
M. Abdul-Ghani, C. Jenkinson, D. Richardson, D. Tripathy, R. DeFronzo (2006)
Insulin Secretion and Action in Subjects With Impaired Fasting Glucose and Impaired Glucose ToleranceDiabetes, 55
Desmond Williams, B. Cadwell, Yiling Cheng, C. Cowie, E. Gregg, L. Geiss, M. Engelgau, K. Narayan, G. Imperatore (2005)
Prevalence of Impaired Fasting Glucose and Its Relationship With Cardiovascular Disease Risk Factors in US Adolescents, 1999–2000Pediatrics, 116
Q. Qiao, G. Hu, J. Tuomilehto, T. Nakagami, B. Balkau, K. Borch-Johnsen, A. Ramachandran, V. Mohan, S. Iyer, M. Tominaga, Y. Kiyohara, I. Kato, K. Okubo, M. Nagai, S. Shibazaki, Ze Yang, Zhifu Tong, Qinying Fan, B. Wang, S. Chew, B. Tan, D. Heng, S. Emmanuel, N. Tajima, Y. Iwamoto, C. Snehalatha, V. Vijay, A. Kapur, Yanhu Dong, H. Nan, Weiguo Gao, Haiyan Shi, Fangming Fu (2003)
Age- and sex-specific prevalence of diabetes and impaired glucose regulation in 11 Asian cohorts.Diabetes care, 26 6
C. Alexander, P. Landsman, S. Teutsch, S. Haffner (2003)
NCEP-defined metabolic syndrome, diabetes, and prevalence of coronary heart disease among NHANES III participants age 50 years and older.Diabetes, 52 5
G. Reaven, C. Hollenbeck, Chii-Yang Jeng, Min Wu, Y. Chen (1988)
Measurement of Plasma Glucose, Free Fatty Acid, Lactate, and Insulin for 24 h in Patients With NIDDMDiabetes, 37
J. Barzilay, C. Spiekerman, P. Wahl, L. Kuller, M. Cushman, C. Furberg, A. Dobs, J. Polak, P. Savage (1999)
Cardiovascular disease in older adults with glucose disorders: comparison of American Diabetes Association criteria for diabetes mellitus with WHO criteriaThe Lancet, 354
A. Gastaldelli, E. Ferrannini, E. Ferrannini, Y. Miyazaki, M. Matsuda, R. DeFronzo (2003)
Beta-cell dysfunction and glucose intolerance: results from the San Antonio metabolism (SAM) studyDiabetologia, 47
J. Tuomilehto, J. Lindstrom, S. Keinanen-Kiukaanniemie, L. Hiltunen, S. Kivelä, G. Gallus, M. Garancini, A. Schranz, L. Bouter, J. Dekker, R. Heine, G. Nijpels, A. Pająk, C. Castell, G. Lloveras, R. Tresserras, P. Pablos-Velasco, F. Martínez-Martín, F. Rodriguez-Perez, R. Gabriel, M. Serrano-Ríos, M. Pladevall, J. Muñiz, M. Eliasson, B. Stegmayr, V. Lundberg, N. Unwin, K. George, M. Alberti, L. Hayes, K. Borch-Johnsen, J. Eriksson, Q. Qiao, G. Hu, B. Balkau (2003)
Age- and sex-specific prevalences of diabetes and impaired glucose regulation in 13 European cohorts.Diabetes care, 26 1
R. Weiss, Sara Taksali, W. Tamborlane, T. Burgert, M. Savoye, S. Caprio (2005)
Predictors of changes in glucose tolerance status in obese youth.Diabetes care, 28 4
(2008)
Decreased non-insulin-dependent glucose clearance contributes to the rise in fasting plasma glucose in the nondiabetic range.
Stephen Cook, M. Weitzman, P. Auinger, Michael Nguyen, W. Dietz (2003)
Prevalence of a metabolic syndrome phenotype in adolescents: findings from the third National Health and Nutrition Examination Survey, 1988-1994.Archives of pediatrics & adolescent medicine, 157 8
T. Wasada, H. Kuroki, K. Katsumori, H. Arii, A. Sato, K. Aoki, S. Jimba, G. Hanai (2004)
Who are more insulin resistant, people with IFG or people with IGT?Diabetologia, 47
R. DeFronzo (2009)
From the Triumvirate to the Ominous Octet: A New Paradigm for the Treatment of Type 2 Diabetes MellitusDiabetes, 58
R. DeFronzo (2006)
Is insulin resistance atherogenic? Possible mechanisms.Atherosclerosis. Supplements, 7 4
J. Tuomilehto, J. Lindström, J. Eriksson, T. Valle, H. Hämäläinen, P. Ilanne-Parikka, S. Keinänen-Kiukaanniemi, M. Laakso, A. Louheranta, M. Rastas, V. Salminen, S. Aunola, Z. Cepaitis, V. Moltchanov, M. Hakumäki, M. Mannelin, V. Martikkala, J. Sundvall, M. Uusitupa (2001)
Prevention of type 2 diabetes mellitus by changes in lifestyle among subjects with impaired glucose tolerance.The New England journal of medicine, 344 18
M. Harris, R. Eastman, C. Cowie, K. Flegal, M. Eberhardt (1997)
Comparison of Diabetes Diagnostic Categories in the U.S. Population According to 1997 American Diabetes Association and 1980–1985 World Health Organization Diagnostic CriteriaDiabetes Care, 20
A. Festa, R. D'Agostino, A. Hanley, A. Karter, M. Saad, S. Haffner (2004)
Differences in insulin resistance in nondiabetic subjects with isolated impaired glucose tolerance or isolated impaired fasting glucose.Diabetes, 53 6
Q. Qiao, T. Nakagami, J. Tuomilehto, K. Borch-Johnsen, B. Balkau, Y. Iwamoto, N. Tajima, T. Group (2000)
Comparison of the fasting and the 2-h glucose criteria for diabetes in different Asian cohortsDiabetologia, 43
M. Abdul-Ghani, M. Matsuda, R. DeFronzo (2008)
Strong association between insulin resistance in liver and skeletal muscle in non‐diabetic subjectsDiabetic Medicine, 25
W. Knowler, E. Barrett-Connor, S. Fowler, R. Hamman, J. Lachin, Elizabeth Walker, David Nathan (2002)
Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin.The New England journal of medicine, 346 6
A. Calí, R. Bonadonna, M. Trombetta, R. Weiss, S. Caprio (2008)
Metabolic abnormalities underlying the different prediabetic phenotypes in obese adolescents.The Journal of clinical endocrinology and metabolism, 93 5
S. Haffner, M. Temprosa, J. Crandall, S. Fowler, R. Goldberg, E. Horton, S. Marcovina, K. Mather, T. Orchard, R. Ratner, E. Barrett-Connor (2005)
Intensive lifestyle intervention or metformin on inflammation and coagulation in participants with impaired glucose tolerance.Diabetes, 54 5
T. Haeften, W. Pimenta, A. Mitrakou, M. Korytkowski, T. Jenssen, H. Yki-Jărvinen, J. Gerich (2002)
Disturbances in β-Cell Function in Impaired Fasting GlycemiaDiabetes, 51
A. Calí, C. Man, C. Cobelli, J. Dziura, Aisha Seyal, Melissa Shaw, Karin Allen, Shu Chen, S. Caprio (2009)
Primary Defects in β-Cell Function Further Exacerbated by Worsening of Insulin Resistance Mark the Development of Impaired Glucose Tolerance in Obese AdolescentsDiabetes Care, 32
rosiglitazone Investigators, H. Gerstein, S. Yusuf, J. Bosch, J. Pogue, P. Sheridan, N. Dinccag, M. Hanefeld, B. Hoogwerf, M. Laakso, V. Mohan, J. Shaw, B. Zinman, R. Holman (2006)
Effect of rosiglitazone on the frequency of diabetes in patients with impaired glucose tolerance or impaired fasting glucose: a randomised controlled trialThe Lancet, 368
N. Unwin, J. Shaw, P. Zimmet, K. Alberti (2002)
Impaired glucose tolerance and impaired fasting glycaemia: the current status on definition and interventionDiabetic Medicine, 19
J. Shaw, P. Zimmet, M. Courten, G. Dowse, P. Chitson, H. Gareeboo, F. Hemraj, D. Fareed, J. Tuomilehto, K. Alberti (1999)
Impaired fasting glucose or impaired glucose tolerance. What best predicts future diabetes in Mauritius?Diabetes care, 22 3
W. Knowler, R. Hamman, S. Edelstein, E. Barrett-Connor, D. Ehrmann, E. Walker, S. Fowler, D. Nathan, S. Kahn (2005)
Prevention of type 2 diabetes with troglitazone in the Diabetes Prevention Program.Diabetes, 54 4
L. Groop, R. Bonadonna, S. Delprato, K. Ratheiser, Kathy Zyck, E. Ferrannini, R. DeFronzo (1989)
Glucose and free fatty acid metabolism in non-insulin-dependent diabetes mellitus. Evidence for multiple sites of insulin resistance.The Journal of clinical investigation, 84 1
S. Saydah, M. Miret, J. Sung, C. Varas, D. Gause, F. Brancati (2001)
Postchallenge hyperglycemia and mortality in a national sample of U.S. adults.Diabetes care, 24 8
D. Dunstan, P. Zimmet, T. Welborn, M. Courten, A. Cameron, R. Sicree, T. Dwyer, S. Colagiuri, D. Jolley, M. Knuiman, R. Atkins, J. Shaw (2002)
The rising prevalence of diabetes and impaired glucose tolerance: the Australian Diabetes, Obesity and Lifestyle Study.Diabetes care, 25 5
C. Meyer, W. Pimenta, H.J. Woerle (2006)
Different mechanisms for impaired fasting glucose and impaired postprandial glucose tolerance in humansDiabetes Care, 29
G. Ko, J. Chan, Jean Woo, C. Cockram (1998)
Use of the 1997 American Diabetes Association Diagnostic Criteria for Diabetes in a Hong Kong Chinese PopulationDiabetes Care, 21
R. Jani, M. Molina, M. Matsuda (2008)
Decreased noninsulin dependent glucose clearance contributes to the rise in FPG in the non-diabetic rangeDiabetes Care, 31
M. Davidson, P. Landsman, C. Alexander (2003)
Lowering the criterion for impaired fasting glucose will not provide clinical benefit.Diabetes care, 26 12
S. Genuth, K. Alberti, P. Bennett, J. Buse, R. DeFronzo, R. Kahn, J. Kitzmiller, W. Knowler, H. Lebovitz, Å. Lernmark, D. Nathan, J. Palmer, R. Rizza, C. Saudek, J. Shaw, M. Steffes, M. Stern, J. Tuomilehto, P. Zimmet (2003)
Follow-up report on the diagnosis of diabetes mellitus.Diabetes care, 26 11
H. Gerstein, S. Yusuf, J. Bosch (2006)
The DREAM trial – Authors' replyThe Lancet, 368
G. Reaven (1988)
Role of Insulin Resistance in Human DiseaseDiabetes, 37
H. Larsson, G. Berglund, F. Lindgärde, B. Ahrén (1998)
Comparison of ADA and WHO criteria for diagnosis of diabetes and glucose intoleranceDiabetologia, 41
D.M. Nathan, M.B. Davidson, R.A. DeFronzo (2007)
Impaired fasting glucose and impaired glucose tolerance: implications for careDiabetes Care, 30
E. Cersosimo, R. DeFronzo (2006)
Insulin resistance and endothelial dysfunction: the road map to cardiovascular diseasesDiabetes/Metabolism Research and Reviews, 22
K. Borch-Johnsen, A. Neil, B. Balkau, S. Larsen, A. Nissinen, J. Pekkanen, J. Tuomilehto, P. Jousilahti, J. Lindstrom, M. Pyorala, K. Pyörälä, E. Eschwège, G. Gallus, M. Garancini, L. Bouter, J. Dekker, R. Heine, G. Nijpels, C. Stehouwer, E. Feskens, D. Kromhout, M. Peltonen, A. Pająk, J. Eriksson, Q. Qiao (2001)
Glucose tolerance and cardiovascular mortality: comparison of fasting and 2-hour diagnostic criteria.Archives of internal medicine, 161 3
S. Kahn (2003)
The relative contributions of insulin resistance and beta-cell dysfunction to the pathophysiology of Type 2 diabetesDiabetologia, 46
M. Abdul-Ghani, Marjorie Molina-Carrión, R. Jani, C. Jenkinson, R. DeFronzo (2008)
Adipocytes in subjects with impaired fasting glucose and impaired glucose tolerance are resistant to the anti-lipolytic effect of insulinActa Diabetologica, 45
Momin Gabir, R. Hanson, D. Dabelea, G. Imperatore, J. Roumain, P. Bennett, W. Knowler (2000)
The 1997 American Diabetes Association and 1999 World Health Organization criteria for hyperglycemia in the diagnosis and prediction of diabetes.Diabetes care, 23 8
C. Weyer, C. Bogardus, R. Pratley (1999)
Metabolic characteristics of individuals with impaired fasting glucose and/or impaired glucose tolerance.Diabetes, 48 11
Helena Larsson, B. Ahrén (1998)
Glucose-dependent arginine stimulation test for characterization of islet function: studies on reproducibility and priming effect of arginineDiabetologia, 41
S. Genuth (2003)
Lowering the criterion for impaired fasting glucose is in order.Diabetes care, 26 12
S. Genuth, K.G. Alberti, P. Bennett (2003)
Expert Committee on the diagnosis and classification of diabetes mellitus. Follow-up report on the diagnosis of diabetes mellitusDiabetes Care, 26
C. Meyer, W. Pimenta, H. Woerle, T. Haeften, E. Szoke, A. Mitrakou, J. Gerich (2006)
Different Mechanisms for Impaired Fasting Glucose and Impaired Postprandial Glucose Tolerance in Humans A table elsewhere in this issue shows conventional and Système International (SI) units and conversion factors for many substances.Diabetes Care, 29
M. Abdul-Ghani, Muhammad Sabbah, J. Kher, O. Minuchin, P. Vardi, I. Raz (2006)
Different contributions of insulin resistance and beta‐cell dysfunction in overweight Israeli Arabs with IFG and IGTDiabetes/Metabolism Research and Reviews, 22
M.A. Abdul-Ghani, D. Tripathy, R.A. DeFronzo (2006)
Contribution of beta cell dysfunction and insulin resistance to the pathogenesis of impaired glucose tolerance and impaired fasting glucoseDiabetes Care, 29
M. Abdul-Ghani, D. Tripathy, R. DeFronzo (2006)
Contributions of β-Cell Dysfunction and Insulin Resistance to the Pathogenesis of Impaired Glucose Tolerance and Impaired Fasting Glucose A table elsewhere in this issue shows conventional and Système International (SI) units and conversion factors for many substances.Diabetes Care, 29
M. Laakso, J. Žilinskaitė, T. Hansen, T. Boesgaard, M. Vänttinen, A. Stančáková, P. Jansson, F. Pellmé, J. Holst, T. Kuulasmaa, M. Hribal, G. Sesti, N. Stefan, A. Fritsche, HU Häring, O. Pedersen, U. Smith, U. Smith (2008)
Insulin sensitivity, insulin release and glucagon-like peptide-1 levels in persons with impaired fasting glucose and/or impaired glucose tolerance in the EUGENE2 studyDiabetologia, 51
R. DeFronzo (2004)
Dysfunctional fat cells, lipotoxicity and type 2 diabetesInternational Journal of Clinical Practice, 58
E. Ferrannini, A. Gastaldelli, Y. Miyazaki, M. Matsuda, A. Mari, R. DeFronzo (2005)
beta-Cell function in subjects spanning the range from normal glucose tolerance to overt diabetes: a new analysis.The Journal of clinical endocrinology and metabolism, 90 1
The term prediabetes refers to subjects with impaired fasting glucose and/or impaired glucose tolerance who are at increased risk for type 2 diabetes mellitus. Although both types of patients are at increased risk for developing type 2 diabetes mellitus and cardiovascular disease, they manifest distinct metabolic abnormalities. In this article, we summarize the metabolic abnormalities that characterize each state and the contribution of these metabolic abnormalities to the increased risk of diabetes and cardiovascular disease.
Current Diabetes Reports – Springer Journals
Published: May 22, 2009
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