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VIRAL KERATITIS

VIRAL KERATITIS Of the viruses which commonly cause superficial eye disease, only herpes simplex and varicella zoster appear amenable to specific treatment at present. Superficial herpetic corneal ulcers respond well to a number of nucleoside and nucleotide derivatives applied tropically, and this is an excellent clinical model in which to test new agents in controlled trials. In such studies, combinations of alpha-interferons with acyclovir or trifluorothymidine have been shown to be more effective than either alone. No strategy has been found to affect recurrences of herpes simplex keratitis. Furthermore, deep stromol disease, uveitis and infections following corneal transplants are more difficult to treat because persistent inflammation does not necessarily reflect persistent viral replication, and may be aggravated by drug toxicity. Controlled trials in herpes zoster ophthalmicus have recently shown that there is a definite advantage in using antiviral agents over steroids. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png British Medical Bulletin Oxford University Press

VIRAL KERATITIS

McGill, James; Scott, G M
British Medical Bulletin , Volume 41 (4) – Jan 1, 1985
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Publisher
Oxford University Press
Copyright
© The British Council
ISSN
0007-1420
eISSN
1471-8391
DOI
10.1093/oxfordjournals.bmb.a072075
Publisher site
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Abstract

Of the viruses which commonly cause superficial eye disease, only herpes simplex and varicella zoster appear amenable to specific treatment at present. Superficial herpetic corneal ulcers respond well to a number of nucleoside and nucleotide derivatives applied tropically, and this is an excellent clinical model in which to test new agents in controlled trials. In such studies, combinations of alpha-interferons with acyclovir or trifluorothymidine have been shown to be more effective than either alone. No strategy has been found to affect recurrences of herpes simplex keratitis. Furthermore, deep stromol disease, uveitis and infections following corneal transplants are more difficult to treat because persistent inflammation does not necessarily reflect persistent viral replication, and may be aggravated by drug toxicity. Controlled trials in herpes zoster ophthalmicus have recently shown that there is a definite advantage in using antiviral agents over steroids.

Journal

British Medical Bulletin – Oxford University Press

Published: Jan 1, 1985

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