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A Study of Heart Disease in One Hundred Eight Hospitalized Patients Dying with Portal Cirrhosis

A Study of Heart Disease in One Hundred Eight Hospitalized Patients Dying with Portal Cirrhosis Abstract The general status of the cardiovascular system in portal cirrhosis has been referred to in many excellent studies. It would appear from these studies that moderate to severe coronary arteriosclerosis is less common in patients with portal cirrhosis up to the age of 55 years than in patients without portal cirrhosis.5 The incidence of hypertension associated with portal cirrhosis has been recorded as less than that in a similar age group without portal cirrhosis,3,5,6 although there is not complete agreement on this point.4 Although not stated implicitly in these studies, it is suggested that serious heart disease may be less common in patients with portal cirrhosis than in the normal population. Materials and Methods In order to assess the incidence and type of heart disease in patients with portal cirrhosis, 108 consecutive patients who died with portal cirrhosis and were autopsied were studied. It should be noted that the patients did not all References 1. Roessle, R., and Roulet, F.: Pathologie und Klinik in Einzeldarstellungen , Berlin, Springer-Verlag, 1932, Vol. 5, p. 144. 2. Smith, H. L.: Relation of Weight of Heart to Weight of Body and of the Weight of Heart to Age , Am. Heart J. 4:79-93, 1928.Crossref 3. Spatt, S. D., and Rosenblatt, P.: The Incidence of Hypertension in Portal Cirrhosis: A Study of 80 Necropsied Cases of Portal Cirrhosis , Ann. Int. Med. 31:479-483, 1949.Crossref 4. Kirshbaum, J. D., and Shure, N.: Alcoholic Cirrhosis of the Liver: A Clinical and Pathologic Study of 356 Fatal Cases Selected from 12,267 Necropsies , J. Lab. & Clin. Med. 28:721, 1943. 5. Hall, E. M.; Olsen, A. Y., and Davis, F. E.: Portal Cirrhosis: Clinical and Pathologic Review of 782 Cases from 16,600 Necropsies , Am. J. Path. 29:993-1027, 1953. 6. Loyke, H. F.: The Relationship of Cirrhosis of the Liver to Hypertension: A Study of 504 Cases of Cirrhosis of the Liver , Am. J. M. Sc. 230:627-632, 1955. 7. Kelty, R. H.; Baggenstoss, A. H., and Butt, H. R.: The Relation of the Regenerated Liver Nodule to the Vascular Bed in Cirrhosis , Gastroenterology 15:285-295, 1950. 8. Popper, H.; Elias, H., and Petty, D. E.: Vascular Pattern of Cirrhotic Liver , Am. J. Clin. Path. 22:717-729, 1952. 9. Bradley, S. E.; Ingelfinger, F. J., and Bradley, G. P.: Hepatic Circulation in Cirrhosis of the Liver , Circulation 5:419-429, 1952. 10. Myers, J. D.: The Hepatic Blood Flow in Laennec's Cirrhosis, with an Estimate of the Relative Contributions from Portal Vein and Hepatic Artery , J. Clin. Invest. 29:836-837, 1950. 11. Follis, R. H.: The Pathology of Nutritional Diseases , Springfield, Ill., Charles C Thomas, Publisher, 1948. 12. Wenckebach, K. F.: Das Beriberi-Herz: Morphologie, Klinik, Pathogenese; Pathologie und Klinik in Einzeldarstellungen , Berlin, Springer-Verlag, 1934, Vol. 6, p. 106. 13. Claypool, J. G.; Delp, M., and Lin, T. K.: Hemodynamic Studies in Patients with Laennec's Cirrhosis , Am. J. M. Sc. 234:49-55, 1957. 14. Kowalski, H. F., and Abelmann, W. H.: The Cardiac Output at Rest in Laennec's Cirrhosis , J. Clin. Invest. 32:1025-1033, 1953. 15. Shorr, E.; Zweifach, B. W.; Furchgott, R. F., and Baez, S.: Hepatorenal Factors in Circulatory Homeostasis: Tissue Origins of the Vasotropic Principles, VEM and VDM, Which Appear During Evolution of Hemorrhagic and Tourniquet Shock , Circulation 3:42-79, 1951. 16. Weiss, S., and Wilkins, R. W.: Nature of Cardiovascular Disturbances in Vitamin Deficiency States , Tr. A. Am. Physicians 51:341-373, 1936. 17. Weiss, S.: Occidental Beriberi with Cardiovascular Manifestations: Its Relation to Thiamin Deficiency , J. A. M. A. 115:832-839, 1940. 18. Huston, J. H. (Instructor in Medicine and Physician in Charge of Cardio-Pulmonary Labora¬ tory, Marquette University School of Medicine): Personal communication to the authors. 19. Gould, S. E., Editor: Pathology of the Heart , Springfield, Ill., Charles C Thomas, Publisher, 1953. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png A.M.A. Archives of Internal Medicine American Medical Association

A Study of Heart Disease in One Hundred Eight Hospitalized Patients Dying with Portal Cirrhosis

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References (19)

Publisher
American Medical Association
Copyright
Copyright © 1958 American Medical Association. All Rights Reserved.
ISSN
0888-2479
DOI
10.1001/archinte.1958.00030010405009
Publisher site
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Abstract

Abstract The general status of the cardiovascular system in portal cirrhosis has been referred to in many excellent studies. It would appear from these studies that moderate to severe coronary arteriosclerosis is less common in patients with portal cirrhosis up to the age of 55 years than in patients without portal cirrhosis.5 The incidence of hypertension associated with portal cirrhosis has been recorded as less than that in a similar age group without portal cirrhosis,3,5,6 although there is not complete agreement on this point.4 Although not stated implicitly in these studies, it is suggested that serious heart disease may be less common in patients with portal cirrhosis than in the normal population. Materials and Methods In order to assess the incidence and type of heart disease in patients with portal cirrhosis, 108 consecutive patients who died with portal cirrhosis and were autopsied were studied. It should be noted that the patients did not all References 1. Roessle, R., and Roulet, F.: Pathologie und Klinik in Einzeldarstellungen , Berlin, Springer-Verlag, 1932, Vol. 5, p. 144. 2. Smith, H. L.: Relation of Weight of Heart to Weight of Body and of the Weight of Heart to Age , Am. Heart J. 4:79-93, 1928.Crossref 3. Spatt, S. D., and Rosenblatt, P.: The Incidence of Hypertension in Portal Cirrhosis: A Study of 80 Necropsied Cases of Portal Cirrhosis , Ann. Int. Med. 31:479-483, 1949.Crossref 4. Kirshbaum, J. D., and Shure, N.: Alcoholic Cirrhosis of the Liver: A Clinical and Pathologic Study of 356 Fatal Cases Selected from 12,267 Necropsies , J. Lab. & Clin. Med. 28:721, 1943. 5. Hall, E. M.; Olsen, A. Y., and Davis, F. E.: Portal Cirrhosis: Clinical and Pathologic Review of 782 Cases from 16,600 Necropsies , Am. J. Path. 29:993-1027, 1953. 6. Loyke, H. F.: The Relationship of Cirrhosis of the Liver to Hypertension: A Study of 504 Cases of Cirrhosis of the Liver , Am. J. M. Sc. 230:627-632, 1955. 7. Kelty, R. H.; Baggenstoss, A. H., and Butt, H. R.: The Relation of the Regenerated Liver Nodule to the Vascular Bed in Cirrhosis , Gastroenterology 15:285-295, 1950. 8. Popper, H.; Elias, H., and Petty, D. E.: Vascular Pattern of Cirrhotic Liver , Am. J. Clin. Path. 22:717-729, 1952. 9. Bradley, S. E.; Ingelfinger, F. J., and Bradley, G. P.: Hepatic Circulation in Cirrhosis of the Liver , Circulation 5:419-429, 1952. 10. Myers, J. D.: The Hepatic Blood Flow in Laennec's Cirrhosis, with an Estimate of the Relative Contributions from Portal Vein and Hepatic Artery , J. Clin. Invest. 29:836-837, 1950. 11. Follis, R. H.: The Pathology of Nutritional Diseases , Springfield, Ill., Charles C Thomas, Publisher, 1948. 12. Wenckebach, K. F.: Das Beriberi-Herz: Morphologie, Klinik, Pathogenese; Pathologie und Klinik in Einzeldarstellungen , Berlin, Springer-Verlag, 1934, Vol. 6, p. 106. 13. Claypool, J. G.; Delp, M., and Lin, T. K.: Hemodynamic Studies in Patients with Laennec's Cirrhosis , Am. J. M. Sc. 234:49-55, 1957. 14. Kowalski, H. F., and Abelmann, W. H.: The Cardiac Output at Rest in Laennec's Cirrhosis , J. Clin. Invest. 32:1025-1033, 1953. 15. Shorr, E.; Zweifach, B. W.; Furchgott, R. F., and Baez, S.: Hepatorenal Factors in Circulatory Homeostasis: Tissue Origins of the Vasotropic Principles, VEM and VDM, Which Appear During Evolution of Hemorrhagic and Tourniquet Shock , Circulation 3:42-79, 1951. 16. Weiss, S., and Wilkins, R. W.: Nature of Cardiovascular Disturbances in Vitamin Deficiency States , Tr. A. Am. Physicians 51:341-373, 1936. 17. Weiss, S.: Occidental Beriberi with Cardiovascular Manifestations: Its Relation to Thiamin Deficiency , J. A. M. A. 115:832-839, 1940. 18. Huston, J. H. (Instructor in Medicine and Physician in Charge of Cardio-Pulmonary Labora¬ tory, Marquette University School of Medicine): Personal communication to the authors. 19. Gould, S. E., Editor: Pathology of the Heart , Springfield, Ill., Charles C Thomas, Publisher, 1953.

Journal

A.M.A. Archives of Internal Medicine – American Medical Association

Published: Sep 1, 1958

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