Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 7-Day Trial for You or Your Team.

Learn More →

Stage-specific antigens on the surface membrane of sporozoites of malaria parasites

Stage-specific antigens on the surface membrane of sporozoites of malaria parasites EFFECTIVE immunisation against malaria has been achieved in hosts ranging from birds to man by repeated inoculation of irradiated sporozoites derived from the mosquito vector1–4. In all host–parasite systems so far investigated both the protection against challenge1–3 and the concomitant antibody response2,5,6 are strictly stage-specific, that is, directed exclusively against the sporozoites. The question of whether antisporozoite immunity might also develop in natural conditions in individuals in endemic malaria areas has not been investigated, except for a preliminary study which gave negative results7. Monitoring for antisporozoite antibodies requires a serological test which must differentiate between antibodies directed at sporozoite versus blood stage-specific antigens and must also be highly sensitive (capable of detecting the low level of immunity which might occur in response to the small numbers of sporozoites introduced into the host by the mosquito bite). We report here the development of such a serological test in rodent and simian malaria systems, and the initial results of its application to the sera of a few individuals exposed to Plasmodium falciparum malaria. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Nature Springer Journals

Stage-specific antigens on the surface membrane of sporozoites of malaria parasites

NARDIN, ELIZABETH HIGGINS; NUSSENZWEIG, RUTH S.
Nature , Volume 274 (5666) – Jul 6, 1978
Download PDF
3 pages

Loading next page...
 
/lp/springer-journals/stage-specific-antigens-on-the-surface-membrane-of-sporozoites-of-7ueDeVcRKd

References (11)

Publisher
Springer Journals
Copyright
Copyright © 1978 by Nature Publishing Group
Subject
Science, Humanities and Social Sciences, multidisciplinary; Science, Humanities and Social Sciences, multidisciplinary; Science, multidisciplinary
ISSN
0028-0836
eISSN
1476-4687
DOI
10.1038/274055a0
Publisher site
See Article on Publisher Site

Abstract

EFFECTIVE immunisation against malaria has been achieved in hosts ranging from birds to man by repeated inoculation of irradiated sporozoites derived from the mosquito vector1–4. In all host–parasite systems so far investigated both the protection against challenge1–3 and the concomitant antibody response2,5,6 are strictly stage-specific, that is, directed exclusively against the sporozoites. The question of whether antisporozoite immunity might also develop in natural conditions in individuals in endemic malaria areas has not been investigated, except for a preliminary study which gave negative results7. Monitoring for antisporozoite antibodies requires a serological test which must differentiate between antibodies directed at sporozoite versus blood stage-specific antigens and must also be highly sensitive (capable of detecting the low level of immunity which might occur in response to the small numbers of sporozoites introduced into the host by the mosquito bite). We report here the development of such a serological test in rodent and simian malaria systems, and the initial results of its application to the sera of a few individuals exposed to Plasmodium falciparum malaria.

Journal

Nature – Springer Journals

Published: Jul 6, 1978

There are no references for this article.