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- Publisher
- Wiley
- Copyright
- Copyright © 2014 Wiley Subscription Services, Inc., A Wiley Company
- ISSN
- 1615-4150
- eISSN
- 1615-4169
- DOI
- 10.1002/adsc.201400542
- Publisher site
- See Article on Publisher Site
Abstract
Difluoroalkylated aromatics are important structural motifs in pharmaceutical and agrochemical applications. Herein, we report their synthesis by a mild, efficient, and convenient method using visible light photoredox catalysis. A variety of unactivated aromatics were difluoroalkylated with ethyl 2‐bromo‐2,2‐difluoroacetate (BrCF2CO2Et) in the presence of the triscyclometalated Ir complex fac‐[Ir(ppy)3] under visible light irradiation at room temperature. It is shown that reaction outcomes containing the CF2CO2Et moiety can be converted to a variety of other CF2‐containing aromatics, demonstrating the synthetic utility of the present method.
Journal
Advanced Synthesis & Catalysis – Wiley
Published: Mar 15, 2015
Keywords: ; ; ; ;