Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 7-Day Trial for You or Your Team.

Learn More →

Is High Homocysteine Level a Risk Factor for Cognitive Decline in Elderly? A Systematic Review, Meta-Analysis, and Meta-Regression

Is High Homocysteine Level a Risk Factor for Cognitive Decline in Elderly? A Systematic... REGULAR RESEARCH ARTICLES Is High Homocysteine Level a Risk Factor for Cognitive Decline in Elderly? A Systematic Review, Meta-Analysis, and Meta-Regression Roger C. M. Ho, D.P.M., M.R.C. Psych., Mike W. L. Cheung, Ph.D., Erin Fu, B. Soc. Sc., Hlaing H. Win, M.B.B. S., Min Htet Zaw, M.B.B.S., Amanda Ng, B.Sc., Anselm Mak, M.Med.Sc., F.R.CP Obective: High homocysteine (Hct) has been causatively linked to Alzheimer disease (AD) and vascular dementia (VaD) in old age, but research methodologies and out- come measures are heterogeneous. It remains unclear whether the findings can be gen- eralized across studies. Methods: Random-effects meta-analyses were conducted on studies examining the relationship between Hct level and risk of developing dementia/ cognitive decline between comparison groups. Meta-regression identified patient- and trial-related factors, which may contribute to heterogeneity. Results: Seventeen rele- vant studies (6,122 participants; 13 cross-sectional and fourprospective studies) were included. Compared with controls, Hct was significantly elevated in AD (pooled stan- dardized mean difference [SMD]: 0.59; 95% confidence interval [CI]: 0.38–0.80; sig- nificant heterogeneity: τ = 0.105) and VaD (pooled SMD: 1.30; 95% CI: 0.75–1.84; significant heterogeneity: τ = 0.378). Meta-regression identified mean age as sig- nificant moderator for AD versus controls and mean age and mean http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png American Journal of Geriatric Psychiatry Wolters Kluwer Health

Is High Homocysteine Level a Risk Factor for Cognitive Decline in Elderly? A Systematic Review, Meta-Analysis, and Meta-Regression

Mak, Anselm
American Journal of Geriatric Psychiatry , Volume 19 (7) – Jul 1, 2011
Download PDF
11 pages

Loading next page...
 
/lp/wolters-kluwer-health/is-high-homocysteine-level-a-risk-factor-for-cognitive-decline-in-8kKvlX0EUd

References

References for this paper are not available at this time. We will be adding them shortly, thank you for your patience.

Copyright
© 2011 American Association for Geriatric Psychiatry
ISSN
1064-7481
DOI
10.1097/JGP.0b013e3181f17eed
pmid
21705865
Publisher site
See Article on Publisher Site

Abstract

REGULAR RESEARCH ARTICLES Is High Homocysteine Level a Risk Factor for Cognitive Decline in Elderly? A Systematic Review, Meta-Analysis, and Meta-Regression Roger C. M. Ho, D.P.M., M.R.C. Psych., Mike W. L. Cheung, Ph.D., Erin Fu, B. Soc. Sc., Hlaing H. Win, M.B.B. S., Min Htet Zaw, M.B.B.S., Amanda Ng, B.Sc., Anselm Mak, M.Med.Sc., F.R.CP Obective: High homocysteine (Hct) has been causatively linked to Alzheimer disease (AD) and vascular dementia (VaD) in old age, but research methodologies and out- come measures are heterogeneous. It remains unclear whether the findings can be gen- eralized across studies. Methods: Random-effects meta-analyses were conducted on studies examining the relationship between Hct level and risk of developing dementia/ cognitive decline between comparison groups. Meta-regression identified patient- and trial-related factors, which may contribute to heterogeneity. Results: Seventeen rele- vant studies (6,122 participants; 13 cross-sectional and fourprospective studies) were included. Compared with controls, Hct was significantly elevated in AD (pooled stan- dardized mean difference [SMD]: 0.59; 95% confidence interval [CI]: 0.38–0.80; sig- nificant heterogeneity: τ = 0.105) and VaD (pooled SMD: 1.30; 95% CI: 0.75–1.84; significant heterogeneity: τ = 0.378). Meta-regression identified mean age as sig- nificant moderator for AD versus controls and mean age and mean

Journal

American Journal of Geriatric Psychiatry – Wolters Kluwer Health

Published: Jul 1, 2011

References

  • Alzheimer's Disease International: Global prevalence of dementia: a Delphi consensus study
    Ferri
  • Homocysteine and cognition—a historical perspective
    McCaddon
  • Homocysteine and cognitive function in elderly people
    Garcia
  • Dietary patterns and risk of dementia: the Three-City Cohort Study
    Barberger-Gateau
  • Nutritional factors, cognitive decline, and dementia
    Del Parigi
  • Progression of mild cognitive impairment to dementia in clinic- versus community-based cohorts
    Farias
  • Invited commentary
    Berlin
  • Cholesterol as a risk factor for dementia and cognitive decline: a systematic review of prospective studies with meta-analysis
    Anstey
  • Meta-analysis of observational studies in epidemiology: a proposal for reporting. Meta- Analysis of Observational Studies in Epidemiology (MOOSE) Group
    Stroup