Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 7-Day Trial for You or Your Team.

Learn More →

Long‐Term Results of the Viable Cryopreserved Allograft Aortic Valve: Continuing Evidence for Superior Valve Durability

Long‐Term Results of the Viable Cryopreserved Allograft Aortic Valve: Continuing Evidence for... From December 1969 to May 1975, 124 patients underwent aortic valve replacement with an allograft aortic valve sterilized by incubation in a low dose antibiotic solution and stored by refrigeration at 4°C (4°C stored valve group). From June 1975 to December 1987, 231 patients received an allograft aortic valve, sterilized by the same low dose antibiotic solution, but stored by cryopreservation in liquid nitrogen at — 196°C (cryopreserved valve group). The 4°C stored valves were essentially nonviable, whereas the cryopreserved valves were viable at implantation. Of the 355 aortic valve replacements, associated procedures were performed in 127 patients. The 30‐day mortality was 8.9% (confidence limits [C.L.] 6.2%...12.3%) (4°C stored) and 4.8% (C.L. 3.3%...6.7%) (cryopreserved). Actuarial survival was similar in both groups, being 71% and 67% at 10 years in the 4°C stored and cryopreserved valve groups, respectively (P = .18). The probability of a thromboembolic event was low, but appeared higher in the 4°C stored valve group (actuarial freedom at 10 years, 90%) than the cryopreserved valve group (actuarial freedom at 10 years, 98%) (P =.01) probably related to associated mitral valve surgery. The actuarial freedom from allograft valve endocarditis at 10 years was 94% and 95% for the 4°C stored and cryopreserved valve groups, respectively (P = .23). http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Cardiac Surgery Wiley

Long‐Term Results of the Viable Cryopreserved Allograft Aortic Valve: Continuing Evidence for Superior Valve Durability

Download PDF
8 pages

Loading next page...
 
/lp/wiley/long-term-results-of-the-viable-cryopreserved-allograft-aortic-valve-76xsuPK4jZ

References (18)

Publisher
Wiley
Copyright
© Wiley Periodicals, Inc.
ISSN
0886-0440
eISSN
1540-8191
DOI
10.1111/jocs.1988.3.3s.289
Publisher site
See Article on Publisher Site

Abstract

From December 1969 to May 1975, 124 patients underwent aortic valve replacement with an allograft aortic valve sterilized by incubation in a low dose antibiotic solution and stored by refrigeration at 4°C (4°C stored valve group). From June 1975 to December 1987, 231 patients received an allograft aortic valve, sterilized by the same low dose antibiotic solution, but stored by cryopreservation in liquid nitrogen at — 196°C (cryopreserved valve group). The 4°C stored valves were essentially nonviable, whereas the cryopreserved valves were viable at implantation. Of the 355 aortic valve replacements, associated procedures were performed in 127 patients. The 30‐day mortality was 8.9% (confidence limits [C.L.] 6.2%...12.3%) (4°C stored) and 4.8% (C.L. 3.3%...6.7%) (cryopreserved). Actuarial survival was similar in both groups, being 71% and 67% at 10 years in the 4°C stored and cryopreserved valve groups, respectively (P = .18). The probability of a thromboembolic event was low, but appeared higher in the 4°C stored valve group (actuarial freedom at 10 years, 90%) than the cryopreserved valve group (actuarial freedom at 10 years, 98%) (P =.01) probably related to associated mitral valve surgery. The actuarial freedom from allograft valve endocarditis at 10 years was 94% and 95% for the 4°C stored and cryopreserved valve groups, respectively (P = .23).

Journal

Journal of Cardiac Surgery – Wiley

Published: Sep 1, 1988

There are no references for this article.