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Temperature Effects on Nerve Activity in DDT-Treated American Cockroaches

Temperature Effects on Nerve Activity in DDT-Treated American Cockroaches Abstract As American cockroaches, Periplaneta americana (L.), pass through the successive stages of DDT poisoning when temperature is lowered, a difference is observed in the patterns of activity in sensory nerves and in the central nervous system (CNS). In sensory nerves a direct relationship is obtained between changing temperature and frequency of appearance of DDT-induced trains. In the CNS a negative temperature coefficient is observed for the change in frequency of appearance of DDT-induced trains through the intoxicated stage of poisoning. As the cockroach reaches the prostrate stage of poisoning, the frequency of appearance of DDT-trains is reduced. This observation of contrasting patterns of activity between sensory nerves and the CNS suggests that synaptic transmission is impaired as the stage of DDT poisoning progresses. Data obtained from studies of the 6th abdominal gang-lion and thoracic ganglia confirm the hypothesis of synaptic impairment. The 6th abdominal ganglion becomes increasingly unstable as poisoning progresses. In the thoracic ganglia, increasing instability is observed through early prostration, and a complete block is observed in the later stages. The block which is observed in the late stages is reversible upon a rise in temperature and correlates well with a reversal of symptoms from late to early prostration during recovery. The very dose correlation between stage of poisoning and degree of synaptic impairment in the thoracic ganglia suggests a dose relationship between these 2 events. The magnitude of the effect of low temperature on synaptic conduction strongly suggests that the negative temperature coefficient of DDT action is the direct result of upset synaptic transmission. This content is only available as a PDF. Author notes 1 This investigation was supported in part by a P.H.S. research grant CC-00039, from the National Communicable Disease Center, U.S. Public Health Service. Atlanta, Georgia. Part of a thesis submitted by the senior author in partial fulfillment of the requirements of the Ph.D. degree in Entomology, University of Illinois, Urbana. © 1967 Entomological Society of America http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Economic Entomology Oxford University Press

Temperature Effects on Nerve Activity in DDT-Treated American Cockroaches

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Publisher
Oxford University Press
Copyright
Copyright © 2021 Entomological Society of America
ISSN
0022-0493
eISSN
1938-291X
DOI
10.1093/jee/60.5.1358
Publisher site
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Abstract

Abstract As American cockroaches, Periplaneta americana (L.), pass through the successive stages of DDT poisoning when temperature is lowered, a difference is observed in the patterns of activity in sensory nerves and in the central nervous system (CNS). In sensory nerves a direct relationship is obtained between changing temperature and frequency of appearance of DDT-induced trains. In the CNS a negative temperature coefficient is observed for the change in frequency of appearance of DDT-induced trains through the intoxicated stage of poisoning. As the cockroach reaches the prostrate stage of poisoning, the frequency of appearance of DDT-trains is reduced. This observation of contrasting patterns of activity between sensory nerves and the CNS suggests that synaptic transmission is impaired as the stage of DDT poisoning progresses. Data obtained from studies of the 6th abdominal gang-lion and thoracic ganglia confirm the hypothesis of synaptic impairment. The 6th abdominal ganglion becomes increasingly unstable as poisoning progresses. In the thoracic ganglia, increasing instability is observed through early prostration, and a complete block is observed in the later stages. The block which is observed in the late stages is reversible upon a rise in temperature and correlates well with a reversal of symptoms from late to early prostration during recovery. The very dose correlation between stage of poisoning and degree of synaptic impairment in the thoracic ganglia suggests a dose relationship between these 2 events. The magnitude of the effect of low temperature on synaptic conduction strongly suggests that the negative temperature coefficient of DDT action is the direct result of upset synaptic transmission. This content is only available as a PDF. Author notes 1 This investigation was supported in part by a P.H.S. research grant CC-00039, from the National Communicable Disease Center, U.S. Public Health Service. Atlanta, Georgia. Part of a thesis submitted by the senior author in partial fulfillment of the requirements of the Ph.D. degree in Entomology, University of Illinois, Urbana. © 1967 Entomological Society of America

Journal

Journal of Economic Entomology – Oxford University Press

Published: Oct 1, 1967

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