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- Publisher
- Springer Journals
- Copyright
- Copyright © 2013 by Nature Publishing Group, a division of Macmillan Publishers Limited. All Rights Reserved.
- Subject
- Medicine & Public Health; Medicine/Public Health, general; Nephrology
- ISSN
- 1759-5061
- eISSN
- 1759-507X
- DOI
- 10.1038/nrneph.2013.110
- Publisher site
- See Article on Publisher Site
Abstract
Over the past 20 years, it has become clear that aldosterone exerts direct effects on the vasculature, heart and kidney beyond its effects on electrolyte handling in the distal tubule. In addition, mineralocorticoid-receptor activation has been shown to contribute to cardiovascular fibrosis and remodelling as well as to renal disease. This Review describes in detail the proinflammatory and profibrotic effects of aldosterone and mineralocorticoid-receptor activation in the heart, vasculature and kidney.
Journal
Nature Reviews Nephrology – Springer Journals
Published: Jun 18, 2013