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INVITE D COM M ENTARY The Bipolar Spectrum—The Shaping of a New Paradigm in Psychiatry Hagop S. Akiskal, MD Address scarcity of the literature on BP-II is an indication that most International Mood Center, University of California at San Diego, VA bipolar patients with “atypical” presentation are being Psychiatry Service (116-A), 3350 La Jolla Village Drive, San Diego, CA missed in research and, possibly, routine clinical practice 92161, USA. [2,3,8–11]. E-mail: [email protected] In a recent French collaborative study [10], the authors Current Psychiatry Reports 2002, 4:1–3 found that if one were to go by documented past episodes of Current Science Inc. ISSN 1523-3782 hypomania in the records of patients presenting with MDD, Copyright © 2002 by Current Science Inc. only 22% of a cohort of 250 patients could be diagnosed as During the second half of the 20th century, Kraepelin’s BP-II. Re-interview (by specially trained psychiatrists) a broad concept of manic-depressive psychosis was month later, which included observations made by the dethroned in favor of a unipolar-bipolar distinction. None- psychiatrist and family members or significant others, nearly theless, there exist many pseudo-unipolar patients in the doubled the rate of BP-II diagnoses (40%). This sample from interphase of unipolarity and
Current Psychiatry Reports – Springer Journals
Published: May 24, 2002
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