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References (122)
-
F. Awouters, A. Megens, M. Verlinden, J. Schuurkes, C. Niemegeers, P. Janssen (2005)
LoperamideDigestive Diseases and Sciences, 38
-
S. Thörn, M. Wattwil, G. Lindberg, J. Säwe (1996)
Systemic and central effects of morphine on gastroduodenal motilityActa Anaesthesiologica Scandinavica, 40
-
H. Mertz, B. Naliboff, J. Munakata, N. Niazi, E. Mayer (1995)
Altered rectal perception is a biological marker of patients with irritable bowel syndrome.Gastroenterology, 109 1
-
Awouters Awouters, Megens Megens, Verlinden Verlinden, Schuurkes Schuurkes, Niemegeers Niemegeers, Janssen Janssen (1993)
Loperamide. Survey of studies on mechanism of its antidiarrheal activityDig Dis Sci, 38
-
H. Yukioka, M. Rosen, K. Evans, K. Leach, M. Hayward, G. Saggu (1987)
Gastric emptying and small bowel transit times in volunteers after intravenous morphine and nalbuphineAnaesthesia, 42
-
J. Abrahm (1999)
Management of Pain and Spinal Cord Compression in Patients with Advanced CancerAnnals of Internal Medicine, 131
-
R. Akehurst, E. Kaltenthaler (2001)
Treatment of irritable bowel syndrome: a review of randomised controlled trialsGut, 48
-
J. Rogé, P. Baumer, H. Berard, Jean-Charles Schwartz, Jeanne-Marie Lecomte (1993)
The enkephalinase inhibitor, acetorphan, in acute diarrhoea. A double-blind, controlled clinical trial versus loperamide.Scandinavian journal of gastroenterology, 28 4
-
Rogers Rogers, Cerda Cerda (1989)
The narcotic bowel syndromeJ Clin Gastroenterol, 11
-
C. Yuan, J. Foss, M. O'Connor, T. Karrison, J. Osiński, M. Roizen, J. Moss (2000)
Effects of enteric‐coated methylnaltrexone in preventing opioid‐induced delay in oral‐cecal transit timeClinical Pharmacology & Therapeutics, 67
-
D. Currow, Marie Coughlan, Belinda Fardell, Neil Cooney (1997)
Use of ondansetron in palliative medicine.Journal of pain and symptom management, 13 5
-
C. Yuan, J. Foss, M. O'Connor, J. Osiński, T. Karrison, J. Moss, M. Roizen (2000)
Methylnaltrexone for reversal of constipation due to chronic methadone use: a randomized controlled trial.JAMA, 283 3
-
Farthing Farthing (1999)
Enkephalinase inhibition: a rational approach to antisecretory therapy for acute diarrhoeaAliment Pharmacol Ther, 13
-
Margarita Puig, O. Pol (1998)
Peripheral effects of opioids in a model of chronic intestinal inflammation in mice.The Journal of pharmacology and experimental therapeutics, 287 3
-
F. Chung, R. Lane, C. Spraggs, B. McQuade, M. Jacka, H. Luttropp, S. Alahuta, S. Rocherieux, M. Roy, P. Duvaldestin, P. Curtis (1999)
Ondansetron is more effective than metoclopramide for the treatment of opioid-induced emesis in post-surgical adult patients. Ondansetron OIE Post-Surgical Study Group.European journal of anaesthesiology, 16 10
-
R. Mittal, E. Frank, R. Lange, R. McCallum (1986)
Effects of morphine and naloxone on esophageal motility and gastric emptying in manDigestive Diseases and Sciences, 31
-
F. Simonin, O. Valverde, C. Smadja, S. Slowe, I. Kitchen, A. Dierich, M. Meur, B. Roques, R. Maldonado, B. Kieffer (1998)
Disruption of the κ‐opioid receptor gene in mice enhances sensitivity to chemical visceral pain, impairs pharmacological actions of the selective κ‐agonist U‐50,488H and attenuates morphine withdrawalThe EMBO Journal, 17
-
M. Feldman, J. Walsh, I. Taylor (1980)
Effect of naloxone and morphine on gastric acid secretion and on serum gastrin and pancreatic polypeptide concentrations in humans.Gastroenterology, 79 2
-
L. Bradford, W. Kirlin, Dianne Bradford (1998)
Polymorphism of CYP2D6 in Black populations: implications for psychopharmacology.The international journal of neuropsychopharmacology, 1 2
-
L. Gowing, M. Farrell, R. Ali, J. White (2002)
α2‐Adrenergic agonists in opioid withdrawalAddiction, 97
-
P. Kaufman, B. Krevsky, L. Malmud, A. Maurer, Marjorie Somers, J. Siegel, R. Fisher (1988)
Role of opiate receptors in the regulation of colonic transit.Gastroenterology, 94 6
-
W. Hopman, G. Rosenbusch, J. Jansen, C. Lamers (1990)
Effect of increasing oral doses of loperamide on gallbladder motility in man.British journal of clinical pharmacology, 29 1
-
T. Pappas, A. Mangel, C. Lawson (1999)
Review article: evaluation of drugs in experimental gut distension modelsAlimentary Pharmacology & Therapeutics, 13
-
Junien Junien, Riviere Riviere (1995)
The hypersensitive gut–peripheral kappa agonists as a new pharmacological approachAliment Pharmacol Ther, 9
-
Mark Ainsworth, Jens Kjeldsen, O. Muckadell (1990)
Morphine inhibits secretion of bicarbonate from the human duodenal mucosa. Possible role of endogenous opioids in the regulation of human duodenal mucosal bicarbonate secretion.Scandinavian journal of gastroenterology, 25 10
-
W. Sun, N. Read, M. Verlinden (1997)
Effects of loperamide oxide on gastrointestinal transit time and anorectal function in patients with chronic diarrhoea and faecal incontinence.Scandinavian journal of gastroenterology, 32 1
-
S. Hosztafi, Z. Fürst (1995)
Endogenous morphine.Pharmacological research, 32 1-2
-
S. Delgado-Aros, H. Chial, Filippo Cremonini, I. Ferber, S. Mckinzie, Duane Burton, Michael Camilleri (2003)
Effects of asimadoline, a κ‐opioid agonist, on satiation and postprandial symptoms in healthAlimentary Pharmacology & Therapeutics, 18
-
(1997)
The effects of opioid rotation (OR), dose ratio (DR) on pain control and cognition in patients (P) with cancer pain -
G. Mikus, B. Trausch, Carsten Rodewald, U. Hofmann, K. Richter, T. Gramatté, M. Eichelbaum (1997)
Effect of codeine on gastrointestinal motility in relation to CYP2D6 phenotypeClinical Pharmacology & Therapeutics, 61
-
D. Philippe, L. Dubuquoy, H. Groux, V. Brun, Myriam Chuoï-Mariot, C. Gaveriaux-Ruff, J. Colombel, B. Kieffer, P. Desreumaux (2003)
Anti-inflammatory properties of the mu opioid receptor support its use in the treatment of colon inflammation.The Journal of clinical investigation, 111 9
-
J. Junien, P. Rivière (1995)
Review article: the hypersensitive gut—peripheral kappa agonists as a new pharmacological approachAlimentary Pharmacology & Therapeutics, 9
-
C. Yuan, J. Foss (2000)
Oral methylnaltrexone for opioid-induced constipation.JAMA, 284 11
-
S. Delgado-Aros, H. Chial, M. Camilleri, L. Szarka, F. Weber, Jutta Jacob, I. Ferber, S. Mckinzie, D. Burton, A. Zinsmeister (2003)
Effects of a kappa-opioid agonist, asimadoline, on satiation and GI motor and sensory functions in humans.American journal of physiology. Gastrointestinal and liver physiology, 284 4
-
H. Ariumi, R. Saito, S. Nago, Misako Hyakusoku, Y. Takano, H. Kamiya (2000)
The role of tachykinin NK-1 receptors in the area postrema of ferrets in emesisNeuroscience Letters, 286
-
J. Ballantyne, J. Mao (2003)
medical progress Opioid Therapy for Chronic Pain -
M. Yee, W. Evans, P. Facey, M. Hayward, M. Rosen (1991)
Gastric emptying and small bowel transit in male volunteers after i.m. ketorolac and morphine.British journal of anaesthesia, 67 4
-
L. Gowing, M. Farrell, R. Ali, J. White (2002)
Alpha2-adrenergic agonists in opioid withdrawal.Addiction, 97 1
-
Benoit Coffin, Didier Bouhassira, Robert Chollet, B. Fraitag, C. Meynard, J. Genève, Marc Lémann, J. Willer, Raymond Jian (1996)
Effect of the kappa agonist fedotozine on perception of gastric distension in healthy humansAlimentary Pharmacology & Therapeutics, 10
-
Gowing Gowing, Farrell Farrell, Ali Ali, White White (2002)
Alpha2‐adrenergic agonists in opioid withdrawal.(comment)Addiction, 97
-
W. Schmidt (2001)
Alvimopan* (ADL 8-2698) is a novel peripheral opioid antagonist.American journal of surgery, 182 5A Suppl
-
M. Camilleri, J. Malagelada, V. Stanghellini, A. Zinsmeister, P. Kao, C. Li (1986)
Dose-related effects of synthetic human beta-endorphin and naloxone on fed gastrointestinal motility.The American journal of physiology, 251 1 Pt 1
-
T. Hirayama, F. Ishii, K. Yago, H. Ogata (2001)
Evaluation of the effective drugs for the prevention of nausea and vomiting induced by morphine used for postoperative pain: a quantitative systematic review.Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan, 121 2
-
F. Narducci, G. Bassotti, M. Granata, M. Gaburri, F. Farroni, R. Palumbo, A. Morelli (1986)
Functional dyspepsia and chronic idiopathic gastric stasis. Role of endogenous opiates.Archives of internal medicine, 146 4
-
J. Foss (2001)
A review of the potential role of methylnaltrexone in opioid bowel dysfunction.American journal of surgery, 182 5A Suppl
-
M. Delvaux, D. Louvel, E. Lagier, B. Scherrer, J. Abitbol, J. Frexinos (1999)
The kappa agonist fedotozine relieves hypersensitivity to colonic distention in patients with irritable bowel syndrome.Gastroenterology, 116 1
-
M. Delvaux, D. Louvel, E. Lagier, B. Scherrer, J. Abitbol, J. Frexinos (1999)
The κ agonist fedotozine relieves hypersensitivity to colonic distention in patients with irritable bowel syndromeGastroenterology, 116
-
Stefano Stefano, Goumon Goumon, Casares Casares (2000)
Endogenous morphineTrends Neurosci, 23
-
Hong Ma, Jun Tang, P. White, R. Wender, Thomas Leverone, Rayond Quon, S. Pearce, Franklin Chiao, Susan Erice (2003)
The Effect of Clonidine on Gastrointestinal Side Effects Associated with Ultra-Rapid Opioid DetoxificationAnesthesia & Analgesia, 96
-
Professor Dapoigny, J. Abitbol, B. Fraitag (1995)
Efficacy of peripheral kappa agonist fedotozine versus placebo in treatment of irritable bowel syndromeDigestive Diseases and Sciences, 40
-
N. Hawkes, J. Rhodes, B. Evans, P. Rhodes, A. Hawthorne, G. Thomas (2002)
Naloxone treatment for irritable bowel syndrome — a randomized controlled trial with an oral formulationAlimentary Pharmacology & Therapeutics, 16
-
O. Pol, J. Palacio, M. Puig (2003)
The expression of delta- and kappa-opioid receptor is enhanced during intestinal inflammation in mice.The Journal of pharmacology and experimental therapeutics, 306 2
-
M. Greenwald, M. Stitzer, K. Haberny, K. Haberny (1997)
Human pharmacology of the opioid neuropeptide dynorphin A(1-13).The Journal of pharmacology and experimental therapeutics, 281 3
-
J. Sandgren, M. McPhee, N. Greenberger (1984)
Narcotic bowel syndrome treated with clonidine. Resolution of abdominal pain and intestinal pseudo-obstruction.Annals of internal medicine, 101 3
-
D. Mrcp, Mrcp MD, Frcp MD, D. Barends (1984)
Role of loperamide and placebo in management of irritable bowel syndrome (IBS)Digestive Diseases and Sciences, 29
-
J. Cézard, J. Duhamel, M. Meyer, I. Pharaon, M. Bellaiche, C. Maurage, J. Giniès, Jean Vaillant, J. Girardet, T. Lamireau, A. Poujol, A. Morali, J. Sarles, J. Olives, C. Whately‐Smith, J. Lecomte, Sylvie Audrain (2001)
Efficacy and tolerability of racecadotril in acute diarrhea in children.Gastroenterology, 120 4
-
Sussman Sussman, Shurman Shurman, Creed Creed (1999)
Intravenous ondansetron for the control of opioid‐induced nausea and vomitingClin Ther, 21
-
O. Pol, J. Palacio, M. Puig (2003)
The Expression of δ- and κ-Opioid Receptor Is Enhanced during Intestinal Inflammation in MiceJournal of Pharmacology and Experimental Therapeutics, 306
-
C. Yuan, J. Foss, M. O'Connor, A. Toledano, M. Roizen, J. Moss (1996)
Methylnaltrexone prevents morphine‐induced delay in oral‐cecal transit time without affecting analgesia: A double‐blind randomized placebo‐controlled trialClinical Pharmacology & Therapeutics, 59
-
I. Antonijevic, S. Mousa, M. Schäfer, Christoph Stein (1995)
Perineurial defect and peripheral opioid analgesia in inflammation, 15
-
Joerns Fickel, Didier Bagnol, Stanley Watson, H. Akil (1997)
Opioid receptor expression in the rat gastrointestinal tract: a quantitative study with comparison to the brain.Brain research. Molecular brain research, 46 1-2
-
R. Penagini, B. Bartesaghi, P. Zannini, G. Negri, P. Bianchi (1993)
Lower oesophageal sphincter hypersensitivity to opioid receptor stimulation in patients with idiopathic achalasia.Gut, 34
-
C. Stein (1995)
The control of pain in peripheral tissue by opioids.The New England journal of medicine, 332 25
-
A. Thune, R. Baker, G. Saccone, H. Owen, J. Toouli (1990)
Differing effects of pethidine and morphine on human sphincter of Oddi motilityBritish Journal of Surgery, 77
-
(1971)
Analgesic drugs.Journal of the American Veterinary Medical Association, 158 6
-
D. Murphy, J. Sutton, L. Prescott, M. Murphy (1997)
Opioid‐induced Delay in Gastric Emptying: A Peripheral Mechanism in HumansAnesthesiology, 87
-
C. Yuan, J. Foss, M. O'Connor, J. Osiński, M. Roizen, J. Moss (1999)
Effects of intravenous methylnaltrexone on opioid-induced gut motility and transit time changes in subjects receiving chronic methadone therapy: a pilot studyPAIN®, 83
-
C. Wilder-Smith, L. Hill, J. Wilkins, Lynnette Denny (1999)
Effects of morphine and tramadol on somatic and visceral sensory function and gastrointestinal motility after abdominal surgery.Anesthesiology, 91 3
-
Abrahm Abrahm (1999)
Management of pain and spinal cord compression in patients with advanced cancer. ACP‐ASIM End‐of‐life Care Consensus Panel. American College of Physicians‐American Society of Internal MedicineAnn Intern Med, 131
-
P. Williams, M. Smith (1999)
An assessment of prochlorperazine buccal for the prevention of nausea and vomiting during intravenous patient-controlled analgesia with morphine following abdominal hysterectomy.European journal of anaesthesiology, 16 9
-
J. Turvill, M. Farthing (1997)
Enkephalins and enkephalinase inhibitors in intestinal fluid and electrolyte transportEuropean Journal of Gastroenterology & Hepatology, 9
-
G. Sussman, J. Shurman, M. Creed, L. Larsen, T. Ferrer-Brechner, D. Noll, J. Allegra, R. Montgomery, D. Schreck, E. Grafstein, G. Ramalanjaona, V. Patel, J. Ducharme, P. Ortenwall, E. Foster, M. Ames (1999)
Intravenous ondansetron for the control of opioid-induced nausea and vomiting. International S3AA3013 Study Group.Clinical therapeutics, 21 7
-
B. Miedema, Joel Johnson (2003)
Methods for decreasing postoperative gut dysmotility.The Lancet. Oncology, 4 6
-
Ivan Lichter (1996)
Nausea and vomiting in patients with cancer.Hematology/oncology clinics of North America, 10 1
-
Z. Vieira, E. Zsigmond, B. Duarate, S. Renigers, K. Hirota (1994)
Evaluation of fentanyl and sufentanil on the diameter of the common bile duct by ultrasonography in man: a double blind, placebo controlled study.International journal of clinical pharmacology and therapeutics, 32 6
-
Penagini, B. Bartesaghi, G. Negri, P. Bianchi (1994)
Effect of loperamide on lower oesophageal sphincter pressure in idiopathic achalasia.Scandinavian journal of gastroenterology, 29 12
-
T. Meuser, C. Pietruck, L. Radbruch, P. Stute, K. Lehmann, S. Grond (2001)
Symptoms during cancer pain treatment following WHO-guidelines: a longitudinal follow-up study of symptom prevalence, severity and etiologyPain, 93
-
Roberto Penagini, Paolo Bianchi (1997)
Effect of morphine on gastroesophageal reflux and transient lower esophageal sphincter relaxation.Gastroenterology, 113 2
-
M. Baines (1988)
Nausea and vomiting in the patient with advanced cancer.Journal of pain and symptom management, 3 2
-
D. Costello, H. Borison (1977)
Naloxone antagonizes narcotic self blockade of emesis in the cat.The Journal of pharmacology and experimental therapeutics, 203 1
-
P. Baumer, E. Dorval, J. Bertrand, J. Vetel, J. Schwartz, J. Lecomte (1992)
Effects of acetorphan, an enkephalinase inhibitor, on experimental and acute diarrhoea.Gut, 33
-
J. Ballantyne, J. Mao (2003)
Opioid therapy for chronic pain.The New England journal of medicine, 349 20
-
P. Radnay, D. Duncalf, M. Novakovic, M. Lesser (1984)
Common Bile Duct Pressure Changes after Fentanyl, Morphine, Meperidine, Butorphanol, and NaloxoneAnesthesia & Analgesia, 63
-
T. Borody, E. Quigley, Sidney Phillips, M. Wienbeck, R. Tucker, A. Haddad, A. Zinsmeister (1985)
Effects of morphine and atropine on motility and transit in the human ileum.Gastroenterology, 89 3
-
T. Ness (1999)
Kappa opioid receptor agonists differentially inhibit two classes of rat spinal neurons excited by colorectal distention.Gastroenterology, 117 2
-
M. Makman (1994)
Morphine receptors in immunocytes and neurons.Advances in neuroimmunology, 4 2
-
C. Lacheze, A. Coelho, J. Fioramonti, L. Buéno (1998)
Influence of Trimebutine on Inflammation‐ and Stress‐induced Hyperalgesia to Rectal Distension in RatsJournal of Pharmacy and Pharmacology, 50
-
L. Jivegård, E. Thornell, S. Björck, J. Svanvik (1985)
The effects of morphine and enkephaline on gallbladder function in experimental cholecystitis. Inhibition of inflammatory gallbladder secretion.Scandinavian journal of gastroenterology, 20 9
-
Arnold Wald (2005)
Fecal incontinenceCurrent Treatment Options in Gastroenterology, 8
-
Frauke Musial, P. Enck, K. Kalveram, Joachim Erckenbrecht (1992)
The effect of loperamide on anorectal function in normal healthy men.Journal of clinical gastroenterology, 15 4
-
Roberto Penagini, Alessandra Picone, Paolo Bianchi (1996)
Effect of morphine and naloxone on motor response of the human esophagus to swallowing and distension.The American journal of physiology, 271 4 Pt 1
-
J. Moss, C. Yuan (2002)
Selective postoperative inhibition of gastrointestinal opioid receptors.The New England journal of medicine, 346 6
-
P. Thimister, W. Hopman, R Roermund, H. Willems, G. Rosenbusch, R. Woestenborghs, J. Jansen (1997)
Inhibition of pancreaticobiliary secretion by loperamide in humansHepatology, 26
-
W. Meissner, U. Schmidt, M. Hartmann, R. Kath, K. Reinhart (2000)
Oral naloxone reverses opioid-associated constipationPain, 84
-
L. Cheskin, L. Cheskin, Tawfik Chamia, Tawfik Chamia, Rolley Johnson, J. Jaffe (1995)
Assessment of nalmefene glucuronide as a selective gut opioid antagonist.Drug and alcohol dependence, 39 2
-
T. Lewis (1999)
Morphine and Gastroduodenal MotilityDigestive Diseases and Sciences, 44
-
Chung Chung, Lane Lane, Spraggs Spraggs (1999)
Ondansetron is more effective than metoclopramide for the treatment of opioid‐induced emesis in post‐surgical adult patientsEur J Anaesthesiol, 16
-
Spencer Liu, P. Hodgson, R. Carpenter, J. Fricke (2001)
ADL 8‐2698, a trans‐3,4‐dimethyl‐4‐ (3‐hydroxyphenyl) piperidine, prevents gastrointestinal effects of intravenous morphine without affecting analgesiaClinical Pharmacology & Therapeutics, 69
-
G. Stacher, H. Steinringer, C. Schneider, G. Vacariu-Granser, F. Castiglione, G. Gaupmann, U. Weber, G. Stacher-Janotta (1992)
Effects of the prodrug loperamide oxide, loperamide, and placebo on jejunal motor activityDigestive Diseases and Sciences, 37
-
J. Vetel, H. Berard, N. Fretault, J. Lecomte (1999)
Comparison of racecadotril and loperamide in adults with acute diarrhoeaAlimentary Pharmacology & Therapeutics, 13
-
L. Bergman, L. Djärv (1981)
A comparative study of loperamide and diphenoxylate in the treatment of chronic diarrhoea caused by intestinal resection.Annals of clinical research, 13 6
-
G. Kachel, H. Ruppin, J. Hagel, W. Barina, M. Meinhardt, W. Domschke (1986)
Human intestinal motor activity and transport: effects of a synthetic opiate.Gastroenterology, 90 1
-
K. Dowlatshahi, A. Evander, B. Walther, D. Skinner (1985)
Influence of morphine on the distal oesophagus and the lower oesophageal sphincter--a manometric study.Gut, 26
-
Talley Nj (1993)
Nonulcer dyspepsia: current approaches to diagnosis and management.American family physician, 47 6
-
M. Feldman, Yolanda Cowley (1982)
Effect of an opiate antagonist (naloxone) on the gastric acid secretory response to sham feeding, pentagastrin, and histamine in manDigestive Diseases and Sciences, 27
-
M. Göke, K. Ewe, K. Donner, K. Büschenfelde (1992)
Influence of loperamide and loperamide oxide on the anal sphincterDiseases of the Colon & Rectum, 35
-
Dapoigny Dapoigny, Abitbol Abitbol, Fraitag Fraitag (1995)
Efficacy of peripheral kappa agonist fedotozine versus placebo in treatment of irritable bowel syndrome. A multicenter dose‐response studyDig Dis Sci, 40
-
Goke Goke, Ewe Ewe, Donner Donner (1992)
Meyer zum Buschenfelde K.H. Influence of loperamide and loperamide oxide on the anal sphincter. A manometric studyDis Colon Rectum, 35
-
T. Fagerlund, O. Braaten (2001)
No pain relief from codeine...? An introduction to pharmacogenomics.Acta anaesthesiologica Scandinavica, 45 2
-
M. Feldman, L. Moore, J. Walsh (1985)
Effect of oral nalmefene, an opiate-receptor antagonist, on meal-stimulated gastric acid secretion and serum gastrin concentration in manRegulatory Peptides, 11
-
C. Wilder-Smith, L. Hill, W. Osler, S. O'keefe (1999)
Effect of Tramadol and Morphine on Pain and Gastrointestinal Motor Function in Patients with Chronic PancreatitisDigestive Diseases and Sciences, 44
-
M. Read, N. Read, D. Barber, H. Duthie (1982)
Effects of loperamide on anal sphincter function in patients complaining of chronic diarrhea with fecal incontinence and urgencyDigestive Diseases and Sciences, 27
-
K. Palmer, C. Corbett, C. Holdsworth (1980)
Double-blind cross-over study comparing loperamide, codeine and diphenoxylate in the treatment of chronic diarrhea.Gastroenterology, 79 6
-
D. Bagnol, A. Mansour, H. Akil, S. Watson (1997)
Cellular localization and distribution of the cloned mu and kappa opioid receptors in rat gastrointestinal tractNeuroscience, 81
-
B. Fraitag, M. Homerin, P. Hecketsweiler (1994)
Double-blind dose-response multicenter comparison of fedotozine and placebo in treatment of nonulcer dyspepsiaDigestive Diseases and Sciences, 39
-
M. Farthing (1999)
Introduction. Enkephalinase inhibition: a rational approach to antisecretory therapy for acute diarrhoeaAlimentary Pharmacology & Therapeutics, 13
-
C. Ripamonti, L. Groff, C. Brunelli, D. Polastri, A. Stavrakis, F. Conno (1998)
Switching from morphine to oral methadone in treating cancer pain: what is the equianalgesic dose ratio?Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 16 10
-
O. Pol, I. Ferrer, M. Puig (1994)
Diarrhea associated with intestinal inflammation increases the potency of mu and delta opioids on the inhibition of gastrointestinal transit in mice.The Journal of pharmacology and experimental therapeutics, 270 1
-
G. Pasternak (1993)
Pharmacological mechanisms of opioid analgesics.Clinical neuropharmacology, 16 1
-
W. Kromer (1990)
Endogenous opioids, the enteric nervous system and gut motility.Digestive diseases, 8 6
-
(2003)
Opioid-induced bowel dysfunction: pathophysiology and potential new therapies -
A. Luca, I. Coupar (1996)
Insights into opioid action in the intestinal tract.Pharmacology & therapeutics, 69 2
- Publisher
- Wiley
- Copyright
- Copyright © 2004 Wiley Subscription Services, Inc., A Wiley Company
- ISSN
- 1350-1925
- eISSN
- 1365-2982
- DOI
- 10.1111/j.1365-2982.2004.00513.x
- pmid
- 15305992
- Publisher site
- See Article on Publisher Site
Abstract
Abstract This article reviews the pharmacology and physiology of opiate receptors and the current and potential uses of opioid agonists and antagonists in clinical gastroenterology. μ‐receptors are involved in motor and sensory functions, and their modulation is established for treatment of diarrhea. μ‐antagonists have potential to reverse endogenous (e.g., postoperative ileus) or iatrogenic dysmotility (e.g., opioid bowel dysfunction). Modulation of the function of κ‐receptors may be a novel approach to control visceral pain in functional gut disorders. Results of formal testing of novel opioid modulators are keenly awaited.
Journal
Neurogastroenterology & Motility – Wiley
Published: Aug 1, 2004