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Relative reward preference in primate orbitofrontal cortex

Relative reward preference in primate orbitofrontal cortex The orbital part of prefrontal cortex appears to be crucially involved in the motivational control of goal-directed behaviour 1,2 . Patients with lesions of orbitofrontal cortex show impairments in making decisions about the expected outcome of actions 3 . Monkeys with orbitofrontal lesions respond abnormally to changes in reward expectations 4,5 and show altered reward preferences 6 . As rewards constitute basic goals of behaviour 7 , we investigated here how neurons in the orbitofrontal cortex of monkeys process information about liquid and food rewards in a typical frontal task, spatial delayed responding 8 . The activity of orbitofrontal neurons increases in response to reward-predicting signals, during the expectation of rewards, and after the receipt of rewards. Neurons discriminate between different rewards, mainly irrespective of the spatial and visual features of reward-predicting stimuli and behavioural reactions. Most reward discriminations reflect the animals' relative preference among the available rewards, as expressed by their choice behaviour, rather than physical reward properties. Thus, neurons in the orbitofrontal cortex appear to process the motivational value of rewarding outcomes of voluntary action. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Nature Springer Journals

Relative reward preference in primate orbitofrontal cortex

Tremblay, Léon; Schultz, Wolfram
Nature , Volume 398 (6729) – Apr 22, 1999
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References (31)

Publisher
Springer Journals
Copyright
Copyright © 1999 by Macmillan Magazines Ltd.
Subject
Science, Humanities and Social Sciences, multidisciplinary; Science, Humanities and Social Sciences, multidisciplinary; Science, multidisciplinary
ISSN
0028-0836
eISSN
1476-4687
DOI
10.1038/19525
Publisher site
See Article on Publisher Site

Abstract

The orbital part of prefrontal cortex appears to be crucially involved in the motivational control of goal-directed behaviour 1,2 . Patients with lesions of orbitofrontal cortex show impairments in making decisions about the expected outcome of actions 3 . Monkeys with orbitofrontal lesions respond abnormally to changes in reward expectations 4,5 and show altered reward preferences 6 . As rewards constitute basic goals of behaviour 7 , we investigated here how neurons in the orbitofrontal cortex of monkeys process information about liquid and food rewards in a typical frontal task, spatial delayed responding 8 . The activity of orbitofrontal neurons increases in response to reward-predicting signals, during the expectation of rewards, and after the receipt of rewards. Neurons discriminate between different rewards, mainly irrespective of the spatial and visual features of reward-predicting stimuli and behavioural reactions. Most reward discriminations reflect the animals' relative preference among the available rewards, as expressed by their choice behaviour, rather than physical reward properties. Thus, neurons in the orbitofrontal cortex appear to process the motivational value of rewarding outcomes of voluntary action.

Journal

Nature – Springer Journals

Published: Apr 22, 1999

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