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New Paradigm for Studying Genetic Contributions to Irritable Bowel Syndrome

New Paradigm for Studying Genetic Contributions to Irritable Bowel Syndrome Dig Dis Sci (2012) 57:2484–2486 DOI 10.1007/s10620-012-2370-6 EDITORIAL New Paradigm for Studying Genetic Contributions to Irritable Bowel Syndrome Miranda A. L. van Tilburg William E. Whitehead Published online: 29 August 2012 Springer Science+Business Media, LLC 2012 Irritable Bowel Syndrome (IBS) is common disabling because it demonstrates that taking these interactions into condition that is associated with an estimated $8 billion per account can unmask genetic contributions to IBS etiology year in direct healthcare costs [1]. In the past few decades where simple genetic association studies have failed to multiple studies have been published on the etiology of show an effect. This is the second study to show that a IBS, and several pathophysiological factors have been genetic polymorphism interacts with exposure to infectious found to be significantly associated with IBS diagnosis, gastroenteritis to contribute to the expression of post- such as motility disturbances, visceral hypersensitivity, infectious IBS; the first was the study by Villani et al. [7] psychological distress, and immune dysregulation. How- which found that polymorphisms in Toll-like receptor 9, ever, none of these factors is sufficient by itself to explain interleukin (IL)-6, and CDH1 were associated with an the development of IBS. Therefore, it is widely believed http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Digestive Diseases and Sciences Springer Journals

New Paradigm for Studying Genetic Contributions to Irritable Bowel Syndrome

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References (42)

Publisher
Springer Journals
Copyright
Copyright © 2012 by Springer Science+Business Media, LLC
Subject
Medicine & Public Health; Gastroenterology; Hepatology; Oncology; Transplant Surgery; Biochemistry, general
ISSN
0163-2116
eISSN
1573-2568
DOI
10.1007/s10620-012-2370-6
pmid
22926498
Publisher site
See Article on Publisher Site

Abstract

Dig Dis Sci (2012) 57:2484–2486 DOI 10.1007/s10620-012-2370-6 EDITORIAL New Paradigm for Studying Genetic Contributions to Irritable Bowel Syndrome Miranda A. L. van Tilburg William E. Whitehead Published online: 29 August 2012 Springer Science+Business Media, LLC 2012 Irritable Bowel Syndrome (IBS) is common disabling because it demonstrates that taking these interactions into condition that is associated with an estimated $8 billion per account can unmask genetic contributions to IBS etiology year in direct healthcare costs [1]. In the past few decades where simple genetic association studies have failed to multiple studies have been published on the etiology of show an effect. This is the second study to show that a IBS, and several pathophysiological factors have been genetic polymorphism interacts with exposure to infectious found to be significantly associated with IBS diagnosis, gastroenteritis to contribute to the expression of post- such as motility disturbances, visceral hypersensitivity, infectious IBS; the first was the study by Villani et al. [7] psychological distress, and immune dysregulation. How- which found that polymorphisms in Toll-like receptor 9, ever, none of these factors is sufficient by itself to explain interleukin (IL)-6, and CDH1 were associated with an the development of IBS. Therefore, it is widely believed

Journal

Digestive Diseases and Sciences – Springer Journals

Published: Aug 29, 2012

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